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A kind of medical reinforcing fiber and its preparation method

A technology of reinforcing fibers and fibers, which is applied in the field of preparation of medical degradable reinforcing fibers, can solve the problems of easy agglomeration, small aspect ratio of HA fibers, poor mechanical strength, etc., and achieves simple operation, high mechanical strength, and wide application prospects. Effect

Active Publication Date: 2016-01-06
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main technical problem solved by the present invention is to provide a medical reinforcing fiber with a high aspect ratio and its preparation method, thereby solving the problem that the HA fiber prepared by the existing method has a small aspect ratio, poor mechanical strength, poor dispersion of the fiber and Easy to agglomerate, unable to obtain single crystal fiber and other problems

Method used

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  • A kind of medical reinforcing fiber and its preparation method
  • A kind of medical reinforcing fiber and its preparation method
  • A kind of medical reinforcing fiber and its preparation method

Examples

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preparation example Construction

[0030] The preparation method of nanometer or micron HA fiber of the present invention mainly comprises the following steps:

[0031] (1) Prepare a certain concentration of dilute nitric acid solution, add a certain amount of calcium salt and phosphate, and prepare a solution containing a certain concentration of calcium ions and phosphate ions. The molar concentration ratio of fixed calcium ions and phosphate ions is 1:1. At the same time, one or more salts of trace elements or other doping elements required by the human body can be optionally added or not added;

[0032] (2) Add a certain amount of pH regulator subsequently, and control it within a certain concentration range;

[0033] (3) Then add a certain amount of surfactant, and stir for several minutes to make it evenly mixed, and the surfactant is controlled within a certain concentration range;

[0034] (4) Pour the solution into the autoclave so that the solution accounts for 70% to 80% of the total volume of the a...

example 1

[0050] The concrete steps that the present invention prepares HA nanofiber are as follows:

[0051] (1) The preparation concentration is 0.08mmolL -1 Nitric acid solution, and to it, calcium nitrate calcium salt and ammonium phosphate are added and dissolved, and the calcium ion concentration and the phosphate ion concentration are prepared to be 40mmolL -1 solution, the molar concentration ratio of fixed calcium and phosphorus is 1:1. Then add strontium hydrogen phosphate and dissolve, the concentration is 0.001~0.1mmolL -1 .

[0052] (2) Then add the pH regulator dimethylacetamide, continue stirring to dissolve it, and the concentration of dimethylacetamide after it is completely dissolved is 0.6molL -1 .

[0053] (3) Then add surfactant triethanolamine lauryl sulfate, and stir for a few minutes to make it mix evenly, the concentration of surfactant is 10mmolL -1 .

[0054] (4) Pour the solution into the autoclave so that the solution accounts for 70% to 80% of the tot...

example 2

[0059] The concrete steps that the present invention prepares HA nanofiber are as follows:

[0060] (1) The preparation concentration is 0.08mmolL -1 Nitric acid solution, and to it, calcium nitrate calcium salt and ammonium phosphate are added and dissolved, and the calcium ion concentration and the phosphate ion concentration are prepared to be 45mmolL -1 solution, the molar concentration ratio of fixed calcium and phosphorus is 1:1. Then add ammonium carbonate and dissolve, its concentration is 1~10mmolL -1 .

[0061] (2) Add pH adjuster dimethylacetamide subsequently, continue to stir to make it dissolve, the concentration after the complete dissolution of dimethylacetamide is 1molL -1 .

[0062] (3) Then add surfactant triethanolamine lauryl sulfate, and stir for a few minutes to make it mix evenly, the concentration of surfactant is 10mmolL -1 .

[0063] (4) Pour the solution into the autoclave so that the solution accounts for 70% to 80% of the total volume of the...

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Abstract

The invention relates to medical reinforced fiber, which is a nano-level or micro-level HA (Hydroxyapatite) fiber monocrystal, wherein the mol ratio of Ca to P in nano-level or micro-level HA fiber is 1.50 to 1.90. The preparation method of the medical reinforced fiber comprises the following steps of configuring a certain-concentration dilute nitric acid solution and adding a certain amount of calcium salt and phosphate for the formation of a solution which contains a certain concentration of calcium ions and phosphate radicals; subsequently adding a certain quantity of pH regulators and controlling the pH regulator within a certain concentration range; then adding a certain quantity of surfactants, evenly stirring and mixing the surfactant and controlling the surfactant within a certain concentration range; pouring the solution into a high-pressure autoclave, reacting at a certain temperature for a period of time, and cooling to the room temperature; and finally, centrifuging the solution in the high-pressure autoclave and drying resultant sediments in the high-pressure autoclave for the formation of the nano-level or micro-level HA fiber. The length-diameter ratio of the nano-level HA fiber provided by the invention reaches up to 1000; and meanwhile, the dispersibility is good and the reinforcement effect is ideal.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a method for preparing medically degradable reinforcing fibers. Background technique [0002] Hydroxyapatite (HA for short) is the most important inorganic salt component in human bones, which is degradable and has good osteocompatibility and inductivity. At present, HA has been widely used clinically as bone repair material, artificial joint coating and other metal implant coating. Since the 1990s, in order to further expand the scope of clinical use of HA, people began to study the synthesis technology of HA fibers, trying to use HA fibers to replace some inert fibers in clinical applications. At present, there are some methods for the preparation of HA fibers: the dissolution-reprecipitation method of calcium dihydrogen phosphate under hydrothermal conditions, the uniform precipitation method, and the high-temperature solid-phase synthesis method. However, since the struc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32B82Y40/00
Inventor 佘振定谭荣伟
Owner SHENZHEN LANDO BIOMATERIALS