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Meloxicam pharmaceutical composition and preparation method thereof

A technology for meloxicam and composition, which is applied in the field of meloxicam pharmaceutical composition and its preparation, can solve the problems affecting the application of meloxicam, poor stability and the like, and achieves prescription and process optimization, resistance to Strong abrasiveness and beautiful appearance

Active Publication Date: 2013-04-24
KANGYA OF NINGXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the stability of the existing drugs with meloxicam as the main active ingredient is not good, which affects the application of drugs with meloxicam as the main active ingredient. The stability of active ingredients in drugs has become an important research topic

Method used

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  • Meloxicam pharmaceutical composition and preparation method thereof
  • Meloxicam pharmaceutical composition and preparation method thereof
  • Meloxicam pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Raw material formula:

[0019]

[0020]

[0021] Preparation:

[0022] 1) Dissolve poloxamer in 5 times of ethanol to make a poloxamer solution; add pregelatinized starch to purified water to make a pregelatinized starch solution with a concentration of 8%; add the pregelatinized starch solution to Poloxamer solution, and add purified water to make a mixed solution A with a mass concentration of 10%.

[0023] 2) Pass the meloxicam through a 100-mesh sieve, pass the lactose through a 80-mesh sieve, mix the sieved meloxicam and lactose, add hydroxypropyl cellulose and mix to form a mixture B;

[0024] 3) Add the mixed solution A to the mixture B, stir evenly, and make particles C with a particle size of 24 mesh;

[0025] 4) Dry the granules C at 80°C for 15 minutes, add sodium starch glycolate and magnesium stearate after drying, mix them, and press at a pressure of 10KN for 1 hour to form tablets.

Embodiment 2

[0027] Raw material formula:

[0028]

[0029] Preparation:

[0030] 1) Dissolve poloxamer in 8 times of ethanol to make poloxamer solution; add pregelatinized starch to purified water to make pregelatinized starch solution with a concentration of 15%; add pregelatinized starch solution to Poloxamer solution, and add purified water to make a mixed solution A with a mass concentration of 12%.

[0031] 2) Pass the meloxicam through a 100-mesh sieve, pass the lactose through a 80-mesh sieve, mix the sieved meloxicam and lactose, add hydroxypropyl cellulose and mix to form a mixture B;

[0032] 3) Add the mixed solution A to the mixture B, stir evenly, and make particles C with a particle size of 24 mesh;

[0033] 4) Dry the granule C at 80°C for 15 minutes, add sodium starch glycolate and magnesium stearate after drying, and press it under a pressure of 10KN for 1 hour to form a tablet.

Embodiment 3

[0035] Raw material formula:

[0036]

[0037] Preparation method: with embodiment one.

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Abstract

The invention discloses a meloxicam pharmaceutical composition and a preparation method thereof. The meloxicam pharmaceutical composition comprises the following ingredients in percentage by weight: 2-10% of effective component, namely, meloxicam, 70-80% of filling agent, 7-11% of disintegrating agent, 2-5% of adhesive, 0.2-0.8% of solubilizer, 0.2-5% of lubricant and a moderate amount of solvent. Due to the reasonable auxiliary material selection and ratio distribution of the meloxicam pharmaceutical composition disclosed by the invention, the in-vitro dissolution of a meloxicam tablet prepared from the meloxicam pharmaceutical composition is significantly improved; and meanwhile, by using a preparation method of wet granulation, the tablet prepared from the meloxicam pharmaceutical composition disclosed by the invention is attractive in appearance, good in granule flowability, strong in abrasion resistance and good in compression shaping ability; due to the optimization of the preparation method and the process, the stability of the medicine in the production process is ensured, and the product quality is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a meloxicam pharmaceutical composition and a preparation method thereof. Background technique [0002] Meloxicam is a new generation of non-steroidal anti-inflammatory drugs developed by BOEDIRINGER INGELHEIM of Germany. It was launched in South Africa and the United Kingdom in 1996. Its dosage forms include tablets and suppositories. The greatest feature of meloxicam is its selective inhibition of type II cyclooxygenase (COX-2) inhibitors. The product has significant and lasting anti-inflammatory effects and certain antipyretic and analgesic effects. Meloxicam still has good pharmacokinetic properties, such as fast absorption, high blood concentration, high bioavailability, and high plasma protein binding rate, especially because it can selectively enter the inflamed site, so it has a strong anti-inflammatory effect And lasting. [0003] However, the stability of the existing drugs wi...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61K9/20A61P29/00A61P19/02
Inventor 杨亚军姚婷婷
Owner KANGYA OF NINGXIA PHARMA
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