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Chinese medicinal injection for treating jaundice and preparation method thereof

The technology of injection and traditional Chinese medicine is applied in the field of traditional Chinese medicine injection for treating jaundice and its preparation, which can solve the problems of large side effects, insignificant curative effect and high treatment cost, and achieve the effect of eliminating worries and achieving good therapeutic effect.

Active Publication Date: 2014-07-23
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, anti-jaundice drugs mainly include western medicines: ursodeoxycholic acid, adenosylmethionine, anetis trisulfide, potassium magnesium aspartate, etc., but due to the high cost of treatment, the curative effect is not significant, and the side effects are large, they cannot be taken for a long time.

Method used

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  • Chinese medicinal injection for treating jaundice and preparation method thereof
  • Chinese medicinal injection for treating jaundice and preparation method thereof
  • Chinese medicinal injection for treating jaundice and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: The preparation of Chinese medicine injection of the present invention:

[0027] A preparation method of a traditional Chinese medicine injection for the treatment of jaundice, comprising the steps of:

[0028] (1), take by weighing 500g of capillary root, 200g of Gardenia, 150g of Radix Scutellariae, 10g of Coptis Rhizoma, 40g of Phellodendron Phellodendri and 100g of Rheum officinalis;

[0029] (2) Decoct capillary, gardenia, scutellaria baicalensis and rhubarb twice, add 6 times of water for the first time, decoct for 1.5h, add 4 times of water for the second time, decoct for 1.0h, combine the second decoction , concentrated to 250mL, to obtain a concentrated solution with a thermally measured relative density of 1.10-1.30g / mL at 50°C; add ethanol to the concentrated solution, and ethanol precipitation twice, of which 4 times the amount of 90-92% ethanol was added for the first time, and stirred evenly , stand still for more than 48 hours, separate the ...

Embodiment 2

[0033] Example 2: Determination of total solids in traditional Chinese medicine injections:

[0034]Total solids: Accurately measure 10 mL of the traditional Chinese medicine injection prepared in Example 1, place it in an evaporating dish with constant weight in advance, evaporate to dryness in a water bath, dry at 105°C for 3 hours, and then cool it in a desiccator for 0.5 hours, take it out, and quickly obtain a fixed weight , calculated to obtain the total solid content in the traditional Chinese medicine injection. Each 1mL injection of this product contains ≥16mg of total solids.

Embodiment 3

[0035] Embodiment 3: Geniposide C 17 h 24 o 11 Content determination:

[0036] Geniposide: Determination according to high performance liquid chromatography.

[0037] Chromatographic conditions and system suitability test: Octadecylsilane combined with silica gel was used as filler, methane-water (25:75) was used as mobile phase, and the detection wavelength was 242nm. The number of theoretical plates calculated by geniposide should not be less than 1800.

[0038] Preparation of reference substance solution: Accurately weigh 5 mg of geniposide reference substance, place in a 5mL measuring bottle, add methanol to dilute to the mark, and shake well; accurately measure 1 mL, place in a 10mL measuring bottle, add methanol to dilute to the mark, shake Mix well to obtain (every 1 mL contains 100 μg of geniposide).

[0039] The preparation of need testing solution: precision measures the Chinese medicine injection 3mL that embodiment 1 prepares gained, is placed in 10mL measur...

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Abstract

The invention discloses a Chinese medicinal injection for treating jaundice and a preparation method thereof, which belong to the technical field of Chinese medicinal preparations. The preparation method of the Chinese medicinal injection comprises the following steps of: performing water cooking and alcohol deposition on virgate wormwood herb, fructus gardenia, baikal skullcap root and coptis root to obtain an acid alcohol liquid, performing ethanol percolation on amur corktree bark and rhubarb to obtain an ethanol percolate, mixing the acid alcohol liquid with the ethanol percolate, performing alcohol deposition, adding a concentrated ammonium solution for adjusting the pH value to 8.0-9.0, extracting a supernatant to obtain an alkaline alcohol liquid, concentrating under reduced pressure, and recovering ethanol to obtain a liquid medicament; and adding a proper amount of water for injection into the liquid medicament, filtering and sterilizing to obtain a Chinese medicinal injection for treating jaundice, wherein every 1mL of Chinese medicine injection contains more than or equal to 1.0mg of geniposide C17H24011. The Chinese medicinal injection provided by the invention has the advantage of good treatment effect on jaundice of chronic virus B hepatitis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine injection for treating jaundice and a preparation method thereof. Background technique [0002] my country is a big country with viral hepatitis. There are more than 120 million long-term carriers of hepatitis B virus (HBV), and about 280,000 liver patients die of HBV infection every year. The treatment of viral hepatitis is mainly antiviral, but in clinical practice, it is common to have persistent jaundice in the advanced stage of chronic disease, which can lead to liver cirrhosis and even liver failure in severe cases. Removal of jaundice can delay the course of viral liver disease and improve the quality of life of patients. At present, anti-jaundice drugs mainly include western medicines: ursodeoxycholic acid, adenosylmethionine, anetis trisulfide, potassium magnesium aspartate, etc., but all of them cannot be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/756A61P1/16
Inventor 韩晋周旭
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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