Application of valnemulin hydrochloride

A technology of vornimulin hydrochloride and its application is applied in the field of vornimulin hydrochloride, which can solve the problem of no chicken infectious diseases, and achieve the effects of no drug resistance and obvious therapeutic effect.

Inactive Publication Date: 2012-11-07
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of warnemulin hydrochloride and its

Method used

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  • Application of valnemulin hydrochloride
  • Application of valnemulin hydrochloride
  • Application of valnemulin hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 is the in vitro bacteriostatic test of warnemulin hydrochloride. The in vitro antibacterial effect of warnemulin hydrochloride against chicken pathogenic bacteria was determined by double dilution method. The in vitro antibacterial test showed that warnemulin hydrochloride had strong in vitro antibacterial activity against clinical isolates of Mycoplasma gallisepticum, Staphylococcus aureus, and Pasteurella avium, with MIC values ​​of 0.0027, 0.032, and 2.1 μg / mL, respectively. ; The control drug tiamulin fumarate was 0.05, 0.066, 15.7 μg / ml respectively.

[0018] The results showed that: warnemulin has a very low MIC value, and its antibacterial activity is obviously better than other clinical drugs.

Embodiment 2

[0019] Example 2 is a clinical trial of using warnemulin hydrochloride to treat chicken respiratory diseases (mixed infection of mycoplasma and Escherichia coli). A total of 160 Isa commercial chickens aged 2 weeks were selected, including half male and half female, and were randomly divided into 4 experimental groups, 40 chickens in each group. Myobectin was used as the control drug, and the curative effect of warnemulin hydrochloride premix was evaluated. According to the dosage of adding 400g, 200g, 100g warnemulin hydrochloride and 500g tiamulin fumarate in every ton of feed, it is divided into four drug groups, and the four drug groups are randomly selected as 4 groups of experimental groups. Both groups were fed with the sick chickens with the selected drug group, and the drug was used continuously for 5 days.

[0020] The results showed that warnemulin hydrochloride had a therapeutic effect on the mixed infection of Mycoplasma gallisepticum and Escherichia coli, the ef...

Embodiment 3

[0022] Example 3 is a clinical trial of using warnemulin hydrochloride to prevent chicken respiratory diseases (mycoplasma infection). Select 100 commercially healthy broiler chickens, including half male and half female, and randomly divide them into two groups, the test group I is the blank group, without drug use, and the test group II is the warnemulin hydrochloride treatment group, with 50 birds in each group. No medicine was given to the test group I, and the medicine was given to the test group II according to the requirements in Table-1. After 15 days of continuous administration, the two groups adopted the artificial challenge method of mycoplasma, and the food intake, drinking water and mental status of the chickens in each group were regularly observed every day. The experimental chickens were isolated and identified for pathogenic microorganisms one day after the artificial challenge. The test results are shown in Table 1. All the chickens in the test group I were ...

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Abstract

The invention provides an application of valnemulin hydrochloride which is utilized to prepare a medicine for treating and preventing chicken mycoplasma infection and bacterial infection diseases. The medicine prepared by the valnemulin hydrochloride is a premix, soluble powder and a solution. Compared with traditional technology, the valnemulin hydrochloride provided by the invention is applied to chicken respiratory disease and chicken bacterial infection disease, so that the treatment effect of the valnemulin hydrochloride is more significant and the two diseases can be completely healed under the reasonable dose; and the residual quantity of the medicine in the chicken bodies is very low after the chicken is healed, the healed chicken is free from drug resistance of the medicine, so that the medicine can be repeatedly utilized but the curative effect of the medicine is not influenced.

Description

technical field [0001] The invention relates to an application of warnemulin hydrochloride, in particular to an application for preparing a medicine for treating and preventing chicken mycoplasma infection and bacterial infectious diseases. Background technique [0002] With the continuous development of the large-scale chicken industry, some conditional pathogens, such as Mycoplasma gallisepticum, Escherichia coli, Salmonella, etc. in the rearing of dirty air, excessive density, immune stimulation, sudden changes in weather, sudden change of feed, vitamin deficiency Under the influence of unfavorable factors such as chicken flocks, the disease is caused, causing huge economic losses. [0003] Chicken mycoplasma infection is prevalent in chicken farms. According to serological surveys, the average infection rate of the virus is between 70% and 80%. Mycoplasma gallisepticum (MG) is the pathogen of Mycoplasma gallisepticum infection (Chicken Chronic Respiratory Disease CRD), ...

Claims

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Application Information

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IPC IPC(8): A61K31/22A61P31/04
Inventor 陈清平吴东林王铭宏
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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