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Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning

A technology of composite nanofiber and electrospinning method, which is applied in fiber processing, textile and papermaking, filament/thread forming, etc. It can solve the problems of difficult to achieve antibacterial effect and complicated preparation process of nano silver, and achieve low price and low cost. Low, strong antibacterial effect

Inactive Publication Date: 2013-05-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above reasons, it is of great significance to prepare a new type of antibacterial nano-silver composite nanofiber felt. The current research literature and patents have articles on the use of nanofibers with different drug loading and nano-silver. However, the preparation process of nano-silver is complicated, and the antibacterial effect is relatively low. Difficult to reach

Method used

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  • Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning
  • Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Dissolve 0.1 g of PVPK90 white solid powder in 1 mL of water, in a silver nitrate solution with a concentration of 0.5 mol / L, magnetically stir for 1 h, and ultrasonically degas for 2 min.

[0036] The obtained solution was protected from microwaves for 1 min and stopped for 1 min for three consecutive times. After cooling down, 0.5 mL / h of alcohol was added and stirred continuously for 2 h to obtain a shell solution.

[0037] Dissolve 0.1 g of PVPK90 white solid powder and 0.02 g of ferulic acid in 1 mL of acetone, magnetically stir for 4 h, and ultrasonically degas for 5 min.

[0038] Put the former two under different propulsion pumps, and electrospin in a closed environment with a temperature of 20°C and a humidity of 25%. The specific conditions of spinning are: voltage 5kv, shell flow rate 3mL / h, core flow rate 0.5mL / h h, the receiving distance between the needle and the aluminum foil is 5cm.

[0039] Place the obtained drug-loaded nano-silver fiber mat in a vacu...

Embodiment 2

[0041] Dissolve 0.1 g of PVPK90 white solid powder in 1 mL of silver nitrate solution with a concentration of 1 mol / L, stir magnetically for 4 h, and degas by ultrasonication for 5 min.

[0042] The obtained solution was protected against microwaves for 2 minutes, stopped for 1 minute, and continued for three times. After cooling down to room temperature, 0.25 mL of alcohol was added and stirred continuously for 2 hours to obtain a shell solution.

[0043] Dissolve 0.1 g of polylactic acid and 0.02 g of ferulic acid in 1 mL of ethanol, stir for 4 h with magnetic force, and degas with ultrasonic for 5 min.

[0044] Put the former two under different propulsion pumps, and electrospin in a closed environment with a temperature of 25°C and a humidity of 50%. The specific conditions of spinning are: voltage 10kv, shell flow rate 1mL / h, core flow rate 1mL / h , the receiving distance between the needle and the aluminum foil is 15cm.

[0045] Place the obtained drug-loaded nano-silver...

Embodiment 3

[0047] Dissolve 0.08 g of PVPK90 white solid powder in 1 mL of silver nitrate solution with a concentration of 2 mol / L, magnetically stir for 10 h, and ultrasonically degas for 10 min.

[0048] The obtained solution was protected from microwaves for 3 minutes, stopped for 1 minute, and continued for three times. After cooling down, 0.02 g of PVP powder was added and stirred continuously for 2 hours to obtain a shell solution.

[0049] Dissolve 0.1 g of polylactic-glycolic acid and 0.02 g of ferulic acid in 1 mL of dichloromethane, magnetically stir for 4 h, and ultrasonically degas for 5 min.

[0050] Put the former two under different propulsion pumps, and electrospin in a closed environment with a temperature of 35°C and a humidity of 75%. The specific conditions of spinning are: voltage 15kv, shell flow rate 0.2mL / h, core flow rate 3mL / h h, the receiving distance between the needle and the aluminum foil is 25cm.

[0051] Place the obtained drug-loaded nano-silver fiber mat i...

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Abstract

The invention provides a preparation method for an antibacterial nano-silver composite nanofiber mat by electrostatic spinning. The preparation method comprises the following steps of: nano-silver is prepared by a microwave method, polyvinyl pyrrolidone is used as reducing agent and protective agent, and the nano-silver is prepared through microwave reduction reaction; the diameter of the nano-silver is 50-600nm; according to the electrostatic spinning technology, a coaxial nanofiber mat with the even diameter is obtained, wherein the shell of the coaxial nanofiber mat is PVP (polyvinyl pyrrolidone) nano-silver, and the core of the coaxial nanofiber mat is PVP carrying antibacterial; the diameter of the fiber is 300-700nm; and the obtained nanofiber mat has a better antibacterial effect. The method disclosed by the invention is continuous and feasible, is easy and simple to operate and is easy to industrialize. The obtained medicine carrying nanofiber mat is used for effective bacteria prevention, and the medicine has a nano-silver antibacterial accelerating action and can be used as trauma dressing. The coaxial carrying nano-silver can be used for releasing other medicines, can be used to implant into a slow release system and also can be used for the medical field, such as the tissue engineering scaffold.

Description

technical field [0001] The invention belongs to the field of preparation of antibacterial polymer nanofibers, and in particular relates to a method for preparing antibacterial nanosilver composite nanofiber mats by electrospinning. Background technique [0002] In the later stage of wound healing in patients with deep burns, there are often residual wounds that are difficult to heal, which not only lengthens the hospital stay, increases the pain of the patients, but also increases the economic burden of the patients. With the development of nano science and technology and its application in the medical field, nano-silver, a new type of external drug, has been widely used in clinical practice in recent years. [0003] There are many ways to prepare nanofibers, such as biological fermentation, flocculation precipitation, wet spinning, spray drawing, melt spinning, electrospinning and so on. However, electrospinning was first reported in 2001 by Ignatious et al. In their paten...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01D5/00
Inventor 朱利民张婳权静娄少峰
Owner DONGHUA UNIV
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