Human urate oxidase protein and preparation method and polyethylene glycol composite thereof

A technology of uric acid oxidase protein and polyethylene glycol, applied in the field of protease, can solve the problems of unsuitability for long-term use, allergy, immunogenicity and the like
CN102757945AActive Publication Date: 2012-10-31HANGZHOU JUNFENG BIOENG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGZHOU JUNFENG BIOENG
Publication Date
2012-10-31

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Abstract

The invention discloses a human urate oxidase protein which is formed by SEQ ID NO.3 amino acid sequences. By the human urate oxidase protein, mutation codes in human urate oxidase gene can be reserved, and the human urate oxidase gene subjected to reserve mutation can be introduced into engineering bacteria to realize expression of human urate oxidase gene so as to generate urate oxidase protein with enzyme activity. The polyethylene glycol human urate oxidase protein composite and drug composition have oxygenolysis uric acid activity and can be used for treatment of hyperuricemia and diseases (such as gout) caused by high uric acid.
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Description

field of invention

[0001] The invention relates to a protease with uric acid decomposition activity prepared by genetic engineering technology, more specifically, the invention relates to a novel urate oxidase protein and a preparation method thereof. Background technique

[0002] Uric acid oxidase (urate oxidase, uricase, uricase, E.C.1.7.3.3) is an enzyme in the degradation and metabolism pathway in organisms, which catalyzes the oxidation of uric acid to allantoin with higher solubility, and the solubility of allantoin is higher than that of uric acid About 10 times higher, is the more easily excreted purine metabolite. Uric acid oxidase is found in many species, but it is lacking in higher mammalian primates and humans, so uric acid is the end product of purine metabolism. The solubility of uric acid and its salts in water is very low. Excessive accumulation in the blood will lead to hyperuricemia. If uric acid forms crystals and deposits in soft tissues, joints, organs...

Claims

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