High-strength absorbable magnesium substrate composite orthopedic fixing device and preparation method thereof

An internal fixator, high-strength technology, applied in the direction of internal fixator, fixator, medical science, etc., can solve problems such as difficult to meet mechanical safety requirements

Inactive Publication Date: 2013-02-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite material has a wider range of use and better strength and safety than the currently clinically used absorbable polylactic acid orthopedic devices

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1

[0037] The MB8 magnesium alloy is formed by die-casting and processed into a porous magnesium alloy matrix with a gradient distribution of pore structure. The external surface porosity of the porous magnesium alloy matrix is ​​35%-40%, the pore diameter is about 1mm, and the core porosity is 10%. -15%, the pore size is about 0.2mm; use 10g / L sodium silicate and 2g / L NaOH as the micro-arc oxidation electrolyte system, immerse the porous magnesium alloy matrix in it, apply 400V voltage, and perform micro-arc oxidation for 10 minutes Treat it to form a layer of 10μm thick magnesium oxide bioceramic underlayer on the surface and internal pore walls in situ; according to the weight percentage, the porous magnesium alloy matrix accounts for 75% and the molecular weight 900,000 polylactic acid accounts for 25%. Weigh appropriate amounts respectively The porous magnesium alloy matrix and the polylactic acid polymer material, and the porous magnesium alloy matrix is ​​f...

Example Embodiment

[0038] Example 2

[0039] The QE22 magnesium alloy is mechanically punched into a porous magnesium alloy matrix with a gradient distribution of pore structure. The surface porosity of the porous magnesium alloy matrix is ​​30%-35%, the pore diameter is about 1.2mm, and the core porosity is 15 %-20%, the pore diameter is about 0.3mm; use 10g / L sodium silicate, 3g / L hydroxyapatite nano powder, 3g / L NaOH as the micro-arc oxidation electrolyte system, immerse the porous magnesium alloy matrix in it, Apply 400V voltage and conduct micro-arc oxidation treatment for 15 minutes to form a layer of about 20μm thick magnesium oxide and hydroxyapatite composite ceramic bottom layer on the surface and internal pore walls; the porous magnesium alloy matrix accounts for 70% by weight %, the polylactic acid with a molecular weight of 700,000 accounts for 30%, weigh the appropriate amount of porous magnesium alloy matrix and polylactic acid polymer material, and fix the porous magnesium alloy mat...

Example Embodiment

[0040] Example 3

[0041] The AE21 magnesium alloy is formed by die-casting and processed into a porous magnesium alloy matrix with a gradient distribution of pore structure. The external surface porosity of the porous magnesium alloy matrix is ​​25%-30%, the pore diameter is about 1mm, and the core porosity is 10%. -15%, the pore diameter is about 0.2mm; use 10g / L sodium silicate, 3g / L hydroxyapatite nanopowder, 3g / L NaOH as the micro-arc oxidation electrolyte system, immerse the porous magnesium alloy matrix in it, and apply 400V voltage, 15 minutes of micro-arc oxidation treatment, on the surface and internal pore walls to form a layer of about 20μm thick magnesium oxide and hydroxyapatite composite ceramic substrate in situ; the porous magnesium alloy matrix accounts for 65% by weight , Polylactic acid with a molecular weight of 500,000 accounts for 35%, weigh the appropriate amount of porous magnesium alloy matrix and polylactic acid polymer material, and fix the porous magn...

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Abstract

The invention relates to a high-strength absorbable magnesium substrate composite orthopedic fixing device and a preparation method thereof. The fixing device is mainly formed by bonding and solidifying a low-porosity porous magnesium alloy substrate of which a pore structure presents a regular gradient distribution and a lower-content polylactic acid high-polymer material filled in the pore structure of the low-porosity porous magnesium alloy substrate, wherein the pore structure in the porous magnesium alloy substrate presents a gradient distribution that the porosity is gradually reduced from the surface of the magnesium alloy substrate to a core part or from the edge to the center, and the size of a pore is gradually diminished; and according to the calculation in percentage by weight, the polylactic acid of the high-polymer material for filling accounts for 5-49.9 percent of total weight, and the porous magnesium alloy substrate accounts for 50.1-95 percent of total weight. The fixing device is closer to magnesium alloy in strength, has the advantages of controllable in-body adsorption speed, slow-quick degradation, less hydrogen evolution moderate quantity and the like, is particularly suitable for the bone trauma surgery with high strength requirement and big volume, the bone defect repair surgery, the plastic surgery and other absorbable orthopedic fixed implantable devices applied to the clinical.

Description

technical field [0001] The invention relates to a high-strength absorbable magnesium-based composite orthopedic internal fixator, in particular to a low-porosity porous magnesium alloy matrix whose pore structure presents a gradient regular distribution and the lower content of the pore structure filled The polylactic acid polymer material is made by high-temperature bonding and solidification, in which the pore structure in the porous magnesium alloy matrix shows that the porosity gradually decreases from the surface of the magnesium alloy matrix to the core or from the edge to the center, and the pore size gradually decreases. gradient distribution. The invention has the advantages of high strength, controllable absorption rate in the body, slow first and then fast degradation, less hydrogen evolution relaxation, etc., and is especially suitable for clinical applications such as bone trauma surgery, bone defect repair surgery, and plastic surgery with high strength requireme...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/02A61L31/08A61B17/68
Inventor 储成林薛烽郭超白晶盛晓波董寅生林萍华
Owner SOUTHEAST UNIV
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