Costustoot pharmaceutical composition and medicinal application

A technology of composition and medicine, which is applied in the field of medicine, can solve the problems that the anti-tumor medical use of the essential oil of woody fragrance has not been reported, and achieve good anti-tumor activity, significant synergistic effect, and the effect of enhancing physical fitness

Inactive Publication Date: 2012-10-24
SHANGHAI JIAO TONG UNIV
View PDF1 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there have been reports in the literature on the in vitro anti-tumor research on the monomeric compounds of cory

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Costustoot pharmaceutical composition and medicinal application
  • Costustoot pharmaceutical composition and medicinal application
  • Costustoot pharmaceutical composition and medicinal application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The preparation of embodiment 1 pharmaceutical composition, woody volatile oil and pharmaceutical preparation

[0050] One, the preparation of pharmaceutical composition:

[0051] Method 1: Take 100 mg of corylidene and 100 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.

[0052] Method 2: Take 1 g of coylin and 400 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.

[0053] Method 3: Take 300 mg of corylidene and 700 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.

[0054] Method 4: Take 400 mg of corylidene and 1 g of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.

[0055] Two, the preparation of woody volatile oil:

[0056] Method 5:

[0057] Take 50g of dry woody medicinal material, crush it appropriately, put it into a 1000ml beaker, soak it with 10 times the amount of n-hexane for 1 hour, then extract it ultrasonically...

Embodiment 2

[0070] Example 2 Different methods of preparing the volatile oil components and tumor suppressor effect comparison

[0071] 1. Experimental materials:

[0072] 1.1 Experimental cell line: human breast cancer cell MCF-7.

[0073] 1.2 The volatile oil of woody fragrance obtained by different extraction methods:

[0074] Method A: Same as method 5 of Example 1, the obtained volatile oil of Akiras chinensis is marked as volatile oil 1.

[0075] Method B: Same as method 9 of Example 1, the obtained volatile oil of Cinnamomum sinensis is marked as volatile oil 2.

[0076] Method C: Same as method 6 of Example 1, the obtained volatile oil of Akiras chinensis is marked as volatile oil 3.

[0077] 2. Experimental method

[0078] 2.1 Analysis of the constituents of the essential oils obtained by different extraction methods

[0079] Two-dimensional gas chromatography-mass spectrometry and liquid chromatography were used to analyze the contents of corylidene and dehydrocorylides in ...

Embodiment 3

[0093] Example 3 In vitro cell experiments for different cancer cells

[0094] 1. Experimental materials

[0095] 1.1 Experimental cell lines

[0096] Human breast cancer cell MCF-7, human cervical cancer cell Hela, human promyelocytic leukemia cell HL-60, and human chronic myelogenous leukemia cell K562.

[0097] 1.2 Test drugs

[0098] Standard C: Take 150mg of couscous lactone (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), add 5ml of absolute ethanol, ultrasonically dissolve, add 5ml of polyoxyethylene castor oil, mix well, add 40ml of normal saline, and ultrasonically dissolve , vortexed and mixed evenly, packaged, sterilized, and a sterile injection solution was obtained, marked as C.

[0099] Standard D: Take 150mg of dehydrocresinolide (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), add 5ml of absolute ethanol, ultrasonically dissolve, add 5ml of polyoxyethylene castor oil, mix well, add 40ml of normal saline, Sonication, vortex mixing, packaging,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the medicinal field, and concretely discloses a costustoot pharmaceutical composition and a medicinal application. The pharmaceutical composition of the present invention is composed of costunolide and dehydrocostus lactone; and the invention also discloses a costustoot volatile oil and a medicinal preparation, and the application of the costustoot volatile oil and the medicinal preparation by being taken as antitumor drugs. In the pharmaceutical composition, the volatile oil and the medicinal preparation, costunolide and dehydrocostus lactone have substantial synergism, the toxic and side effects are small, the pharmaceutical composition, the volatile oil and the medicinal preparation have good clinic application prospect, the preparation method is simple, the cost is low, and the pharmaceutical composition, the volatile oil and the medicinal preparation are suitable for requirements of industrial production.

Description

technical field [0001] The invention relates to the field of medicine, and specifically discloses a woody essential oil and a pharmaceutical composition thereof, as well as their preparation method and application. Background technique [0002] Volatile oil of traditional Chinese medicine, also known as essential oil, is a general term for volatile oily components immiscible with water in traditional Chinese medicine. Pain, antipyretic, diuretic, stomach invigorating, antibacterial, insecticidal and cardiotonic, etc. [0003] Muxiang is the dry root of Saussurea lappa Decne, a perennial herb of Compositae. It is mainly produced in Yunnan, also known as Yunmuxiang. Traditional medicine and modern pharmacology studies have shown that woody incense has the functions of invigorating the spleen and stomach, regulating qi and relieving depression, analgesia, improving gastric ulcer, promoting gallbladder contraction, anti-inflammation, and improving myocardial infarction and angi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/365A61K36/285A61P35/00
Inventor 阎超彭章晓王彦温元元
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap