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Preparation method and applications of mesoporous carbon

A technology of mesoporous carbon and pore size, which is applied in the field of medicine to achieve the effect of large specific surface area, simple process operation, and non-degradable physiological compatibility

Inactive Publication Date: 2013-05-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, mesoporous carbon has attracted great interest as a new type of molecular sieve material, and a lot of research has been done in the fields of catalysis, adsorption, electrochemistry, sensors, storage, etc. However, as a carrier for oral insoluble drugs, it is used There are no relevant reports on improving the dissolution rate and oral bioavailability of poorly soluble drugs

Method used

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  • Preparation method and applications of mesoporous carbon
  • Preparation method and applications of mesoporous carbon
  • Preparation method and applications of mesoporous carbon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Accurately take 3g of hexadecylamine and add it to 400ml of water and isopropanol mixed solvent (volume ratio: 1:1) to dissolve it completely, add 15ml of tetraethyl orthosilicate and 3.5ml of ammonia water, stir to make the solution fully mixed and reacted , the reacted solution was subjected to high-pressure homogenization with a high-pressure homogenizer, left to stand for 16 hours, and the precipitate was collected by suction filtration or centrifugation, dried, and calcined at 600°C for 4 hours to remove the organic template to obtain a mesoporous silica template. The silica template was added to a solution containing 0.6g sucrose, 0.10ml sulfuric acid, and 4g water, mixed evenly, placed at 80°C for 6h to remove water, and then placed at 160°C for 6h for preliminary carbonization, and the product after preliminary carbonization was added to a solution containing 0.4 g sucrose, 0.08ml sulfuric acid, and 4g water were mixed evenly, placed at 80°C for 6 hours to remove...

Embodiment 2

[0038] Accurately take 4g of hexadecylamine and add it to 400ml of water and isopropanol mixed solvent (volume ratio: 1:1) to dissolve completely, add 15ml of tetraethyl orthosilicate and 3.5ml of ammonia water, stir to make the solution fully mixed and reacted , the reacted solution was subjected to high-pressure homogenization with a high-pressure homogenizer, left to stand for 16 hours, and the precipitate was collected by suction filtration or centrifugation, dried, and calcined at 600°C for 4 hours to remove the organic template to obtain a mesoporous silica template. The silica template was added to a solution containing 0.6g sucrose, 0.10ml sulfuric acid, and 4g water, mixed evenly, placed at 80°C for 6h to remove water, and then placed at 160°C for 6h for preliminary carbonization, and the product after preliminary carbonization was added to a solution containing 0.4 g sucrose, 0.08ml sulfuric acid, and 4g water were mixed evenly, placed at 80°C for 6 hours to remove mo...

Embodiment 3

[0040] Accurately take 5g of hexadecylamine and add it to 400ml of water and isopropanol mixed solvent (volume ratio: 1:1) to dissolve it completely, add 15ml of tetraethyl orthosilicate and 3.5ml of ammonia water, stir to make the solution fully mixed and reacted , the reacted solution was subjected to high-pressure homogenization with a high-pressure homogenizer, left to stand for 16 hours, and the precipitate was collected by suction filtration or centrifugation, dried, and calcined at 600°C for 4 hours to remove the organic template to obtain a mesoporous silica template. The silica template was added to a solution containing 0.6g sucrose, 0.10ml sulfuric acid, and 4g water, mixed evenly, placed at 80°C for 6h to remove water, and then placed at 160°C for 6h for preliminary carbonization, and the product after preliminary carbonization was added to a solution containing 0.4 g sucrose, 0.08ml sulfuric acid, and 4g water were mixed evenly, placed at 80°C for 6 hours to remove...

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Abstract

The invention belongs to the technical field of medicine, and relates to mesoporous carbon and a preparation process thereof, and an application of the mesoporous carbon in insoluble drug delivery systems. According to the process, a hard template method is adopted to prepare the mesoporous carbon, wherein mesoporous silica is adopted as a template, sucrose is adopted as a carbon source, and sulfuric acid is adopted as a catalyst to prepare the mesoporous carbon, wherein the prepared mesoporous carbon has characteristics of large specific surface area, stable property, no toxic-side effect and good biocompatibility, and can be adopted as a insoluble drug carrier. According to the present invention, a solvent method and a melting method are adopted to carry out drug embedding and adsorption so as to achieve uniform dispersion of the drug in the pores and on the surface of the carrier; with the drug delivery system, water solubility of insoluble drugs can be significantly enhanced, and in vitro dissolution rate and oral bioavailability can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method of spherical mesoporous carbon with biological activity and physiological compatibility and its application as an insoluble drug carrier. Background technique [0002] Due to the advantages of strong compliance, good stability, and economical safety, oral preparations have an absolute advantage in the market sales ratio, and are currently the preferred route of administration for most drugs. However, more than 1 / 3 of the drugs in the United States Pharmacopoeia, which contains the most drugs, are poorly water-soluble drugs; at the same time, about 40% of the drugs are poorly water-soluble drugs in the research of innovative drugs. Difficulty in drug dissolution greatly affects its oral bioavailability. Especially for Class II drugs in the classification of biopharmaceuticals, that is, drugs that are difficult to dissolve and absorb easily, the dissolution rat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B31/02A61K47/04A61K9/14A61K9/16C01B32/00C01B32/05
Inventor 王思玲姜同英赵鹏
Owner SHENYANG PHARMA UNIVERSITY
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