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Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation

A technology of traditional Chinese medicine preparations and pneumonia, applied in the field of preparation of medicines and their preparations, can solve problems affecting the absorption and utilization of active ingredients of medicines, slow release of active ingredients of raw materials, and inability to ensure stable and uniform quality of this product

Inactive Publication Date: 2013-01-09
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The existing preparation of Jiuwei Limehua Powder is crushed and then used as medicine without extraction. The active ingredients of the raw material drug are released slowly, which seriously affects the absorption and utilization of the active ingredients of the drug.
There are currently no identification and content determination items in the existing quality control methods for Jiuwei Limehua powder, so the quality of this product cannot be guaranteed to be stable and uniform

Method used

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  • Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation
  • Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation
  • Pharmaceutical for treating pneumonia, as well as preparation method and quality control method of pharmaceutical formulation

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0044] Experimental example 1: Comparison of different extraction methods

[0045] A. Water extraction:

[0046] (1) Take safflower and sandalwood according to the composition ratio of raw materials, add 8 times the weight of water, use steam distillation method, extract volatile oil for 4 hours, collect volatile oil, filter the medicinal liquid, and obtain extract A' and medicinal residue A;

[0047] Add the collected volatile oil into 4% β-cyclodextrin aqueous solution by weight and volume, the volume-to-weight ratio of volatile oil to β-cyclodextrin is 1ml: 4g, under stirring conditions, keep the temperature at 50°C, stir for 4h, 0°C-4 Refrigerate at ℃ overnight, filter with suction, and take the precipitate to obtain the clathrate B of volatile oil;

[0048] (2) Take a total of 6 medicinal materials according to the composition ratio of raw materials: Travertine, Rhodiola, Bangga, Licorice (peeled), Alpine horseradish, and Honglian, and mix with the medicinal residue A af...

experiment example 2

[0059] Experimental example 2: Selection of different excipients

[0060] Take artificial bezoar and the volatile oil clathrate B obtained by the water extraction method of the above-mentioned experimental example 1 according to the composition ratio of the raw material drug, add it to the liquid extract C obtained by the water extraction method of the above-mentioned experimental example 1, mix well with a colloid mill, and add sucrose respectively , dextrin, soluble starch, lactose as auxiliary materials, one-step granulation with boiling spray to prepare granules;

[0061] Table 3 Effects of different excipients and dosages on granules

[0062]

[0063] Note: The amount of auxiliary materials refers to the weight percentage of the finished granules

[0064] The results show that it is more suitable to use sucrose and dextrin as auxiliary materials, and the obtained particles are uniform and suitable, and the dosage can be 50%-80%.

experiment example 3

[0065] Experimental example 3: Selection of different granulation processes

[0066] Prepare volatile oil clathrate B and liquid extract C according to the method of Example 1, and mix them with artificial bezoar, use dextrin as an auxiliary material, and the dosage is 60% of the finished granules, and adopt one-step granulation and wet granulation respectively to prepare Granules, the resulting granules measure the loss of active ingredient;

[0067] Table 4 Effect of different granulation methods on active ingredients

[0068] Granulation process Loss rate of hydroxysafflower yellow A (%) Loss rate of salidroside (%) one step granulation 1.6 2.1 wet granulation 13.8 7.5

[0069] The results showed that there was almost no loss of active ingredients in one-step granulation, but the loss of active ingredients in wet granulation, especially hydroxysafflower yellow A, was more serious, so it was determined to adopt one-step granula...

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Abstract

The invention relates to a pharmaceutical for treating pneumonia, and a preparation method of a Chinese medicine formulation, in particular a nine-component travertine particle formulation which is prepared by formulation improvement. The technical scheme is as follows: an extraction process is optimized and sifted, modern novel equipment, novel technologies and novel methods are technically adopted, and the pharmaceutical is suitable for industrial large-scale production; quality standard researches are improved based on the original standard; thin-layer identification, content determination methods and ester-series alkaloid limit test methods are newly set out; and the product quality standard is advanced and controllable, and the clinical effects and the safety of drug use are guaranteed.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, relates to a traditional Chinese medicine, in particular to a medicine for treating pneumonia and a preparation method and a quality control method of the preparation thereof. Background technique [0002] Pneumonia refers to inflammation of the terminal airways, alveoli and interstitium of the lung. Its symptoms: fever, shortness of breath, persistent dry cough, may have unilateral chest pain, chest pain when taking a deep breath and coughing, a small amount of sputum or a large amount of sputum, which may contain blood streaks. Pneumonia can be caused by pathogenic microorganisms such as bacteria, viruses, fungi, and parasites, as well as physical and chemical factors such as radiation and inhaled foreign bodies. After bacterial pneumonia is treated with appropriate antibiotics, it can be cured within seven to ten days, but there are also problems such as allergies, si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P11/00G01N30/90G01N30/02
Inventor 邵成明
Owner TAISHAN MEDICAL UNIV
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