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Application of N-acetyl-cysteine amide as feed additive

A cysteine ​​amide and feed additive technology, applied in the application, animal feed, animal feed and other directions, can solve the problem of not finding the technical solution of N-acetylcysteine ​​amide, so as to enhance the disease resistance of animals, promote the The effect of producing and improving antioxidant capacity

Inactive Publication Date: 2013-05-01
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no technical solution for the application of N-acetylcysteine ​​amide as an animal feed additive

Method used

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  • Application of N-acetyl-cysteine amide as feed additive
  • Application of N-acetyl-cysteine amide as feed additive
  • Application of N-acetyl-cysteine amide as feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A total of 100 piglets weaned at the age of 21±1 days, Du×long×big piglets were selected and randomly divided into two treatment groups (control group and test group) according to the principle of similar body weight. There were 5 replicates (pens) for each treatment, and 10 piglets per pen. The control group was fed a corn-soybean meal-based diet, and the experimental group was fed a corn-soybean meal-based diet supplemented with 0.05% N-acetylcysteine. After feeding for 28 days, the growth performance and intestinal mucosal antioxidant capacity of weaned piglets were measured. See Table 1 and Table 2 for the results.

[0017] Table 1 Growth performance of weaned piglets during the test period

[0018]

[0019] Note: Different lowercase letters are marked on the right shoulder of numbers in the same column, indicating significant difference (P<0.05). The following are similar.

[0020] The data in Table 1 shows that, compared with the control group during the tes...

Embodiment 2

[0025] 200 1-day-old Cobb broilers were selected and randomly divided into two treatment groups (control group and test group) according to the principle of similar body weight. There were 5 replicates (columns) for each treatment, and 10 rats in each column (half male and half male). The control group was fed a corn-soybean meal-based diet, and the test group was fed a corn-soybean meal-based diet with the addition of 0.03% N-acetylcysteine ​​amide in the total weight of the feed. After feeding for 42 days, the growth performance and intestinal mucosal antioxidant capacity of broilers were measured. The results are shown in Table 3 and Table 4.

[0026] Table 3 Growth performance of broilers during the test period

[0027]

[0028] The data in Table 3 show that, compared with the control group, adding 0.03% N-acetylcysteine ​​to the broiler feed had no effect on the average feed intake of the broilers, and significantly increased the average feed intake of 0-21 days and 0...

Embodiment 3

[0033] 240 heterogeneous gibel crucian carp with a body weight of 6.89±0.03 g were selected, randomly distributed in 8 aquariums, divided into 2 treatment groups, and N-acetylcysteinamide (0%, 0%, 0.1%), 4 replicates per group, 30 fish per replicate. The 8-week growth test was used to evaluate the effect of N-acetylcysteine ​​on the growth performance and serum antioxidant capacity of heterogeneous gibel carp. The results are shown in Table 5 and Table 6.

[0034] Table 5 Growth performance of heterogeneous gibel carp during the test period

[0035]

Relative weight gain %

Specific growth rate %

feed factor

Survival %

control group

807.14±24.12 b

3.47±0.12 b

1.56±0.05 a

98.20±5.0

test group

853.50±31.67 a

4.01±0.04 a

1.47±0.03 b

98.60±2.27

[0036] The data in Table 5 show that adding 0.1% N-acetylcysteine ​​to the diet of heterogeneous gibel carp can increase the relative weight gain rate by 5....

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Abstract

The invention discloses an application of N-acetyl-cysteine amide as a feed additive. N-acetyl-cysteine amide is characterized in that a molecular formula is C5H10N2O2S and molecular weight is 162.21. N-acetyl-cysteine amide can serve as the feed additive to be applied to monogastric animals such as swines and birds, ruminants such as cattle and sheep, herbivores such as horses and rabbits, and aquatic animals such as fish, shrimp and crabs. A use method comprises the steps that the feed additive at a weight ratio of 0.01%-0.1% of the total weight of feed is directly added to the feed; or the feed additive is mixed with an adsorbent to form a premix agent; and the feed additive can also be mixed with other feed additives or raw feed materials to form a premix compound, a concentrated material and the like for feeding the monogastric animals such as the swines and the birds, the ruminants such as the cattle and the sheep, the herbivores such as the horses and the rabbits, and the aquatic animals such as the fish, the shrimp and the crabs. The application has the prominent advantages that the characteristics of N-acetyl-cysteine amide that N-acetyl-cysteine amide is absorbed by animal tissues easily, and reduced glutathione in a cell is supplied quickly are applied, so that the oxidation resistance of an animal body is improved; an inflammatory factor level is lowered; immunological stress is alleviated; an effect of improving the disease resistance of the animals is achieved; use of microbiotic in the feed is reduced; consumption of the feed is reduced; and the production of high-quality nuisanceless animal products is facilitated.

Description

technical field [0001] The present invention relates to the use of N-acetylcysteine, in particular to the use in the field of animal feed additives. Background technique [0002] Oxidative stress is a harmful redox imbalance in the body and one of the important factors leading to diseases. The animal intestine is the most vulnerable organ to attack by oxygen free radicals. The intestinal tract is not only the main organ for digestion, absorption and metabolism of nutrients in animals, but also a very vigorous system for material metabolism and energy metabolism in animals, and it is also an important secretory and immune organ, so it is extremely vulnerable to excessive oxygen free radicals. Induce intestinal diseases. It is characterized by abnormal glandular secretion, intestinal damage, and increased intestinal mucosal permeability, leading to abnormal intestinal function and enterogenous infection. The above damages are not easy to detect in the state of chronic stress...

Claims

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Application Information

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IPC IPC(8): A23K1/16A23K1/18
Inventor 侯永清邱银生丁斌鹰
Owner WUHAN POLYTECHNIC UNIVERSITY
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