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Cefaclor capsule and preparation method thereof

A technology of cefaclor capsules and keluo capsules, applied in the directions of capsule delivery, antibacterial drugs, etc., can solve the problems of low bioavailability and poor stability, and achieve the effects of convenient operation, low cost and stable product quality

Inactive Publication Date: 2012-11-28
HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the marketed preparations of cefaclor include tablets, capsules, granules, dispersible tablets, dry suspensions, sustained-release tablets and sustained-release capsules. Its poor stability and low bioavailability have always been difficult problems to solve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] (1) According to parts by weight, take 100 parts of cefaclor and pulverize it and pass through a 65-mesh sieve;

[0021] (2) Mix 10 parts of pregelatinized starch and 3 parts of silicon dioxide with the cefaclor powder above;

[0022] (3) Add 0.5 parts of magnesium stearate and mix well;

[0023] (4) Pack the mixed powder into capsules containing 125 mg or 250 mg of cefaclor each on a capsule packing machine, and pack the finished product after passing the test.

Embodiment 2

[0025] (1) According to parts by weight, take 100 parts of cefaclor and pulverize it and pass through a 65-mesh sieve;

[0026] (2) Mix 95 parts of pregelatinized starch and 2.5 parts of silicon dioxide with the cefaclor powder above;

[0027] (3) Add 2.5 parts of magnesium stearate and mix well;

[0028] (4) Pack the mixed powder into capsules containing 125 mg or 250 mg of cefaclor each on a capsule packing machine, and pack the finished product after passing the test.

Embodiment 3

[0030] (1) According to parts by weight, take 100 parts of cefaclor and pulverize it and pass through a 65-mesh sieve;

[0031] (2) Mix 98 parts of pregelatinized starch and 2.5 parts of silicon dioxide with the cefaclor powder above;

[0032] (3) Add 2.5 parts of magnesium stearate and mix well;

[0033] (4) Pack the mixed powder into capsules containing 125 mg or 250 mg of cefaclor each on a capsule packing machine, and pack the finished product after passing the test.

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PUM

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Abstract

The present invention relates to a cefaclor capsule and a preparation method thereof. The cefaclor capsule is composed by the following components by weight: 100 parts of cefaclor, 5-100 parts of pregelatinized starch, 1-5 parts of silica and 0.5-2.5 parts of magnesium stearate. The preparation method comprises: (1) sieving the cefaclor after pulverization; (2) mixing pregelatinized starch and silica with the sieved cefaclor powder uniformly; (3) adding magnesium stearate and mixing uniformly; and (4) making the mixed powder into capsules, and packing the qualified capsules into resulting products after detection. The sources of raw and auxiliary materials selected by the present invention are convenient. The auxiliary materials are few in types, are all commonly used auxiliary materials for preparations, and are low in prices. The production process is simple, and the operation is convenient and fast. The preparation process is simple, easy in operation, low in cost, and high in yield, and is suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of cephalosporin antibiotic capsules and preparation thereof, in particular to a cefaclor capsule and a preparation method thereof. Background technique [0002] Cefaclor is a second-generation oral cephalosporin, which has a strong killing effect on a variety of Gram-positive and Gram-negative bacteria. It is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is higher than that of cefadroxil 2 to 4 times stronger. The activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than cephalexin, similar to cefadroxil, and the activity against Proteus mirabilis, Salmonella and Shigell...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61P31/04
Inventor 孙志嘉王喜军杨新春刘妍
Owner HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY
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