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Detection method for residual quantity of multiple preservatives in cosmetics

A detection method and cosmetic technology, applied in the fields of analytical chemistry and food safety, can solve the problem that the preservative determination method cannot meet the requirements of national health supervision, and achieve the effect of satisfying the precision and the recovery rate.

Inactive Publication Date: 2013-04-24
林维宣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current determination method of preservatives in cosmetics is still far from meeting the requirements of national health supervision

Method used

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  • Detection method for residual quantity of multiple preservatives in cosmetics
  • Detection method for residual quantity of multiple preservatives in cosmetics
  • Detection method for residual quantity of multiple preservatives in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Detection method of multiple preservative residues in cream cosmetics

[0047] 1. Sample extraction and purification:

[0048] Weigh 0.2 g sample (accurate to 0.001 g) into a 50 mL Erlenmeyer flask, add 10 mL tetrahydrofuran, sonicate for 10 min, filter through a 0.45 μm membrane, and inject the sample.

[0049] 2. Determination by gas chromatography-mass spectrometer

[0050] ①Qualitative determination: Measure the sample solution and standard solution respectively according to gas chromatography / mass spectrometry conditions. If the GC-MS data of the sample meets the following restrictions, it can be qualitatively determined as a certain preservative residue:

[0051]A. The substance to be tested in the sample has the same retention time as the standard substance, and the deviation is within ±2.5%;

[0052] B. The signal-to-noise ratio of the monitored ions should be ≥3;

[0053] C. There are all selected monitoring ions in the mass spectrum of the peak af...

Embodiment 2

[0090] Example 2 Detection method of multiple preservative residues in milky cosmetics

[0091] 1. Sample extraction and purification: same as Example 1.

[0092] 2. Measurement by gas chromatography-mass spectrometer: the same as in Example 1.

[0093] 3. Linear relationship: with embodiment 1.

[0094] 4. The lower limit of detection: the same as in Example 1.

[0095] 5. Recovery rate and precision: Accurately weigh the milky sample without preservatives, add 3 different content levels of 21 kinds of preservative mixed standard solutions, and carry out 6 parallel samples for each concentration, and carry out according to the above chromatographic conditions analyze. The calculation results of recovery rate and coefficient of variation are shown in Table 5.

[0096] Table 5 Recovery rate (%) and relative standard deviation (%) of 21 kinds of preservatives in cosmetics in milk samples

[0097]

[0098] From the results in Table 5, it can be seen that the average recov...

Embodiment 3

[0099] Example 3 Detection method of multiple preservative residues in water-like cosmetics

[0100] 1. Sample extraction and purification: same as Example 1.

[0101] 2. Measurement by gas chromatography-mass spectrometer: the same as in Example 1.

[0102] 3. Linear relationship: with embodiment 1.

[0103] 4. The lower limit of detection: the same as in Example 1.

[0104] 5. Recovery rate and precision: Accurately weigh the water sample without preservatives, add 21 kinds of preservatives mixed standard solutions with 3 different content levels, and carry out 6 parallel samples for each concentration, according to the above chromatographic conditions for analysis. The calculation results of recovery rate and coefficient of variation are shown in Table 6.

[0105] Table 6 Recovery rate (%) and relative standard deviation (%) of 21 kinds of preservatives in cosmetics in aqueous samples

[0106]

[0107] From the results in Table 6, it can be seen that the average rec...

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Abstract

The invention relates to the field of analytical chemistry and food safety, in particular to a detection method for residual quantity of multiple preservatives in cosmetics. According to a gas chromatography-mass-spectrography detection method which can detect the residual quantity of multiple preservatives in cosmetics simultaneously, sample extraction and purification are respectively processed according to differences of sample shapes and properties, and then a gas chromatography-mass spectrometer is adopted to carry out qualitative determination and quantitative assay. The detection method achieves simultaneous detection of 21 preservatives, and has the advantages of being simple and convenient, fast, sensitive, and the like. The detection minimum, the recovery rate and the degree of precision of the method all meet relevant demands for preservative detection in the cosmetics at home and abroad, so the method is suitable for detection and monitoring of the preservatives in the cosmetics.

Description

technical field [0001] The invention relates to the fields of analytical chemistry and food safety, in particular to a method for detecting residual preservatives in cosmetics. Background technique [0002] Since various nutrients are added to cosmetics, and these nutrients are the medium for the proliferation and reproduction of microorganisms, during the production, use and storage of cosmetics, they may be contaminated by bacteria, which may cause the product to produce odor or change the appearance. In order to inhibit bacteria For growth and reproduction, a certain amount of preservatives must be added to the product. [0003] There are many kinds of preservatives. According to the publications of US FDA and CTFA, there are about 110-120 kinds of chemical preservatives allowed in cosmetics, including 40 kinds of compounds, 20-30 kinds of derivatives, and about 50 kinds of compound preservatives. Although preservatives can inhibit the growth of microorganisms in the cos...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 林维宣徐伟张宁赵雪蓉金红利
Owner 林维宣
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