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Fully biodegradable polyester copolymer and preparation method and application thereof

A technology for degrading polyesters and copolymers, applied in medical science, surgery, etc., can solve problems such as high crystallinity and poor mechanical properties, and achieve the effects of reduced crystallinity, improved toughness, and good biocompatibility

Inactive Publication Date: 2013-04-10
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to provide a fully biodegradable polyester copolymer material and its preparation method and application in view of the defects of poor mechanical properties and high crystallinity in existing fully biodegradable vascular stent materials

Method used

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  • Fully biodegradable polyester copolymer and preparation method and application thereof
  • Fully biodegradable polyester copolymer and preparation method and application thereof
  • Fully biodegradable polyester copolymer and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Add 27.785g of L-lactide, 1.036g of trimethylene carbonate, 1.178g of glycolide, and 30.1mg of stannous octoate into the polymerization tube. The optical purity of L-lactide is 98.5%ee. Inflate with nitrogen and catch up with oxygen, vacuumize, repeat three times. Then continue vacuuming, and control the vacuum degree in the polymerization tube to be not higher than 1Pa. Put the melted polymer tube at 130 o In a constant temperature oven at C, react for 72 hours to obtain a completely biodegradable PLLA-TMC-GA terpolymer. The schematic diagram of the reaction process is shown in figure 1 shown. The resulting product was purified, and its number-average molecular weight was determined to be 2.36×10 5 g / mol, the dispersion coefficient is 2.19.

[0040] (2) figure 2 IR spectrum of PLLA-TMC-GA terpolymer. 2998, 2947, 1459 and 1387 cm in the picture -1 The absorption peak at is attributed to the -CH of the LA segment 3 , 1423cm -1 -CH attributable to the GA s...

Embodiment 2

[0045] 26.702 g of L-lactide, 2.102 g of trimethylene carbonate, 1.196 g of glycolide, and 30.1 mg of stannous octoate were added to the polymerization tube. The optical purity of L-lactide is 98.5%ee. The synthesis process is as described in step (1) in Example 1. The resulting product was purified, and its number-average molecular weight was determined to be 2.37×10 5 g / mol, the dispersion coefficient is 2.31. The molar ratio of LLA, TMC, and GA three monomers is 90 / 10 / 5. The glass transition temperature is 54.0 o C, No crystallization behavior. The tensile strength is 49.6MPa, the Young's modulus is 1742MPa, and the elongation is 304%.

Embodiment 3

[0047] 25.588 g of L-lactide, 3.199 g of trimethylene carbonate, 1.213 g of glycolide, and 30.1 mg of stannous octoate were added to the polymerization tube. The optical purity of L-lactide is 98.5%ee. The synthesis process is as described in step (1) in Example 1. The resulting product was purified, and its number-average molecular weight was determined to be 2.09×10 5 g / mol, the dispersion coefficient is 2.39. The molar ratio of LLA, TMC, GA three monomers is 85 / 15 / 5. The glass transition temperature is 50.9 o C, No crystallization behavior. The tensile strength is 34.3MPa, the Young's modulus is 1199MPa, and the elongation is 342%.

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Abstract

The invention belongs to the technical field of high polymer material, and particularly relates to a fully biodegradable polyester copolymer and a preparation method and application thereof. The polyester copolymer is a PLLA-TMC-GA terpolymer, and is formed through ring opening polymerization of three kinds of monomers, namely l-lactide (LLA), trimethylene carbonate (TMC) and glycolide (GA), under the effect of catalyst under a certain condition. The average molecular weight of the polyester copolymer is higher than 1.42*10<5> g / mol, the tensile strength of the polyester copolymer is 34.3 to 52.3 MPa, the ductility of the polyester copolymer is 249 to 402 percent, and the polyester copolymer has an amorphous state and a rather low degree of crystallinity. The copolymer prepared according to the preparation method is greatly improved in toughness and keeps a high tensile strength, so that the copolymer prepared according to the preparation method has good mechanical property, good biocompatibility and controllable degradation velocity, has a broad application prospect in the field of biomedicine, and is particularly suitable for preparing completely safe biodegradable intravascular stents.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a completely biodegradable polyester copolymer and its preparation method and application. Background technique [0002] Poly-L-lactic acid (PLLA) is a biodegradable polyester with excellent biocompatibility, which is approved by the US Food and Drug Administration (FDA) Materials such as balls and implants. As a biodegradable polymer material, it can overcome the shortcomings of traditional non-degradable materials that cannot be absorbed by the human body and must be removed through secondary surgery. At the same time, PLLA has the general characteristics of traditional engineering polyester materials, such as high rigidity and strength, easy processing and molding, and is suitable for various process conditions. [0003] However, PLLA is a brittle material at room temperature, and its elongation is generally not higher than 10%. When used as a vascular...

Claims

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Application Information

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IPC IPC(8): C08G63/64A61L31/06
Inventor 范仲勇董建廷廖岚石莉李速明
Owner FUDAN UNIV
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