Captopril-carrying nano-grade fiber sustained-release system and preparation method thereof

A nanofiber and sustained-release body technology, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, can solve the problem of few reports on captopril sustained-release fibers, etc. The effect of reducing the toxic and side effects of drugs, low equipment cost, and improving the effective utilization rate
CN102727441AInactive Publication Date: 2012-10-17DONGHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DONGHUA UNIV
Publication Date
2012-10-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a captopril-carrying nano-grade fiber sustained-release system and a preparation method thereof. The sustained-release system comprises the components of: a biodegradable high-molecular material and captopril. The drug-loading rate of the system is 8-80wt%, and the diameter of the nano-grade fiber is 80nm-1.20mum. The preparation method comprises the steps that: (1) the biodegradable high-molecular material is dissolved in an organic solvent; the mixture is stirred until the material is completely dissolved; captopril is added and the mixture is stirred; the mixture is subjected to ultrasonic deaeration, such that a spinning liquid is obtained; (2) the spinning liquid is added into an injector, and electrostatic spinning is carried out, such that the captopril-carrying nano-grade fiber sustained-release system is obtained. According to the invention, with the nano-grade sustained-release system composed of the drug-carrying nano-grade fiber, drug release is effectively controlled. The biodegradable high-molecular material can be automatically degraded with human metabolism, such that an effect of sustained-release is achieved. The process is simple, an equipment cost is low, the conditions are easy to control, and drug availability is improved.
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Description

Technical field

[0001] The invention belongs to the field of captopril carriers and their preparation, and particularly relates to a slow-release body containing captopril nanofibers and a preparation method thereof. Background technique

[0002] Hypertension is the most common cardiovascular and cerebrovascular disease. Due to its frequency and impact on the heart, kidneys and other organs, it has become a major public health problem worldwide.

[0003] Angiotensin converting enzyme (ACE) inhibitors have become the first choice for the treatment of hypertension. Captopril (Cpl) is the first angiotensin converting enzyme inhibitor to be used clinically, and is mainly used for the treatment of hypertension, heart failure and other diseases. Its chemical name is 1-[(2S)-3-mercapto-2-methylpropionyl]-Lproline (C9H15NO3S). The antihypertensive mechanism is to inhibit the activity of angiotensin converting enzyme, reduce the level of angiotensin II, Diastolic arterioles and so on. Ho...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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