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Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker

A calcium channel blocker and receptor antagonist technology, applied in cardiovascular system diseases, pill delivery, drug combination, etc., can solve problems such as unstable blood pressure lowering effect, and achieve kidney protection, stable and effective blood pressure reduction, and blood vessel selection. high sex effect

Inactive Publication Date: 2013-06-05
吉林省博大伟业制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the antihypertensive effect is unstable, sometimes too fast or too low, resulting in adverse reactions such as cough, abdominal pain, fatigue or dizziness

Method used

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  • Compound preparation containing angiotensin II receptor antagonist and calcium channel blocker

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] Preparation of olmesartan medoxomil granules: Mix olmesartan medoxomil, lactose, and microcrystalline cellulose evenly, pass through a No. 5 sieve, add pregelatinized starch, sodium carboxymethyl starch, and make a soft material with absolute ethanol, 2 Granulate with a No. sieve, dry at 40-45°C, pass through a No. 3 sieve for granulation after testing the moisture content, and set aside. The content of intermediates needs to be determined.

[0019] Preparation of benidipine hydrochloride granules: crush benidipine hydrochloride through a No. 9 sieve, and the auxiliary materials lactose and starch are respectively passed through a No. 5 sieve. Weigh the prescribed amount of benidipine hydrochloride, lactose and starch, add equal amounts and mix evenly, add the prescribed amount of 10% polyvinyl alcohol aqueous solution to make a soft material, granulate with No. 2 sieve, dry at 60°C for 2 hours, Whole, spare. Determination of intermediate content.

Embodiment 1

[0021] Weigh 2 mg of benidipine hydrochloride / 20 mg of olmesartan medoxomil in proportion, add 0.6% magnesium stearate, mix uniformly and press into tablets.

Embodiment 2

[0023] Take benidipine hydrochloride 2mg / olmesartan medoxomil 40mg in proportion, add 0.6% magnesium stearate, mix and press evenly.

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Abstract

The invention provides a compound preparation containing an angiotensin II receptor antagonist and a calcium channel blocker. The compound preparation is prepared from benidipine hydrochlorine and olmesartan medoxomil. The compound preparation has the characteristics of stable and effective decomposition, less side effects, high safety, good tolerance and the like, and is suitable for strengthening long-term treatment compliance.

Description

[0001] technical field [0002] The invention discloses a compound preparation containing an angiotensin II receptor antagonist and a calcium channel blocker, which belongs to the technical field of medicine. Background technique [0003] Benidipine hydrochloride is a long-acting calcium channel blocker with high selectivity to blood vessels, dilates blood vessels, lowers blood pressure and significantly increases coronary and vertebral artery blood flow, and has antihypertensive and angina pectoris effects. It can significantly reduce urinary albumin excretion, reduce left ventricular mass index in patients with severe left ventricular hypertrophy, protect the kidney and heart, and have a good preventive effect on stroke. Occasional increases in reflex heart rate during calcium channel blocker therapy, which may present with intrinsic palpitations; a common side effect is ankle edema, which usually leads to discontinuation of the drug. However, olmesartan medoxomil is an a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K31/4178A61K9/20A61P9/12
Inventor 苏焕臣李旭
Owner 吉林省博大伟业制药有限公司
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