Synthesis process of 2,6-diacetyl pyridine

Abstract

A synthesis process of 2,6-diacetyl pyridine relates to a synthesis process of organic intermediates, especially to the synthesis process of the 2,6-diacetyl pyridine. The invention provides the synthesis process of the 2,6-diacetyl pyridine and the synthesis process is low in time-consuming, simple to operate and high in yield. The invention adopts the following technical scheme that process steps comprise synthesis of 2,6-pyridine diformylic ethyl ester, and synthesis of the 2,6-diacetyl pyridine.

Description

Technical field: [0001] The present invention relates to a kind of synthetic technique of organic intermediate, more specifically, relate to the synthetic technique of 2,6-diacetylpyridine. Background technique: [0002] 2,6-Diacetylpyridine (DAP for short) is a very important organic intermediate, which forms a Schiffer base macrocyclic ligand with amine compounds, and is widely used in medicine, asymmetric catalytic reactions, etc. DAP is also an essential raw material for pyridine bis-imine iron-based complexes, the third generation of high-activity late-transition metal olefin polymerization catalysts after Ziegler-Natta catalysts and metallocene catalysts, and its usage is increasing day by day. [0003] At this stage, there are mainly two synthesis methods of DAP: [0004] One is under the action of sodium ethoxide, 2,6-pyridine dicarboxylate and ethyl acetate undergo Claisen condensation and hydrolysis to obtain after decarboxylation. Although the method has a high y...

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Problems solved by technology

[0004] One is under the action of sodium ethoxide, 2,6-pyridine dicarboxylate and ethyl acetate undergo Claisen condensation and hydrolysis to obtain after decarboxylation. Although the method has a high yield, the raw materials ethyl acetate, solvent and alkali reagent ethanol Sodium must be pre-treated, the operation is cumbersome and time-consuming

[0005] The second is that under the catalysis of cuprous iodide, 2,6-pyridinedicarboxylic acid reacts with excess methyllithium to obtain the product. This method has harsh process conditions and requires the use of relatively expensive methyllithium reagents

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