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Osmotic slow-release material in ethyl acrylate-methyl methacrylate copolymer aqueous dispersion and preparation method thereof

A technology of methyl methacrylate and ethyl acrylate, which is applied in the field of medium osmotic slow-release materials and their preparation, can solve the problems of explosiveness, three wastes, and high cost, and achieves the effects of easy film formation, good plasticity and stable placement.

Inactive Publication Date: 2013-04-17
悦康药业集团安徽天然制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of coating with polyacrylic resin No. Ⅱ or Ⅲ products are: high cost, explosive, and three wastes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A osmotic slow-release material in an ethyl acrylate-methyl methacrylate copolymer aqueous dispersion, which is made of the following raw materials in the weight ratio: ethyl acrylate: 105, methyl methacrylate: 55, purified Water: 390, potassium persulfate or ammonium persulfate 0.9, alkylphenol polyoxyethylene ether (OP-10): 3.

[0018] Its preparation method steps are as follows:

[0019] (1) Put the raw materials ethyl acrylate, methyl methacrylate, purified water, alkylphenol polyoxyethylene ether (OP-10) into the reaction tank according to the weight ratio;

[0020] (2) Stir and heat to 70°C-80°C, put the potassium persulfate or ammonium persulfate solution dissolved in purified water into the high level tank;

[0021] (3) Add dropwise to the reaction tank under stirring, and keep the temperature of the reaction tank at 70°C-80°C during the dropping process;

[0022] (4) After dropping, keep the temperature at 70°C-80°C for 2-3 hours and react for 2-3 hours; rais...

Embodiment 2

[0034] A kind of ethyl acrylate-methyl methacrylate copolymer water dispersion osmotic sustained-release material, which is made of the following raw materials in weight ratio: ethyl acrylate: 95, methyl methacrylate: 55, purified Water: 350, potassium persulfate or ammonium persulfate 0.9, alkylphenol polyoxyethylene ether (OP-10): 2.25.

[0035] Its preparation method steps are as follows:

[0036] (1) Put the raw materials ethyl acrylate, methyl methacrylate, purified water, alkylphenol polyoxyethylene ether (OP-10) into the reaction tank according to the weight ratio;

[0037] (2) Stir and heat to 80°C, put the potassium persulfate or ammonium persulfate solution dissolved in purified water into the high level tank;

[0038] (3) Add dropwise to the reaction tank under stirring, and keep the temperature of the reaction tank at 70°C-80°C during the dropping process;

[0039] (4) After dropping, keep the temperature at 80°C for 2-3 hours and react; raise the temperature to ...

Embodiment 3

[0041] A osmotic slow-release material in an ethyl acrylate-methyl methacrylate copolymer aqueous dispersion, which is made of the following raw materials in the weight ratio: ethyl acrylate: 105, methyl methacrylate: 55, purified Water: 390, potassium persulfate or ammonium persulfate 0.9, alkylphenol polyoxyethylene ether (OP-10): 3.

[0042] Its preparation method steps are as follows:

[0043] (1) Put the raw materials ethyl acrylate, methyl methacrylate, purified water, alkylphenol polyoxyethylene ether (OP-10) into the reaction tank according to the weight ratio;

[0044] (2) Stir and heat to 70°C, put the potassium persulfate or ammonium persulfate solution dissolved in purified water into the high level tank;

[0045] (3) Add dropwise to the reaction tank under stirring, and keep the temperature of the reaction tank at 70°C during the dropping process;

[0046] (4) After dripping, keep the temperature at 80°C for 2 hours, then raise the temperature to 90°C, continue ...

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Abstract

The invention discloses an osmotic slow-release material in an ethyl acrylate-methyl methacrylate copolymer aqueous dispersion. The osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion comprises the following raw materials in part by weight: 90-110 parts of ethyl acrylate, 45-65 parts of methyl methacrylate, 0.2-1.2 parts of potassium persulfate or ammonium persulfate, 1-5 parts of alkylphenol ethoxylate (OP-10) and 320-410 parts of purified water. Compared with the existing coating materials at home, slow-release tablets prepared from the osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion has the advantages of good plasticity, easiness in film formation, no addition of a plasticizer, better slow-release effect and the like; polymerized neutral copolymer dispersed particles contained in a latex solution provided by the invention have a particle diameter range of 10-1000 nm; and due to thermal convection and Brownian motion of the particles, at the room temperature, the osmotic slow-release material in the ethyl acrylate-methyl methacrylate copolymer aqueous dispersion is stable to store, non-toxic and harmless.

Description

[0001] technical field [0002] The present invention mainly relates to a medium osmotic slow-release material and a preparation method thereof, in particular to a medium osmotic slow-release material in aqueous dispersion of ethyl acrylate-methyl methacrylate copolymer and a preparation method thereof. Background technique [0003] At present, the drug sustained-release coating materials used in China include polyacrylic acid resin emulsion (gastric disintegration type), polyacrylic resin No. Ⅱ or Ⅲ and HPMC compound. Gastric disintegration resin is a polyacrylic resin latex polymerized by butyl acrylate and methyl methacrylate. Because of its poor stability, it is difficult to ensure the quality of the coating material. In addition, the pH of the product is 1-3. Thereby the sustained-release pharmaceutical preparation that is packaged is difficult to reach the relevant regulation of Chinese Pharmacopoeia, so market nearly 30 years, the market usage amount is seldom. At p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K9/32C08F220/18C08F220/14C08F2/30
Inventor 李玉生张涛
Owner 悦康药业集团安徽天然制药有限公司
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