A radiolabeled polypeptide complex and its preparation method and application

A ligand compound and product technology, applied in the production of peptides and bulk chemicals, can solve the problems of inability to detect biochemical changes in tumor tissue, affect the imaging quality of tracers, poor specificity and sensitivity, and achieve easy automatic synthesis , Improve pharmacokinetic properties, increase the effect of target uptake
CN102911256BActive Publication Date: 2016-06-01NANTONG SHIMEIKANG PHARMA CHEM
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
NANTONG SHIMEIKANG PHARMA CHEM
Publication Date
2016-06-01

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Abstract

The invention provides an RGD polypeptide coordination complex of a radioactive nuclide label. According to the structure of the coordination complex, the radioactive nuclide is selected from 64Cu, 68Ga, 111In, 62Cu, 67Cu, 67Ga, 86Y, 89Zr or 18F; the ligand is a ligand compound containing an RGD structure, which is shown in a formula (I). The coordination complex has stronger ligand stability and high target / non-target ratio, and the appetency of the ligand with integrin AlphavBeta3 is stronger. The invention further provides a preparation method of the coordination complex, and an application of the coordination complex in preparing tumor developers.
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Description

technical field

[0001] The invention relates to a radioactive complex, its preparation method and the application of the complex as a tumor imaging agent. Background technique

[0002] According to the current trend of cancer incidence, the incidence of cancer worldwide will increase by 50% in 2020, and the number of new cancer patients worldwide will reach 15 million each year (the World Cancer Report recently published by the World Health Organization (WHO). Early detection and early treatment are the most effective ways to reduce cancer mortality. The implementation of a screening system for bowel cancer, cervical cancer, breast cancer, etc. can reduce the number of cancer deaths worldwide by one-third. Currently in developing countries, 80% of cancer patients are only discovered at the advanced stage of the disease.

[0003] Although the exact mechanism of cancer development is still unclear, if the cancer can be diagnosed at an early stage and treated with surgery, ra...

Claims

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