Celecoxib solid dispersion and preparation method thereof
A technology of solid dispersion and celecoxib, which is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problem of slow dissolution of celecoxib raw materials and polyethylene glycol. High viscosity, difficult to dissolve evenly, etc., to achieve the effect of easy operation, high drug loading, and avoiding the crushing process
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[0028] Example 1
[0029] formula:
[0030]
[0031] Celecoxib raw materials are prepared according to Chinese patent application CN1141630A.
[0032] Preparation:
[0033] Weigh the raw and auxiliary materials according to the formula, and completely dissolve them in ten times the amount of methanol, remove the solvent by rotary evaporation, and then place it in a vacuum drying oven to dry under reduced pressure.
Example Embodiment
[0034] Example 2
[0035] formula:
[0036]
[0037] Preparation:
[0038] Weigh the raw and auxiliary materials according to the formula, and completely dissolve them in 20 times the amount of ethanol, remove the solvent by rotary evaporation, and place it in a vacuum drying oven to dry under reduced pressure.
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[0039] Example 3
[0040] formula:
[0041]
[0042] Preparation:
[0043] Weigh the raw and auxiliary materials according to the formula, and completely dissolve them in five times the amount of acetone, remove the solvent by rotary evaporation, and place it in a vacuum drying oven to dry under reduced pressure.
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