Oil-in-water compound spironolactone nano emulsion medicine

Abstract

The invention discloses an oil-in-water compound spironolactone nano emulsion medicine. The nano medicine is prepared from the following raw materials in percentage by mass: 1 to 5 percent of spironolactone, 15 to 30 percent of surfactant, 5 to 20 percent of cosurfactant, 5 to 20 percent of oil, 0.5 to 10 percent of hawthorn extract, 0.5 to 1.0 percent of wild ginger extract and the balance of distilled water, and the sum of the mass percentages of the components is 100 percent. After spironolactone is prepared into the nano emulsion preparation, so that the blood brain barrier penetrating capacity is improved obviously, the bioavailability of raw medicines is improved obviously, the half-life period of the medicine is prolonged, and the administration times are reduced; the nano emulsion improves the medicine dissolution and infiltration capacity of spironolactone and the stability of spironolactone; and after the hawthorn water extract and the wild ginger water extract are compounded, the nano emulsion medicine is obvious in synergistic effect, and is full in curative effect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of an antihypertensive drug spironolactone, in particular to an oil-in-water type compound spironolactone nanoemulsion drug. . Background technique [0002] Oil-in-water spironolactone (spironolactone, Antisterone, Aldactine, Aldonar, Verospiron, spirolang) chemical name 17β-hydroxy-3-oxo-7α-(acetylthio)-17α-pregna-4-ene-21-carboxylic acid γ-lactone, the molecular formula is C 24 h 32 o 4 S, molecular weight 416.57, CAS No. 52-01-7. [0003] Existing antihypertensive drugs such as spironolactone tablets are available on the market now, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Spironolactone itself acts slowly, so that the drug effect of spironolactone cannot be utilized quickly....

AI Technical Summary

Problems solved by technology

[0003] Existing antihypertensive drugs such as spironolactone tablets are available on the market now, although they can be absorbed from the gastrointestinal tract after oral administration, the absorption rate is slow and incomplete. In addition, the dissolution rate of the drug in the tablet is slow and the bioavailability is poor. Spironolactone itself acts slowly, so that the drug effect of spironolactone cannot be utilized quickly