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Levamlodipine besylate tablet and preparation method thereof

A kind of technology of levamlodipine besylate and levamlodipine besylate, applied in the field of levamlodipine besylate tablet and preparation thereof, can solve problems such as complicated process, potential safety hazards, etc., and achieve simple preparation process and convenient operation , The effect of low production cost

Active Publication Date: 2013-06-05
ZHEJIANG ANGLIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above patented products have improved the dissolution rate and stability, but the process is complicated, and a large amount of lipid materials are added, which will bring greater safety hazards to patients with high cholesterol.

Method used

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  • Levamlodipine besylate tablet and preparation method thereof
  • Levamlodipine besylate tablet and preparation method thereof
  • Levamlodipine besylate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 levamlodipine besylate tablets

[0024]

[0025] Preparation Process:

[0026] (1) Dissolve levamlodipine besylate and polyethylene glycol 300 in 1L of ethanol, spray the formed solution onto lactose pellets in a fluidized bed, coat them and dry them to obtain drug-loaded pellets;

[0027] (2) Mix uniformly the drug-loaded pellets obtained in step (1) with low-substituted hydroxypropyl cellulose, microcrystalline cellulose and magnesium stearate, and directly compress into tablets to obtain levamlodipine besylate tablets.

Embodiment 2

[0028] The preparation of embodiment 2 levamlodipine besylate tablets

[0029]

[0030] Preparation Process:

[0031] (1) Dissolve levamlodipine besylate and polyethylene glycol 400 in 1L of ethanol, spray the formed solution onto lactose pellets in a fluidized bed, coat them and dry them to obtain drug-loaded pellets;

[0032] (2) Mix uniformly the drug-loaded pellets obtained in step (1) with crospovidone, microcrystalline cellulose, starch and magnesium stearate, and directly compress into tablets to obtain levamlodipine besylate tablets.

Embodiment 3

[0033] The preparation of embodiment 3 levamlodipine besylate tablets

[0034]

[0035] Preparation Process:

[0036] (1) Dissolve levamlodipine besylate and polyethylene glycol 600 in 1L of ethanol, spray the formed solution on lactose pellets in a fluidized bed, coat them and dry them to obtain drug-loaded pellets;

[0037] (2) Mix uniformly the drug-loaded pellets obtained in step (1) with low-substituted hydroxypropyl cellulose, microcrystalline cellulose and magnesium stearate, and directly compress into tablets to obtain levamlodipine besylate tablets.

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Abstract

The invention discloses a levamlodipine besylate tablet. The tablet is prepared by mixing a medicine carrying pellet containing levamlodipine besylate and pharmaceutically-accepted accessories and then carrying out direct compression, wherein the medicine carrying pellet is prepared by using the following method comprising the following steps of: weighting levamlodipine besylate and polyethylene glycol according to the weight ratio of 1: (4-8), then, dissolving levamlodipine besylate and polyethylene glycol into an organic solvent; and spraying the formed solution on a lactose pellet in a fluidized bed, coating and drying to obtain the medicine carrying pellet. The levamlodipine besylate raw material is coated on the outer layer of the lactose pellet and medicine is uniformly distributed on the surface of the pellet, so that the specific surface area of the medicine is greatly increased; and the raw material can be rapidly released, and thus, the medicine dissolution rate and the bioavailability of the levamlodipine besylate tablet are increased.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a levamlodipine besylate tablet and a preparation method thereof. Background technique [0002] Amlodipine besylate is the third-generation 1,4-dihydropyridine calcium ion antagonist successfully developed by Pfizer Pharmaceuticals Co., Ltd. in the mid-1980s. Its mechanism of action is to relax vascular smooth muscle and dilate coronary arteries, improve lateral It can improve myocardial ischemia and hypoxia, and the effect is mild and long-lasting. It is convenient to take and has mild adverse reactions. It is mainly used in the treatment of hypertension, angina pectoris, and heart failure complicated by hypertension or coronary heart disease. The calcium antagonistic activity of amlodipine besylate L-isomer is 1000 times that of D-isomer, and is 2 times of racemate. Levoamlodipine besylate can be used as an antianginal drug, and it is also effec...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4422A61K47/26A61P9/12A61P9/10A61P9/04
Inventor 方南平杨国栋徐成苗严立勇马海岭
Owner ZHEJIANG ANGLIKANG PHARMA
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