Real-time portable forward photoacoustic microscope

Abstract

The invention provides a portable forward photoacoustic microscope based on optical resolution. The photoacoustic microscope comprises a laser diode, a collimating lens, a focusing lens, protective glasses, a shell, an objective table, an ultrasonic coupling liquid, an ultrasonic sensor, a lifting platform, a 3D motorized translation stage, a motor drive circuit, a computer, a data acquisition circuit, a signal pre-treatment circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution photoacoustic microscopy excitation. The portable forward photoacoustic microscope has the advantages of portable volume, high resolution, large imaging depth and simple signal post-treatment circuit, and is quite suitable for nondestructive testing of thin materials or tissue samples.

Description

technical field [0001] The invention relates to a photoacoustic microscopic imaging technology, in particular to a real-time portable forward photoacoustic microscope. Background technique [0002] Photoacoustic microscopy imaging is a newly developed imaging technology, which can realize high-resolution detection images on the scale of hundreds of microns to tens of nanometers, and has the advantages of high optical contrast, no radiation damage, and safe and convenient use. The lateral resolution of resolution photoacoustic microscopy imaging is mainly determined by the focal spot size of the incident laser light, and has nothing to do with the receiving main frequency of the sensor. The smaller the focal spot diameter, the higher the resolution, which can theoretically be close to the near optical diffraction limit ( or limit point), and its imaging depth is mainly determined by the optical scattering coefficient of the measured sample. The lateral resolution of acoustic...

AI Technical Summary

Problems solved by technology

The above reports all use laser galvanometers to realize beam scanning instead of mechanical scanning to achieve fast imaging, but they all use relatively high-power solid-state lasers as photoacoustic excitation sources, and such lasers usually have large volume, high price, There are many shortcomings such as difficult maintenance, and it is difficult to realize the miniaturization and portable design of the system, which obviously has considerable limitations in practical applications

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