33results about How to "Relieve osteoporosis" patented technology

The invention relates to a biomedical titanium-niobium-based shape memory alloy as well as a preparation method, a processing method and an application method thereof. The alloy comprises the following chemical compositions by weight percent: 28-39% of niobium, 0.35-5.5% of tin, 0.3-5.5% of aluminum, 0.5-5.5% of silicon, 0.2-5.5% of zirconium and the allowance of titanium. The alloy has the advantages of low elasticity modulus, good biocompatibility and mechanics compatibility, no toxic nickel element, good mechanical property and corrosion resisting property, excellent cold working property and low cold-working hardening ratio; the alloy can be used for cold working with large deformation such as cold rolling, cold wire drawing and the like, and the working cost is low. The titanium-niobium-based shape memory alloy is of the ideal and novel biological shape memory alloy material that replaces the TiNi shape memory alloy and can be widely used for an ultra-flexible bracket, an orthodontics dental arch wire and an orthopedics implantation instrument and the like in the fields of the medical treatment, the sports goods and the like.

The invention relates to a health-caring and freshness-retaining bean curd containing squillid heads and squillid shells and a preparation method thereof. Raw materials of the beverage includes, by weight, 55-75% of soybean, 15-25% of cyperus esculentus, 2-5% of a squillid fermentation liquid, 3-6% of glucosamine hydrochloride and 5-9% of caryopteris incana juice. The bean curd is prepared from above raw materials in different processing methods, is high in production rate, is good in elasticity, is strong in toughness, is not liable to break, is fine in texture and is delicious in taste. Not only are problems that the squillid enzymolysis protein liquid is thick in bitter and fishy smell and cannot be used as a food base material solved, but also the bean curd is better in health-caring value and meanwhile is more unique in flavor, is long in preservation time and shelf life and is high in edible safety. The bean curd, when being eaten often, can enhance human body immunity, can improve physiological functions, can reduce glucose and fat, has an anti-microbial effect and an anti-inflammation effect, has an anti-cancer and anti-aging function, can prolong life, can alleviate osteoporosis, can prevent diseases in heart and cerebral vessels and alimentary canals and the like, allows waste materials to be comprehensively reused, and has huge social, ecological, environmental and economic benefits.

The invention relates to the technical field of biological medicine, in particular to dietary supplements capable of enhancing bone density and preventing and improving osteoarthritis. The dietary supplements comprise bovine patella meal processed by superfine grinding, grain such as brown rice, highland barley and oat, traditional Chinese medicine materials such as radix notoginseng, angelica sinensis and rhizoma chuanxiong and compositions such as D-glucosamine hydrochloride, chondroitin sulfate, collagen protein powder, vitamin D, casein peptide phosphate, fructo-oligosaccharide and saussurea involucrata culture. The dietary supplements have the advantages that the dietary supplements are easy to digest and absorb, and capable of supplementing calcium and tonifying the bones, relieving symptoms such as back pain, osteoporosis and arthritis caused by calcium deficiency of the bones, enhancing bone density and preventing and improving osteoarthritis; the fresh bovine patella is subjected to the superfine grinding, the active nutritional components in the bovine patella can be well kept, then the other materials are added to perform decocting and homogenizing, roller drying is then performed to obtain granular or powdered solid, and the dietary supplements can be eaten after being brewed by hot water and are convenient and nutritious.

The invention relates to the technical field of healthcare medicinal food, and in particular relates to an anti-aging nutrition and healthcare product. The anti-aging nutrition and healthcare product comprises Chinese yam extract, ginseng, angelica sinensis, liquorice, radix paeoniae alba, coix seed, poria cocos, cassia twig and oyster shell powder in a certain proportion. The anti-aging nutrition and healthcare product is naturally efficient and non-toxic after being orally taken by a patient, calcium intake can be increased, the caused osteoporosis is relieved, blood vessels are softened, thus the caused cardiovascular and cerebrovascular diseases and stroke are relieved, and the immunity and sexual function are improved; and the typical symptoms which are expressed due to aging are effectively relieved, the aging speed is slowed down, and the senility is relieved. In the formula of the anti-aging nutrition and healthcare product, natural-occurring substances are adopted, are safe and have no side effects; and the anti-aging nutrition and healthcare product has an exact healthcare curative effect of delaying and treating senility.

The invention discloses lactobacillus casei capable of relieving osteoporosis and an application of the lactobacillus casei, which belongs to the technical field of microorganisms and medicines. The invention provides a lactobacillus casei CCFM1127, and the lactobacillus casei CCFM1127 can alleviate osteoporosis, which is specifically embodied in that the bone mineral density level of ovariectomized rats is significantly improved; the bone volume fraction level of ovariectomized rats is obviously improved; the bone trabecula thickness level of ovariectomized rats is obviously improved; the content of IL-1 beta in ovariectomized rat serum is obviously reduced; the content of TNF-alpha in ovariectomized rat serum is obviously reduced; the content of IL-10 in serum of ovariectomized rats is remarkably increased; the content of endotoxin in serum of ovariectomized rats is remarkably reduced, so that the lactobacillus casei CCFM1127 has a huge application prospect in preparation of productsfor preventing and/or treating osteoporosis.

The invention discloses a method for preparing a vegetarian dried meat floss product from cordyceps millitaris fermented glycine max dregs. A glycine max processing byproduct, namely glycine max dregs, is adopted as a raw material, through solid fermentation, flavor blending and frying with cordyceps millitaris, contents of two soy isoflavones, namely daidzein and glycitein, can be remarkably increased, the content of insoluble cellulose can be reduced, and the vegetarian dried meat floss product which is rich in aglycone isoflavones, proteins and edible fungi, is cotton-like and fluffy and has sensitive, physical and chemical and microorganism indexes similar to those of dried meat floss is prepared. The product prepared by using the method is "natural, nutrient and low-grease", and expectation of different customers on nutrient and healthy foods can be met. Solid fermentation used in the method is a traditional and modern biological technology, is efficient and low-carbon, good in applicability and simple to operate, and is free of secondary sterilization; the cordyceps millitaris can be used as an edible fungus, the mycelia of the cordyceps millitaris is rich in nutrition, and the flavor and the drawing feeling of the product can be also improved. By adopting the method, the nutrition and functional value of the vegetarian dried meat floss leisure food can be effectively intensified, and great significances in increasing additional values of the vegetarian dried meat floss product and promoting comprehensive utilization of the glycine max dregs can be achieved.

The invention relates to the field of food, and discloses a small molecule protein peptide pudding as well as a preparation method and application thereof, and the small molecule peptide pudding comprises protein powder, a sweetening agent, fruit powder, a thickening agent, a coagulator, citric acid, milk calcium, edible essence and water. The small molecule protein peptide pudding can supplement high-quality protein and calcium sources which are needed every day and easy to absorb, and helps to relieve age-increasing muscle attenuation, osteoporosis and arthritis. Moreover, the small molecule protein peptide pudding is in a soft gel state, tastes soft, smooth and fine, melts in the mouth, and is suitable for part of old people with dysphagia.

The invention relates to a gelatin small peptide or collagen tripeptide chelated calcium magnesium and a preparation method thereof. The preparation method comprises the following steps: 1, preparinga calcium and magnesium salt mixture from a soluble calcium salt and a soluble magnesium salt according to a molar ratio of calcium ions to magnesium ions is 1:(0.2-0.5), adding gelatin or collagen tripeptide as an ion carrier raw material, adding water according to a weight ratio of the water to the calcium and magnesium salt mixture of 1:(0.5-2), and carrying out full and uniform stirring to obtain a mixed solution; 2, adjusting the pH value of the mixed solution to 4-5.5 by using an organic acid; 3, carrying out an ion chelating reaction at 80-200 DEG C; and 4, adding water to dilute the obtained reaction solution, carrying out dialysis concentration by using a nanofiltration membrane with the molecular weight cutoff being 150-300 Da to make the volume of the obtained concentrate is 1.2-0.8 times the volume of the undiluted solution in order to obtain the gelatin small peptide or collagen tripeptide chelated calcium magnesium. The gelatin small peptide or collagen tripeptide chelated calcium magnesium preparation prepared in the invention does not release inorganic ions with the hydrolysis of macromolecular collagens after entering a body in order to guarantee that the calcium and magnesium absorbed and utilized in small peptide chelate organic forms, so the absorption efficiency and the bioavailability of the calcium and magnesium are improved.

The invention relates to health ice cream containing mantis shrimp heads and mantis shrimp shells and a preparation method thereof. The health ice cream comprises the following raw materials by weight percent: 7-13% of enzymatically hydrolyzed mantis shrimp protein powder, 4-8% of glucosamine hydrochloride, 7-13% of vanilla powder, 6-9% of bifidus sugar, 0.2-0.5% of gleditsia heterophylla gum, 0.8-1.5% of dogwood seed oil and 55-75% of purified water. The ice cream is prepared from the raw materials through various processing means, has sweet taste, faint scent and fine and smooth taste, is tender and smooth in the mouth, not only conduces to solving the problem that with strong bitter taste and fishy smell, the enzymatically hydrolyzed mantis shrimp protein powder can not serve as the base material of food, but also has more unique flavor, better melting resistance and higher edible safety while having preferable nutrition and health values. After being eaten regularly, the ice cream has the effects of clearing away heat and toxic materials, relieving summer heat and quenching thirst, helping produce saliva to slake thirst, reducing the body weight and benefiting qi and enhancing the human immunities and can achieve the health effects of building bodies and prolonging lives. The ice cream comprehensively utilizes the waste materials and has huge social, ecological, environmental and economic benefits.

The invention relates to the technical field of food processing and discloses a spicy bean curd ice cream which comprises an ice cream shell made of white chocolate and stuffing filling the ice creamshell. The ice cream shell comprises, by weight, the following components: 190-210 parts of white chocolate, 0.6-0.8 part of sesame oil and 0.08-0.11 part of salt. The invention also discloses a making method of the ice cream. The making method comprises the steps of foaming the stuffing, melting the white chocolate, refrigerating a mold, filling the white chocolate mold, refrigerating for forming, injecting the stuffing, freezing, sealing the bottom and the like. The bean curd-shaped ice cream can be provided for merchants, and the creative value of the ice cream is increased by utilizing thelove of people for the ice cream and the bean curd at the same time. The ice cream prepared by the making method does not contain additives and can also be sold instantly.

The invention relates to application of allantoin or pharmaceutically acceptable salts, esters or prodrugs thereof in relieving side effects of glucocorticoid. A compound shown in the formula I or pharmaceutically acceptable salts, esters or prodrugs thereof can be used for preparing drugs for relieving side effects of glucocorticoid. The compound disclosed by the invention can relieve side effects of glucocorticoid drugs, can remarkably relieve osteogenic differentiation inhibition caused by glucocorticoid, promotes osteogenic differentiation of cells induced by glucocorticoid, and has important clinical significance for developing new drugs.

The invention discloses healthcare tablets capable of increasing the bone mineral density and a preparation method and application thereof. The healthcare tablets are prepared from, by weight, 18-28 parts of folium sauropi, 3-10 parts of rhizoma valerianae jatamansi and 20-32 parts of pericarpium citri reticulatae. The preparation method comprises the steps that folium sauropi and rhizoma valerianae jatamansi are dried, smashed, mixed and delivered into an extraction kettle for subcritical extraction, and extraction liquid is prepared; pericarpium citri reticulatae is smashed and added with deionized water, and stirring under heating is performed to prepare pericarpium citri reticulatae mixed liquid; the pericarpium citri reticulatae mixed liquid and the extraction liquid are mixed and subjected to ultrasonic treatment, low-temperature decompress concentration, drying and pressing and tablet forming, and then the healthcare tablets are obtained. According to the healthcare tablets, osteoporosis and a fracture-prone symptom which are caused by bone mineral density decreasing are improved and relieved by increasing the bone mineral density under the combined action of all the raw materials; health food safety toxicology evaluation tests prove that the healthcare tablets are safe and nontoxic and can be taken for a long term; animal function tests prove that the healthcare tablets have the function of increasing the bone mineral density and are stable and controllable in quality and reasonable in dosage form.

The invention discloses a fully humanized monoclonal single-domain antibody for resisting human PTH1R and an application of the fully humanized monoclonal single-domain antibody. The amino acid sequence of the antibody is shown as SEQ ID NO: 2. According to the invention, aiming at wild and mutant human PTH1R ECD proteins, antibody screening is carried out by using a phage display technology, and the anti-human PTH1R blocking type single-domain antibody with a blocking effect is screened and obtained through methods such as ELISA, FACS and the like. The antibody can be combined with human PTH1R, can block the interaction between PTH and PTH1R, and has a potential application value in human body dysfunction mediated by PTH-PTH1R, such as chronic kidney disease secondary hyperparathyroidism.

The invention belongs to the technical field of medicines, particularly relates to application of alpinetin in preparation of medicines for preventing and treating osteoporosis, and provides new application of the alpinetin, namely application of the alpinetin in prevention and treatment of osteoporosis. The alpinia japonica can activate PKA/mTOR autophagy signals so as to up-regulate the expression levels of Runx2, OCN and OPN proteins in the osteogenic differentiation process of mesenchymal stem cells (MSCs), and finally enhance the osteogenic differentiation of the MSCs, so that the osteoporosis is effectively relieved, and the alpinia japonica can be applied to the development of medicines for efficiently preventing and treating the osteoporosis. The invention not only provides a new application of the alpinetin, but also provides a new therapeutic drug and a new therapeutic approach for the treatment of osteoporosis.

The present invention provides a health-care soft capsule for improving health of menopausal women. The soft capsule comprises a capsule shell and a content wrapped in the capsule shell. The content in the capsule shell comprises libanotis buchtormensis, cynanchum bungei fruits, hop, wine-prepared glossy privet fruits, Turmeric root-tuber, Chinese angelica, thunberg fritillary bulbs, spina date seeds and ingredients; the capsule shell comprises gelatin, glycerin, soybean oil and water; and the ingredients are soybean isoflavones, collagen, multivitamins, amino acids, beeswax and lecithin. At the same time, the present invention also provides a preparation method. The method is simple and conducts conventional water extraction. Each raw material complements each other and works together. The prepared soft capsule can effectively alleviate symptoms of facial flushing, armpit sweating, body numbness, sleep disorder, nervousness, depression, vertigo, fatigue, muscle and joint pains, etc. of the menopausal women, at the same time can increase bone density, and effectively alleviates a problem of osteoporosis in the menopausal women.

The invention belongs to the technical field of biological medicines, and particularly discloses a recombinant plasmid for inhibiting SOST gene expression and a bone-targeted recombinant adeno-associated virus and application of the bone-targeted recombinant adeno-associated virus. The bone-targeted recombinant adeno-associated virus, which can target bone cells and reduce the expression and the secretion of bone cell Sclerostin (Sost), and has anti-osteoporosis effect, is constructed, and has the administration route including intramuscular injection and intravenous infusion, is convenient to use, and provides the powerful evidence for the application in the treatment or prevention of osteoporosis.