Real-time portable forward photoacoustic microscope

A photoacoustic microscope, portable technology, used in microscopes, optics, optical components, etc., can solve the problems of difficult miniaturization and portable design, large laser size, high price, and achieve simple signal post-processing circuits, large imaging depth, and high price. low effect

Inactive Publication Date: 2013-01-02
曾吕明
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  • Abstract
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  • Claims
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Problems solved by technology

The above reports all use laser galvanometers to realize beam scanning instead of mechanical scanning to achieve fast imaging, but they all use relatively high-power solid-state lasers as photoacoustic excitation sources, and such lasers usually have large volume, high price, There are many shortcomings such as difficult maintenance, and it is difficult to realize the miniaturization and portable design of the system, which obviously has considerable limitations in practical applications

Method used

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  • Real-time portable forward photoacoustic microscope

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Embodiment 1

[0020] Embodiment 1 The structure of this embodiment is as follows figure 1 As shown, the names of each component are: 1. Laser diode, 2. Collimating lens, 3. Multi-dimensional laser vibrating mirror, 4. Focusing lens, 5. Protective mirror, 6. Housing, 7. Stage, 8. Ultrasonic Coupling liquid, 9. Ultrasonic sensor, 10. Signal preprocessing circuit, 11. Data acquisition circuit, 12. Computer, 13. Vibrating mirror driving circuit, 14. Clock circuit, 15. Driving power circuit.

[0021] Among them, the laser diode 1 is a pulsed semiconductor laser diode (PFAS1S12, PerkinElmer), the working wavelength is 850nm, and the single pulse energy is about 3.9uJ; the ultrasonic sensor 9 is a 256-element surface array probe with a hollow structure (5M16*16-1.0*1.0 , Guangzhou Doppler Electronic Technology Co., Ltd.), the center frequency is 5.0MHz, the effective aperture is 16mm, and the shell model is B16; the focusing lens 4 adopts an aspheric lens with a numerical aperture as high as 0.62,...

Embodiment 2

[0035] Embodiment 2 An optical resolution photoacoustic microscope based on beam scanning is similar in structure to Embodiment 1, except that the ultrasonic sensor 9 adopts a hollow-structure unit angled probe (5.0 P9×9K1), the center frequency is 5.0MHz, the size is 9 mm×9 mm, and the external interface adopts Q9 (BNC) interface.

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Abstract

The invention provides a portable forward photoacoustic microscope based on optical resolution. The photoacoustic microscope comprises a laser diode, a collimating lens, a focusing lens, protective glasses, a shell, an objective table, an ultrasonic coupling liquid, an ultrasonic sensor, a lifting platform, a 3D motorized translation stage, a motor drive circuit, a computer, a data acquisition circuit, a signal pre-treatment circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution photoacoustic microscopy excitation. The portable forward photoacoustic microscope has the advantages of portable volume, high resolution, large imaging depth and simple signal post-treatment circuit, and is quite suitable for nondestructive testing of thin materials or tissue samples.

Description

technical field [0001] The invention relates to a photoacoustic microscopic imaging technology, in particular to a real-time portable forward photoacoustic microscope. Background technique [0002] Photoacoustic microscopy imaging is a newly developed imaging technology, which can realize high-resolution detection images on the scale of hundreds of microns to tens of nanometers, and has the advantages of high optical contrast, no radiation damage, and safe and convenient use. The lateral resolution of resolution photoacoustic microscopy imaging is mainly determined by the focal spot size of the incident laser light, and has nothing to do with the receiving main frequency of the sensor. The smaller the focal spot diameter, the higher the resolution, which can theoretically be close to the near optical diffraction limit ( or limit point), and its imaging depth is mainly determined by the optical scattering coefficient of the measured sample. The lateral resolution of acoustic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/17G02B21/36
Inventor 曾吕明杨迪武纪轩荣
Owner 曾吕明
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