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Venlafaxine hydrochloride slow-release capsule and preparation method thereof

A technology for venlafaxine hydrochloride and sustained-release capsules, which is applied in the direction of pharmaceutical formulas, medical preparations containing no active ingredients, medical preparations containing active ingredients, etc., and can solve the problem of complex preparation equipment, long production process and lack of economic Environmental protection methods and other issues to achieve the effect of improving the sustained release effect, simple equipment, and avoiding adhesion

Inactive Publication Date: 2013-07-03
KUNMING JIDA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The methods provided in these documents use techniques such as pellets, double-layer tablets or osmotic pump perforated semi-permeable membranes to achieve the purpose of sustained release. The required preparation equipment is more complicated and the production process is longer.
[0009] All in all, the preparation of sustained-release preparations of venlafaxine hydrochloride currently lacks a simple, effective, economical and environmentally friendly method

Method used

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  • Venlafaxine hydrochloride slow-release capsule and preparation method thereof
  • Venlafaxine hydrochloride slow-release capsule and preparation method thereof
  • Venlafaxine hydrochloride slow-release capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Composition of pill core:

[0030] Venlafaxine hydrochloride 35%, microcrystalline cellulose 60%, fumed silicon dioxide 3.5%, Tween-80 1%, hypromellose 0.5%.

[0031] Sustained release coating composition:

[0032] Polyacrylic resin 3%, talc 6%, macrogol 6000 2%, sodium lauryl sulfate 1%.

[0033] The preparation method is:

[0034] (1) Venlafaxine hydrochloride, microcrystalline cellulose and fumed silicon dioxide are mixed;

[0035] (2) adding a mixed aqueous solution of Tween-80 and hypromellose to the resulting mixture;

[0036] (3) Extrude, spheronize, and dry to obtain a pill core;

[0037] (4) Dissolving polyethylene glycol and sodium lauryl sulfate in water, adding polyacrylic acid resin and talcum powder, to obtain a slow-release coating solution;

[0038] (5) coating the pill core with coating solution to obtain sustained-release pellets;

[0039] (6) Put the sustained-release pellets into hollow capsules to obtain venlafaxine hydrochloride sustained-rel...

Embodiment 2

[0042] Composition of pill core:

[0043] Venlafaxine hydrochloride 45%, microcrystalline cellulose 50%, fumed silicon dioxide 1.5%, Tween-80 2%, hypromellose E5 1.5%.

[0044] Sustained release coating composition:

[0045] Polyacrylic resin 5%, talc 5%, polyethylene glycol 6000 1%, sodium lauryl sulfate 0.1%.

[0046] The preparation method is:

[0047] (1) Venlafaxine hydrochloride, microcrystalline cellulose and fumed silicon dioxide are mixed;

[0048] (2) adding a mixed aqueous solution of Tween-80 and hypromellose to the resulting mixture;

[0049] (3) Extrude, spheronize, and dry to obtain a pill core;

[0050] (4) Dissolving polyethylene glycol and sodium lauryl sulfate in water, adding polyacrylic acid resin and talcum powder, to obtain a slow-release coating solution;

[0051](5) coating the pill core with coating solution to obtain sustained-release pellets;

[0052] (6) Put the sustained-release pellets into hollow capsules to obtain venlafaxine hydrochlorid...

Embodiment 3

[0055] Composition of pill core:

[0056] Venlafaxine hydrochloride 50%, microcrystalline cellulose 45%, fumed silicon dioxide 1%, Tween-80 3%, hypromellose 1%.

[0057] Sustained release coating composition:

[0058] Polyacrylic resin 12%, talc powder 0.5%, polyethylene glycol 6000 0.1%, sodium lauryl sulfate 0.05%.

[0059] The preparation method is:

[0060] (1) Venlafaxine hydrochloride, microcrystalline cellulose and fumed silicon dioxide are mixed;

[0061] (2) adding a mixed aqueous solution of Tween-80 and hypromellose to the resulting mixture;

[0062] (3) Extrude, spheronize, and dry to obtain a pill core;

[0063] (4) Dissolving polyethylene glycol and sodium lauryl sulfate in water, adding polyacrylic acid resin and talcum powder, to obtain a slow-release coating solution;

[0064] (5) coating the pill core with coating solution to obtain sustained-release pellets;

[0065] (6) Put the sustained-release pellets into hollow capsules to obtain venlafaxine hydro...

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PUM

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Abstract

The invention relates to a venlafaxine hydrochloride slow-release capsule and a preparation method thereof. A drug-containing core of the slow-release capsule comprises venlafaxine hydrochloride, microcrystalline cellulose, gas phase silica, Tween-80, and hydroxypropyl methylcellulose; a slow-release coating comprises polyacrylic resin, talcum powder, polyethylene glycol and lauryl sodium sulfate. The invention realizes a pure water system for the capsule production by the addition of gas phase silica to change material flowing, and the selection of slow-release coating. The venlafaxine hydrochloride slow-release capsule prepared by the system is stable in drug release, has effective continuous release time of 24 hours, and is taken only once a day. The method is simple in process, mild in condition, free of any organic solvent, low in equipment requirements, and suitable for industrial production.

Description

technical field [0001] The invention relates to an antidepressant drug and a preparation method thereof, in particular to a venlafaxine hydrochloride preparation and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] With the increase of work and life pressure, people's mental pressure is also increasing, making depression a common disease with high incidence in modern society. According to statistics, the number of patients with depression worldwide accounts for 11% of the total population, about 770 million people. Depression is a mental disorder or affective disorder with depression as the main clinical manifestation caused by various reasons, and about 15% of patients are accompanied by suicidal tendencies. Currently, depression ranks fourth among the top ten diseases in the world. According to the prediction of the World Health Organization, by 2020, depression will become the second largest killer of h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/137A61K47/38A61P25/24
Inventor 马维波冯朴纯罗晓云殷勤红
Owner KUNMING JIDA PHARMA
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