Preparation method of fat-soluble chemotherapeutic medicament loaded on calcium phosphate nano carrier and application of fat-soluble chemotherapeutic medicament in preparation of antitumor medicaments

Abstract

The invention discloses a preparation method of a fat-soluble chemotherapeutic medicament loaded on a calcium phosphate nano carrier. The preparation method comprises the following steps of: sequentially adding calcium salt water solution, phosphate water solution and fat-soluble chemotherapeutic medicament solution into distilled water; stirring by magnetic force; and carrying out reaction to obtain calcium phosphate nanoparticles of the fat-soluble chemotherapeutic medicament, wherein the calcium phosphate nanoparticles have the particle sizes less than 200nm. According to the preparation method, the calcium phosphate nanoparticles are firstly prepared by a chemical precipitation method in a single system, and then the fat-soluble chemotherapeutic medicament is absorbed, so that the water-soluble calcium phosphate nanoparticles for loading the fat-soluble chemotherapeutic medicament can be prepared and is suitable for intravenous injection. The prepared chemotherapeutic medicament is high in water solubility and good in dispersity, can promote the fat-soluble chemotherapeutic medicament to be effectively transmitted in the blood, and eliminates the toxic and side effects of the medicament; meanwhile, the preparation method is simple and easy to operate, high in stability and low in cost. The invention also relates to the application of the chemotherapeutic medicament prepared by the method in preparation of antitumor medicaments.

Description

technical field [0001] The present invention relates to a preparation method and application of a chemotherapeutic drug with anti-tumor activity, in particular to a preparation method of a novel fat-soluble chemotherapeutic drug loaded on a calcium phosphate nanocarrier, and the fat-soluble chemotherapeutic drug prepared by the method is used in Applications in the field of antitumor. Background technique [0002] Malignant tumors are one of the major diseases that affect human health. In recent years, with the influence of various factors such as living habits, eating habits, and environmental deterioration, the incidence of malignant tumors has been on the rise. According to WHO statistics, as of 2008, a total of 7.6 million people died of cancer in the world, accounting for about 13% of the total number of deaths from various diseases. It is estimated that by 2030, 11 million people worldwide will die of cancer (taken from the official website of WHO) . [0003] So far,...

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Problems solved by technology

[0009] The purpose of the present invention is to overcome the shortcomings of many side effects caused by chemotherapeutic drugs in clinical use due to their poor water solubility, and at the same time combine the principle of improving the anti-tumor activity of chemotherapeutic drugs in the clinical treatment process, and introduce calcium phosphate nanocarriers into chemotherapy. In the application research, a water-soluble calcium phosphate carrier loaded with fat-soluble chemotherapeutic drugs with clinical application prospects was prepared, and this achievement was applied in the field of chemotherapy, that is, this application will provide a lipid-soluble calcium phosphate carrier loaded on a water-soluble calcium phosphate carrier. Preparation method of soluble chemotherapeutic drug and its application in preparation of chemotherapy intravenous injection, the carrier can achieve the purpose of effectively transporting fat-soluble chemotherapeutic drug in blood and enhancing its physiological compatibility

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