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5-cyclopropyl-2-hydroxy-benzoic acid, its synthetic method and application method

A synthesis method and cyclopropyl technology are applied in chemical instruments and methods, applications, preparation of oxygenated compounds, etc., which can solve the problems of complex formula of fruit preservatives and limited fresh-keeping applications, and can ensure storage and quality, and can be titratable. The effect of decreasing acid content and increasing activity

Inactive Publication Date: 2012-11-28
李海涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention provides a kind of 5-cyclopropyl-2-hydroxyl-benzoic acid and its synthetic method and application, overcomes the above-mentioned deficiencies in the prior art, it can effectively solve the complex formula of the existing fruit preservatives, the limited application of fresh-keeping limit problem

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1, this 5-cyclopropyl-2-hydroxyl-benzoic acid, its molecular formula is: C 10 h 10 o 3 , the molecular weight is: 178.18, and the chemical structural formula is: .

Embodiment 2

[0028]Embodiment 2, the synthetic method of this 5-cyclopropyl-2-hydroxyl-benzoic acid is carried out according to the following steps: the first step, halogenation reaction: dissolve salicylic acid in glacial acetic acid, then add at room temperature bromine and stirred, and after the stirring was completed, suction filtration under reduced pressure was carried out. After suction filtration under reduced pressure, a light yellow solid filter cake was obtained, and the light yellow solid filter cake was recrystallized with water or ethanol to obtain white crystals. The white crystals were 5-bromo-2- Hydroxy-benzoic acid;

[0029] The second step, alkylation or esterification reaction: suspend 5-bromo-2-hydroxy-benzoic acid and potassium carbonate in acetone, and then add dimethyl sulfate at room temperature and then at a temperature of 70 degrees Celsius to 75 degrees Celsius Stir and reflux overnight, after stirring and reflux overnight, cool to room temperature and carry out...

Embodiment 3

[0033] Embodiment 3, the synthetic method of this 5-cyclopropyl-2-hydroxyl-benzoic acid is carried out as follows: the first step, halogenation reaction: dissolve 13g to 15g salicylic acid in every 250ml glacial acetic acid, then Add 15g to 17g of bromine at room temperature and stir. After the stirring is completed, perform vacuum filtration. After vacuum filtration, a light yellow solid filter cake is obtained. Recrystallize the light yellow solid filter cake with water or ethanol to obtain white crystals, white crystals is 5-bromo-2-hydroxy-benzoic acid;

[0034] The second step, alkylation or esterification reaction: Suspend 12g to 14g of 5-bromo-2-hydroxy-benzoic acid and 19g to 21g of potassium carbonate in every 150ml of acetone, then add 13ml to 15ml of sulfuric acid disulfide at room temperature After the methyl ester was stirred and refluxed overnight at a temperature of 70 degrees Celsius to 75 degrees Celsius, after the stirring and refluxed overnight, it was coole...

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Abstract

The invention, relating to the technical field of synthesizing 5-cyclopropyl-2-hydroxy-benzoic acid by using salicylic acid, discloses 5-cyclopropyl-2-hydroxy-benzoic acid, its synthetic method and application method. The 5-cyclopropyl-2-hydroxy-benzoic acid is represented by C10H10O3, and has a molecular weight of 178.18. According to the invention, the process of synthesizing the 5-cyclopropyl-2-hydroxy-benzoic acid is simple with high yield, the application of the 5-cyclopropyl-2-hydroxy-benzoic acid in agricultural food preservation has significant effect, and the fruit respiration can be inhibited after using the 5-cyclopropyl-2-hydroxy-benzoic acid to process the fruits to increase the activity of polyphenoloxidase, effectively reduce the fruit hardness, and reduce the content of titratable acids, thus the storage and quality of the fruits are guaranteed.

Description

technical field [0001] The invention relates to the technical field of synthesizing 5-cyclopropyl-2-hydroxy-benzoic acid with salicylic acid, and relates to 5-cyclopropyl-2-hydroxy-benzoic acid and its synthesis method and application. Background technique [0002] Salicylic acid (Salicylic Acid, referred to as SA), is a simple phenolic compound widely present in higher plants. Aging; can effectively maintain the quality of fruits and vegetables; enhance the cold resistance of fruits; induce postharvest fruit resistance enzyme activity. However, salicylic acid is easily decomposed into phenol and carbon dioxide under normal pressure conditions, which is not easy to store and use, which restricts the application of salicylic acid in fresh-keeping function. In addition to common preservatives, some compound preservatives have appeared in the market at present, but the application of compound preservatives is limited due to the complexity of the formula. Contents of the inve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C65/05C07C27/02A23B7/154
Inventor 李海涛连召斌沈燕
Owner 李海涛
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