Aliphatic polyester/calcium carbonate composite material and its preparation method

Abstract

The invention discloses an aliphatic polyester / calcium carbonate composite material. The composite material is obtained through in-situ ring-opening polymerization of 0.3-10 parts of calcium carbonate and 100 parts of a lactone monomer, wherein calcium carbonate is / is not subjected to surface modification treatment, and the morphology of the calcium carbonate has a dandelion shape formed through the self-assembling of sheet-shaped, spherical, silkworm cocoon-shaped, rhombohedral, rod-shaped, hollow bamboo shoot-shaped, dead tree trunk-shaped, bunchy, cactus-shaped, petal-shaped, cockscomb-shaped or nanometer rods, or has a hemispheric shape self-assembled through nanometer rods. The invention also discloses a preparation method of the composite material. Calcium carbonate utilized in the invention has abundant morphologies, and has a large contact area with a matrix, so the organic and inorganic endophilicity in the composite material is increased, and simultaneously calcium carbonate can be uniformly dispersed in the matrix, thereby the toughness of the aliphatic polyester matrix is well enhanced, and the composite mateiral can be well applied in the biomedical fields of bone restoration, bone fixation and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer / inorganic particle composite material and its preparation, and in particular relates to an aliphatic polyester / calcium carbonate composite material and a preparation method thereof. Background technique [0002] Aliphatic polyesters such as polylactic acid (PLA), polyε-caprolactone (PCL), and polydioxanone (PPDO) have good biocompatibility, biodegradability, and bioabsorbability. The field of biomedical materials is developing rapidly. It is not only used as surgical sutures, orthopedic repair materials, skin and corneal repair, etc., but also has great application potential in the fields of orthopedic fixation materials, vascular stents, and drug carriers. It has been widely concerned by researchers from all over the world. [0003] An ideal bone repair material should be a material that can promote bone healing through the triple mechanism of bone formation, osteoconduction, and osteoinduction,...

AI Technical Summary

Problems solved by technology

Although aliphatic polyester has good biodegradability, biocompatibility and formability and can be used as a framework material for bone tissue engineering alone, it has many disadvantages: (1) low mechanical strength; (2) hydrophilic Poor cell adsorption ability; (3) Aseptic inflammatory reaction will occur after implantation in vivo (Du, J.M.; Liu, J. M.; Li, Z. M.; Han, Z. H.; Huang, B. X.; Zhang, Y. Microp . Mesop. Mater. 2005, 145-149.)

Although this hydroxylated MgO-initiated polymerization resulted in composites with better properties, the addition of MgO significantly accelerated the degradation rate of the aliphatic polyester (Murariu, M.; Doumbia, A.; Bonnaud, L. , et al. Biomacromolecules 2011, 12, 1762 – 1771), and the acidic degradation products produced during the degradation process can easily cause aseptic inflammation at the implantation site

At the same time, the biocompatibility, toxicity and osteoinductivity of MgO have not been reported in the literature at home and abroad, and whether it can be used as a bone tissue repair material remains to be further confirmed.

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