The invention relates to a new
crystal form of a sartan
drug as well as a preparation method and application thereof, and belongs to the field of pharmaceutical chemicals. The invention discloses a
sacubitril valsartan trisodium trihydrate eutectic composed of an
angiotensin receptor antagonist and an
enkephalinase inhibitor for treating hypertension or
heart failure and a preparation method of the
sacubitril valsartan trisodium trihydrate eutectic. The obtained
crystal is analyzed by an X-
ray powder diffraction spectrogram, and the characteristic absorption peaks 2 theta are located at 4.2 + / -0.2 degrees, 5.0 + / -0.2 degrees, 5.4 + / -0.2 degrees, 9.7 + / -0.2 degrees, 12.6 + / -0.2 degrees, 17.0 + / -0.2 degrees, 18.1 + / -0.2 degrees, 19.4 + / -0.2 degrees, 21.3 + / -0.2 degrees and 23.0 + / -0.2 degrees. The new eutectic
crystal form disclosed by the invention is simple in preparation method, the crystal is easy to separate, and experiments show that the hygroscopicity and the stability of the neweutectic crystal form are superior to those of the existing eutectic crystal form, so that the new eutectic crystal form is favorable for being prepared into an oral
solid preparation and
processing and producing the oral
solid preparation, and can be used for treating hypertension or
heart failure.