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Preparation method of beta-cyclodextrin inclusion compound-containing electrospun fiber

A technology of cyclodextrin inclusion compound and electrospun fiber, which is applied in fiber treatment, fiber chemical characteristics, conjugated synthetic polymer artificial filament, etc., can solve uneven dispersion of drugs, easy pollution of the environment, agglomeration and burst release and other problems, to achieve the effect of smooth and uniform surface, low cost and increased solubility

Inactive Publication Date: 2013-01-02
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But so far, most of this kind of research has focused on the loading and controlled release of hydrophilic drugs. When using hydrophobic components, or using organic solvents that are easy to pollute the environment and harmful to the human body to obtain a good dispersion effect, or Water is used as the solvent, but there will be problems such as uneven drug dispersion, agglomeration and burst release (Taepaiboon, P; Rungsardthong, U; Supaphol, P.Drug-loaded electrospun mats of poly(vinyl alcohol) fibers and their release characteristics of four model drugs, 2006, 17(9):2317-2329)

Method used

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  • Preparation method of beta-cyclodextrin inclusion compound-containing electrospun fiber
  • Preparation method of beta-cyclodextrin inclusion compound-containing electrospun fiber

Examples

Experimental program
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Effect test

Embodiment 1

[0027] (1) Preparation of β-cyclodextrin inclusion compound: Dissolve indomethacin in an appropriate amount of acetone or ethyl acetate, and slowly add to β-cyclodextrin saturated aqueous solution at 70°C (n 吲哚美辛 :n β-环糊精 =1:2), and stirred at constant temperature for 4 hours. After standing for 6 hours, stand in the refrigerator at 4°C for 12 hours, filter, wash, and dry to constant weight.

[0028] (2) Configuration of spinning solution: dissolve the water-soluble polymer polyvinylpyrrolidone in water, configure a 12wt% solution, add 20wt% (relative to the polymer) cyclodextrin inclusion compound obtained in step ①, continue Stir for 6 hours to obtain a spinning solution.

[0029] (3) Electrospinning: 10Kv, 1.5ml / h, humidity 40%, receiving distance 15cm. The diameter of the obtained fiber is 150-400nm, the release of indomethacin is slow, and the half-life is close to 24 hours.

Embodiment 2

[0031] (1) Preparation of β-cyclodextrin inclusion compound: Dissolve curcumin in an appropriate amount of acetone, and slowly add it to β-cyclodextrin saturated aqueous solution at 45°C (n 姜黄素 :n β-环糊精 =1:2), reflux at 50°C for 4 hours, lower to room temperature and continue to stir for 8 hours, stand at 4°C for 12 hours, filter, wash, and dry to constant weight.

[0032] (2) Configuration of spinning solution: dissolve the water-soluble polymer polyvinyl alcohol in water at 90°C, prepare a 10wt% solution, add 20-50wt% (relative to the polymer) cyclodextrin inclusion compound obtained in step ①, Stirring was continued for 8 hours to obtain a spinning solution.

[0033] (3) Electrospinning: 15Kv, 0.5ml / h, humidity 35%, receiving distance 20cm.

Embodiment 3

[0035] (1) Preparation of β-cyclodextrin inclusion compound: Mix β-cyclodextrin and water at a molar ratio of 1:2, add phenobarbital and mix well (n 苯巴比妥 :n β-环糊精 =1:1), ground into paste, dried at 35°C, washed and then dried to obtain β-cyclodextrin inclusion compound.

[0036] (2) Configuration of spinning solution: Dissolve water-soluble polymer polyvinyl alcohol in water at 90°C, prepare 8wt% solution, add 30wt% (relative to polymer) cyclodextrin inclusion compound obtained in step ①, and continue stirring A spinning solution was obtained in 10 hours.

[0037] (3) Electrospinning: 20Kv, 1ml / h, humidity 45%, receiving distance 25cm.

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Abstract

The invention relates to a preparation method of beta-cyclodextrin inclusion compound-containing electrospun fiber, which comprises the steps of: (1) preparing beta-cyclodextrin inclusion compound by a saturated water aqueous solution method or a grinding method; and (2) mixing water-soluble polymer solution with the prepared beta-cyclodextrin inclusion compound, and stirring to obtain spinning solution; and after that, carrying out electrostatic spinning to obtain the beta-cyclodextrin inclusion compound-containing electrospun fiber. The preparation method is simple and low in cost; the preparation method of the electrospun fiber can evenly disperse hydrophobic components, and is environment-friendly; the inclusion compound has good wettability, increases the solubility of medicine and improves the dispersion effect of the medicine in the spinning solution as well as the quality of the obtained electrospun fiber; and the electrospun fiber is smooth and uniform in surface, reduces the dosage of organic solvent and avoids the burst release of directly-loaded medicine.

Description

technical field [0001] The invention belongs to the field of preparation of electrospun fibers, in particular to a preparation method of electrospun fibers containing β-cyclodextrin inclusion compound. Background technique [0002] In recent years, drug delivery systems based on electrospun nanofibers have attracted widespread attention and interest at home and abroad. Its characteristics mainly include: ① high specific surface area and high porosity brought by the continuous three-dimensional space network structure; ② by choosing an appropriate spinning system, the drug can exist in an amorphous form in the fiber; ③ as a macroscopic ( The combination of axial) and microscopic (radial), the nano drug-loaded fiber membrane has the advantages of the stability of solid preparations, the advantages of easy handling, packaging and transportation of macroscopic preparations, and the pharmacology and Pharmacokinetic characteristics. Therefore, the development and research of dru...

Claims

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Application Information

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IPC IPC(8): D01F8/18D01F8/10D01F8/02D01F8/16D01F1/10D01D5/00
Inventor 朱利民孙晓竹侯晓晓
Owner DONGHUA UNIV
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