Preparation method of smellless coated enrofloxacin preparation
A technology of enrofloxacin and preparations, which is applied in the field of preparation of odorless coated enrofloxacin preparations, can solve problems such as easy moisture absorption and caking, reduced drug efficacy, and troublesome production and processing, so as to avoid stomach cramps in feeding animals , reduce the loss of drug efficacy, and avoid the effect of photodecomposition
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Embodiment 1
[0011] (1) Weigh each raw material:
[0012] Enrofloxacin 8kg
[0013] Polyacrylic resin type II 0.05kg
[0014] Polyethylene glycol 1.95kg
[0015] Stearic acid 60kg
[0016] β-cyclodextrin 30kg
[0017] 55kg of water
[0018] Anhydrous ethanol 40kg
[0019] (2) Preparation method: In the first step, mix β-cyclodextrin and water, and stir into a uniform state, add enrofloxacin and polyethylene glycol, and stir the mixture in a ball mill for 12 hours to fully include , that is, to obtain enrofloxacin inclusion compound; the second step is to dry the completed inclusion compound at 65°C, crush it, and pass it through an 80-mesh analytical sieve; the third step is to put stearic acid into the reaction kettle , heated to a transparent liquid state, put in the crushed enrofloxacin inclusion compound, stir and mix, spray, and freeze-dry to obtain microcapsule particles of about 20 mesh; the fourth step is to dissolve the hydrophobic Material (polyacrylic acid resin type II),...
Embodiment 2
[0021] (1) Weigh each raw material:
[0022] Enrofloxacin 15kg
[0023] Polyacrylic resin type II 0.1kg
[0024] Polyethylene glycol 4.9kg
[0025] Stearic acid 50kg
[0026] β-cyclodextrin 30kg
[0027] 50kg of water
[0028] Anhydrous ethanol 40kg
[0029] (2) Preparation method: In the first step, mix β-cyclodextrin and water, and stir into a uniform state, add enrofloxacin and polyethylene glycol, and stir the mixture in a ball mill for 12 hours to fully include , that is, to obtain enrofloxacin inclusion compound; the second step is to dry the completed inclusion compound at 65°C, crush it, and pass it through an 80-mesh analytical sieve; the third step is to put stearic acid into the reaction kettle , heated to a transparent liquid state, put in the crushed enrofloxacin inclusion compound, stir and mix, spray, and freeze-dry to obtain microcapsule particles of about 20 mesh; the fourth step is to dissolve the hydrophobic Material (polyacrylic acid resin type II), ...
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