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Aralia taibaiensis saponin capsule, as well as preparation method and application thereof in preparation of antidiabetic medicines

A technology of Aralia taibai and capsules, which can be used in capsule delivery, drug combination, metabolic diseases, etc. It can solve problems such as improper control of the dosage of hypoglycemic drugs, excessive fluctuations, and blood sugar drop, and achieve solvent and energy saving and hygroscopicity. Reduce, reduce the effect of high blood sugar

Inactive Publication Date: 2012-12-19
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, middle-aged and elderly patients with type 2 diabetes with both Qi and Yin deficiency have obvious symptoms such as dizziness and fatigue. It will make dizziness and fatigue more obvious

Method used

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  • Aralia taibaiensis saponin capsule, as well as preparation method and application thereof in preparation of antidiabetic medicines
  • Aralia taibaiensis saponin capsule, as well as preparation method and application thereof in preparation of antidiabetic medicines
  • Aralia taibaiensis saponin capsule, as well as preparation method and application thereof in preparation of antidiabetic medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 100g of dried Aralia taibai root bark was crushed and passed through a 80-mesh sieve to obtain fine powder of Aralia taibai medicinal material, and then extracted and refluxed 3 times at 80°C with 6 times the weight and 70% ethanol by mass percentage concentration, each time 1 h; after the extract is filtered, combined and concentrated to a relative density of 1.01, then extracted 3 times with water-saturated n-butanol at a volume ratio of 1:1, the n-butanol layer is filtered, combined and concentrated to obtain the total saponins of Aralia japonica Aralia taibai extract extract with a mass percentage of 60-80%, the extract is dried in a vacuum dryer at 50°C, and crushed to obtain dry extract powder.

Embodiment 2

[0040] Weigh respectively 6.25g of aralia saponin extract dry extract powder that crosses 100 mesh sieves, starch 9.375g that crosses 100 mesh sieves, and microcrystalline cellulose 9.375g, after mixing uniformly with equal addition method, use 75% ethanol for Soft material made of wetting agent, passed through a 40-mesh sieve, dried in an oven at 50°C for 6 hours, took out the dry granules, sieved through a 40-mesh sieve, sieved the fine powder, and filled the obtained granules into No. 1 capsules to obtain the product;

Embodiment 3

[0042] Similar to Example 2, take respectively 6.25g of aralia saponin extract, 18.75g of dextrin, and 6.25g of microcrystalline cellulose that have passed through a 100-mesh sieve. Prepare soft materials, pass through a 40-mesh sieve, dry in an oven at 50°C for 7 hours, take out the dry granules, sieve through a 40-mesh sieve, sieve the granules, remove fine powder through a 60-mesh sieve, and fill the obtained granules into No. 1 capsules.

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Abstract

The invention discloses a preparation method of a medicine capsule taking aralia taibaiensis extracts as active pharmaceutical ingredients to treat diabetes. The preparation method comprises the following main processes of: uniformly mixing aralia taibaiensis extracts treated with a 100-mesh sieve with auxiliary materials, then preparing softwood with 70-90% ethanol as a wetting agent, treating the softwood with a 40-mesh sieve, drying wet granules in an oven at 50-60 DEG C for 5-7 hours, straightening the granules with the 40-mesh sieve and a 60-mesh sieve respectively and filling the obtained granules into a No.1 capsule, thus obtaining the medicine capsule. The preparation method has the following advantages and positive effects that aiming at the problems that as the traditional Chinese medicine extracts have strong moisture absorption, the traditional Chinese medicine extracts easily absorb moisture, have poor flowability and are hard to disintegrate in the capsule preparation process, the medicine capsule is obtained by investigating the prescription composition and the preparation processes, selecting the best auxiliary materials and adopting the optimum preparation processes; by adopting the preparation processes, the moisture absorption of aralia taibaiensis saponins is obviously reduced, the medicine is more stable and the curative effect is more reliable; and the processes are simple to operate, the repeatability is good, the production cycle is short, the auxiliary material cost is low and the solvents and energy are saved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Taibai aralia saponin capsule and a preparation process thereof for treating middle-aged and young people or moderate type II diabetes with deficiency of both qi and yin. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by chronically elevated blood glucose levels. It is characterized by high morbidity, disability and complications. Diabetes, together with cardiovascular disease and cancer, is known as the three major diseases that endanger human health. The hypoglycemic effect of Western medicine is outstanding, but there are certain limitations and adverse reactions, and even serious side effects, such as hypoglycemia, lactic acidosis, liver and kidney toxicity, etc. Therefore, it is the goal pursued by medical experts to find high-efficiency and low-toxic hypoglycemic drugs . Natural...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61K9/48A61P3/10
Inventor 文爱东翁琰奚苗苗崔佳王艳华陆杨
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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