Costustoot pharmaceutical composition and medicinal application
A technology of composition and medicine, which is applied in the field of medicine, can solve the problems that the anti-tumor medical use of the essential oil of woody fragrance has not been reported, and achieve good anti-tumor activity, significant synergistic effect, and the effect of enhancing physical fitness
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Embodiment 1
[0049] The preparation of embodiment 1 pharmaceutical composition, woody volatile oil and pharmaceutical preparation
[0050] One, the preparation of pharmaceutical composition:
[0051] Method 1: Take 100 mg of corylidene and 100 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.
[0052] Method 2: Take 1 g of coylin and 400 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.
[0053] Method 3: Take 300 mg of corylidene and 700 mg of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.
[0054] Method 4: Take 400 mg of corylidene and 1 g of dehydrocorylide and mix them uniformly to prepare a pharmaceutical composition.
[0055] Two, the preparation of woody volatile oil:
[0056] Method 5:
[0057] Take 50g of dry woody medicinal material, crush it appropriately, put it into a 1000ml beaker, soak it with 10 times the amount of n-hexane for 1 hour, then extract it ultrasonically...
Embodiment 2
[0070] Example 2 Different methods of preparing the volatile oil components and tumor suppressor effect comparison
[0071] 1. Experimental materials:
[0072] 1.1 Experimental cell line: human breast cancer cell MCF-7.
[0073] 1.2 The volatile oil of woody fragrance obtained by different extraction methods:
[0074] Method A: Same as method 5 of Example 1, the obtained volatile oil of Akiras chinensis is marked as volatile oil 1.
[0075] Method B: Same as method 9 of Example 1, the obtained volatile oil of Cinnamomum sinensis is marked as volatile oil 2.
[0076] Method C: Same as method 6 of Example 1, the obtained volatile oil of Akiras chinensis is marked as volatile oil 3.
[0077] 2. Experimental method
[0078] 2.1 Analysis of the constituents of the essential oils obtained by different extraction methods
[0079] Two-dimensional gas chromatography-mass spectrometry and liquid chromatography were used to analyze the contents of corylidene and dehydrocorylides in ...
Embodiment 3
[0093] Example 3 In vitro cell experiments for different cancer cells
[0094] 1. Experimental materials
[0095] 1.1 Experimental cell lines
[0096] Human breast cancer cell MCF-7, human cervical cancer cell Hela, human promyelocytic leukemia cell HL-60, and human chronic myelogenous leukemia cell K562.
[0097] 1.2 Test drugs
[0098] Standard C: Take 150mg of couscous lactone (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), add 5ml of absolute ethanol, ultrasonically dissolve, add 5ml of polyoxyethylene castor oil, mix well, add 40ml of normal saline, and ultrasonically dissolve , vortexed and mixed evenly, packaged, sterilized, and a sterile injection solution was obtained, marked as C.
[0099] Standard D: Take 150mg of dehydrocresinolide (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), add 5ml of absolute ethanol, ultrasonically dissolve, add 5ml of polyoxyethylene castor oil, mix well, add 40ml of normal saline, Sonication, vortex mixing, packaging,...
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Abstract
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Application Information
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