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Uses of Phlomophores honeysuckle or its extracts

A technology of Lonicera Lonicerae and its extract, which is applied in the direction of drug combination, medical raw materials derived from fungi, metabolic diseases, etc., to promote the secretion of endogenous estrogen, slow down osteoporosis, relieve various symptoms and The effect of signs

Active Publication Date: 2016-12-28
SHENNONGJIA SHAPED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no related reports on the use of Lonicera Lonicerae and the compound hispolon for regulating estrogen and treating diseases such as perimenopausal syndrome

Method used

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  • Uses of Phlomophores honeysuckle or its extracts
  • Uses of Phlomophores honeysuckle or its extracts
  • Uses of Phlomophores honeysuckle or its extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the ethanol extract of Phylopore Lonicerae of embodiment 1

[0035] Phellinus lonicerinus (Phellinus lonicerinus (Bond.) Bond.etsing) was identified by Professor Mao Xiaolan from the Institute of Microbiology, Chinese Academy of Sciences, and was pulverized with a pulverizer. Pass through a 80-mesh sieve to obtain Lonicerae spp. powder; take Lonicera spp. powder, use 8 times 95% ethanol to ultrasonically extract three times, extract for 1 hour each time, concentrate under reduced pressure, and dry to obtain Lonicera spp. Alcoholic extract, the cream yield is 10.7%w / w.

Embodiment 2

[0036] The preparation method of embodiment 2 Phylopore Lonicera water extract

[0037] Phellinus lonicerinus (Phellinus lonicerinus (Bond.) Bond.etsing) was identified by Professor Mao Xiaolan from the Institute of Microbiology, Chinese Academy of Sciences, and was crushed with a pulverizer Pass through a 80-mesh sieve to obtain Lonicerae sp. powder; take Lonicerae sp. powder and extract 3 times with 6 times of water reflux, extract for 1 hour each time, concentrate the extract under reduced pressure, and dry to obtain Lonicera sp. Bacterial water extract, the cream yield is 12.1%w / w.

Embodiment 3

[0038] Embodiment 3 compound hispolon separation and identification

[0039] The ethanol extract prepared in Example 1 was taken, dissolved in methanol, filtered through a 0.45 micron membrane as the sample to be prepared, and prepared by high performance liquid chromatography.

[0040] The preparation conditions are: preparative column: COSMOSIL5C18-MS-II10mmID*250mm; injection volume: 100 microliters; column temperature: 25°C; detection wavelength: 380nm; mobile phase: A: acetonitrile, B: ultrapure water 26% A and 74% of B constant gradient elution. The eluate with peak retention time of 22 min was collected. The eluate was concentrated under reduced pressure and further purified to obtain Hispolone as a yellow powdery solid with a melting point of 137-138°C. The spectral data are as follows (see Figure 1-3 ):

[0041] HRMS: 220.0732.HPLC-MS (RP-18-Phase, APCI+): m / z) 220.97 (100%, [M+H] + ), 219.28 (37%). 1 H NMR (400MHz, CD 3 OD): δ=7.48(1H,d,J=15.6Hz,H-1),7.06(1H,...

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Abstract

The invention discloses an application of phellinus lonicericola or an extract thereof to the preparation of drugs or healthcare products for regulating estrogens and treating perimenopausal syndrome. The invention also provides a new application of a compound hispolon. The phellinus lonicericola and the extract thereof or the compound hispolon can be combined with estrogen receptors to doubly regulate the estrogens and has the function of promoting the secretion of endogenous estrogens when the endogenous estrogens are insufficient; by using the phellinus lonicericola and the extract thereof or the compound hispolon for treatment, various symptoms and signs can be effectively relieved, the function of slowing down the occurrence and the development of the long-term symptoms such as osteoporosis, cardiovascular disease and the like is provided, the quality of life of the perimenopausal syndrome women can be improved and a new way is developed to treat the perimenopausal syndrome.

Description

technical field [0001] The present invention relates to a new application of Pheropora honeysuckle or its extract. Background technique [0002] Estrogen, a female hormone, is mainly produced by the ovaries and placenta, and a small amount of estrogen is also produced by the adrenal cortex and the testes of male animals. After a woman enters puberty, the ovaries begin to secrete estrogen to promote development. Estrogen can also promote the accumulation of subcutaneous fat, plump body, and produce female secondary sexual characteristics; promote the retention of sodium and water in the body, and the deposition of calcium in the bone. If women lack estrogen, there will be perimenopausal syndrome, uterine vaginal atrophy, sagging of pelvic organs, skin dullness and wrinkling, dyslipidemia, increased incidence of coronary heart disease, osteoporosis, senile dementia and other diseases or symptoms . Among them, perimenopausal syndrome is a syndrome mainly caused by autonomic ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61K36/06A61P5/30A61P5/32A61P15/12A61P3/00A61P19/10
Inventor 汪鋆植郝光俊黄年玉罗友成叶红胡芳邓张双张巧银邹坤
Owner SHENNONGJIA SHAPED PHARMA
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