Method for preparing caffeic acid phenethyl ester

Abstract

The invention provides a method for preparing caffeic acid phenethyl ester. The method comprises steps that 3, 4-dihydroxy benzaldehyde and phenylethyl acetate are subjected to microwave irradiation for 1 to 2 hours under catalysis of an organic base in a protic organic solvent to synthesize the caffeic acid phenethyl ester. According to invention, the method has advantages of simple technology, one-step synthesis, cheap and easily-available raw materials, non-toxic sodium alkoxide catalyst and low synthesis cost, the reaction can be carried out at room temperature, a yield is more than 85%, and the method is suitable for industrial production.

Description

technical field

[0001] The invention belongs to the field of drug synthesis, in particular to a preparation method of phenethyl caffeate. Background technique

[0002] Propolis has a wide range of plant sources, and its chemical composition is extremely complex. So far, more than 20 types and more than 300 chemical components have been identified from propolis, mainly including flavonoids, phenolic acids, terpene acids, steroids, and amino acids. substances, etc. Among the many functional components of propolis, caffeic acid phenylethyl ester (CPAE) has been identified as one of the main active components in propolis, and many biological activities of propolis are related to CPAE. Phenylethyl caffeate has various pharmacological activities such as anti-oxidation, anti-virus, DNA inhibition, apoptosis induction, anti-bacterial, anti-inflammatory, anti-arteriosclerosis and immunity enhancement, etc. It has broad application prospects in food, medicine and other fields. [00...