Preparation method of electrochemical transducer capable of rapidly and selectively detecting azithromycin

Abstract

The invention discloses a preparation method of an electrochemical transducer capable of rapidly and selectively detecting azithromycin. The preparation method comprises the following steps of: mixing graphene oxide and a multi-wall carbon nanotube according to a certain proportion by utilizing a blending method, thus preparing an electrode compounded with the graphene oxide and the multi-wall carbon nanotube; and carrying out electrochemical detection on the azithromycin in a solution taking sodium bicarbonate (0.05 mol / L) as a supporting electrolyte, wherein the combined electrode can display good electrocatalytic activity on the azithromycin. The electrode can realize efficient, sensitive and selective detection on the azithromycin, and can be successfully applied for measuring azithromycin content in different azithromycin agents and azithromycin remained in livestock bodies such as pigs, cattles, sheep, chickens and ducks. The electrochemical transducer prepared by the preparation method provided by the invention has the advantages that an electrode material is easy to prepare, the cost is low, the operation is simple and convenient, the preparation method is rapid and efficient, the sensitivity is high, and the like.

Description

technical field [0001] The invention belongs to the field of electrochemical sensors, and relates to a preparation method of an electrochemical sensor for rapid and selective detection of azithromycin. Background technique [0002] Azithromycin is a macrolide antibiotic, a nitrogen-containing 15-membered ring erythromycin derivative obtained from erythromycin oxime through Beckmann rearrangement, reduction, N-methylation and other reactions. In recent years, the abuse of antibiotics and the residues of antibiotics in food have aroused widespread concern. Azithromycin, as a new generation of macrolide antibiotics with the fastest sales growth, is widely used in In the livestock, poultry and aquaculture industries, the antibiotic resistance of animal-derived pathogens caused by it has also brought harm to human, animal health and the environment. A variety of assay methods for azithromycin have been established at present, and the widely used method is mainly chromatography, ...

AI Technical Summary

Problems solved by technology

However, the electrochemical oxidation detection of azithromycin and the residues of azithromycin in livestock by using the composite electrode of graphene oxide and multi-walled carbon nanotubes has not been reported, and the detection range, sensitivity, selectivity and stability of the current electrochemical detection method for azithromycin are still to be determined. further improvement

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