Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning

A technology of composite nanofiber and electrospinning method, which is applied in fiber processing, textile and papermaking, filament/thread forming, etc. It can solve the problems of difficult to achieve antibacterial effect and complicated preparation process of nano silver, and achieve low price and low cost. Low, strong antibacterial effect

Inactive Publication Date: 2013-05-01
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above reasons, it is of great significance to prepare a new type of antibacterial nano-silver composite nanofiber felt. The current research literature and patents have articles

Method used

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  • Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning
  • Preparation method for antibacterial nano-silver composite nanofiber mat by electrostatic spinning

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0034] Example 1

[0035] Dissolve 0.1 g of PVPK90 white solid powder in 1 mL of water with a concentration of 0.5 mol / L silver nitrate solution, magnetically stir for 1 h, and ultrasonically degas for 2 min.

[0036] The obtained solution was resisted to the microwave for 1 min, stopped for 1 min, and continued for three times. After cooling, 0.5 mL / h of alcohol was added, and stirring was continued for 2 h to obtain a shell solution.

[0037] Dissolve 0.1 g of PVPK90 white solid powder and 0.02 g of ferulic acid in 1 mL of acetone, stir magnetically for 4 hours, and ultrasonically degas for 5 minutes.

[0038] Put the first two under different propulsion pumps, electrospinning in a closed environment with a temperature of 20℃ and a humidity of 25%. The specific spinning conditions: voltage 5kv, shell flow rate 3mL / h, core flow rate 0.5mL / h, the receiving distance of the needle from the aluminum foil is 5cm.

[0039] The drug-loaded nano-silver fiber felt was dried in a vacuum drying...

Example Embodiment

[0040] Example 2

[0041] Dissolve 0.1 g of PVPK90 white solid powder in 1 mL of silver nitrate solution with a concentration of 1 mol / L, magnetically stir for 4 hours, and ultrasonically degas for 5 minutes.

[0042] The obtained solution was resisted to the microwave for 2 minutes, stopped for 1 minute, three times in a row, 0.25 mL of alcohol was added after the temperature dropped to room temperature, and the mixture was continuously stirred for 2 hours to obtain a shell solution.

[0043] 0.1 g of polylactic acid and 0.02 g of ferulic acid were dissolved in 1 mL of alcohol, magnetically stirred for 4 hours, and ultrasonically degassed for 5 minutes.

[0044] Put the first two under different propulsion pumps, electrostatic spinning in a closed environment with a temperature of 25℃ and a humidity of 50%. The specific spinning conditions are: voltage 10kv, shell flow rate 1mL / h, core flow rate 1mL / h , The receiving distance of the needle from the aluminum foil is 15cm.

[0045] Plac...

Example Embodiment

[0046] Example 3

[0047] Dissolve 0.08 g of PVPK90 white solid powder in 1 mL of silver nitrate solution with a concentration of 2 mol / L, magnetically stir for 10 hours, and ultrasonically degas for 10 minutes.

[0048] The obtained solution was resisted to the microwave for 3 minutes, stopped for 1 minute, and continued for three times. After cooling, 0.02 g of PVP powder was added, and the mixture was continuously stirred for 2 hours to obtain a shell solution.

[0049] 0.1 g of polylactic acid glycolic acid and 0.02 g of ferulic acid were dissolved in 1 mL of dichloromethane, magnetically stirred for 4 hours, and ultrasonically degassed for 5 minutes.

[0050] Put the first two under different propulsion pumps, electrospinning in a closed environment with a temperature of 35℃ and a humidity of 75%. The specific spinning conditions: voltage 15kv, shell flow rate 0.2mL / h, core flow rate 3mL / h, the receiving distance of the needle from the aluminum foil is 25cm.

[0051] The drug-loa...

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Abstract

The invention provides a preparation method for an antibacterial nano-silver composite nanofiber mat by electrostatic spinning. The preparation method comprises the following steps of: nano-silver is prepared by a microwave method, polyvinyl pyrrolidone is used as reducing agent and protective agent, and the nano-silver is prepared through microwave reduction reaction; the diameter of the nano-silver is 50-600nm; according to the electrostatic spinning technology, a coaxial nanofiber mat with the even diameter is obtained, wherein the shell of the coaxial nanofiber mat is PVP (polyvinyl pyrrolidone) nano-silver, and the core of the coaxial nanofiber mat is PVP carrying antibacterial; the diameter of the fiber is 300-700nm; and the obtained nanofiber mat has a better antibacterial effect. The method disclosed by the invention is continuous and feasible, is easy and simple to operate and is easy to industrialize. The obtained medicine carrying nanofiber mat is used for effective bacteria prevention, and the medicine has a nano-silver antibacterial accelerating action and can be used as trauma dressing. The coaxial carrying nano-silver can be used for releasing other medicines, can be used to implant into a slow release system and also can be used for the medical field, such as the tissue engineering scaffold.

Description

technical field [0001] The invention belongs to the field of preparation of antibacterial polymer nanofibers, and in particular relates to a method for preparing antibacterial nanosilver composite nanofiber mats by electrospinning. Background technique [0002] In the later stage of wound healing in patients with deep burns, there are often residual wounds that are difficult to heal, which not only lengthens the hospital stay, increases the pain of the patients, but also increases the economic burden of the patients. With the development of nano science and technology and its application in the medical field, nano-silver, a new type of external drug, has been widely used in clinical practice in recent years. [0003] There are many ways to prepare nanofibers, such as biological fermentation, flocculation precipitation, wet spinning, spray drawing, melt spinning, electrospinning and so on. However, electrospinning was first reported in 2001 by Ignatious et al. In their paten...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01D5/00
Inventor 朱利民张婳权静娄少峰
Owner DONGHUA UNIV
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