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Composite bacteriostatic agent for reducing irritation

A technology of bacteriostatic agent and solution, applied in the field of compound bacteriostatic agent, can solve the problems of poor water solubility of salicylic acid, large skin irritation, application limitation, etc., and achieve the effect of obvious bacteriostatic effect, reducing irritation and realizing stability.

Inactive Publication Date: 2013-08-28
惠州市绿亚生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Salicylic acid has been used as an active ingredient in the treatment of acne, but due to its poor water solubility, it is easy to decompose when exposed to light, and the most important thing is that it is highly irritating to the skin, so its application is limited

Method used

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  • Composite bacteriostatic agent for reducing irritation
  • Composite bacteriostatic agent for reducing irritation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Accurately weigh 2g of salicylic acid, dissolve it in 50ml of 60% ethanol solution; then accurately weigh 2g of water-soluble chitosan oligosaccharide with a molecular weight of 2000Da~30000Da (purchased in the market), dissolve it in 50ml of water at 60°C; Add the sylic acid ethanol solution into the above chitosan oligosaccharide solution, stir and mix evenly. After the obtained mixed solution is homogenized by the colloid mill, the drying conditions are as follows: the air inlet temperature is 180°C, the tuyere temperature is 80°C, and the feed Quantity is dried under the condition of 8.6ml / min, obtains the oligochitosaccharide / salicylic acid microcapsule of 2.1g, productive rate is 52%, and the loading capacity and inclusion rate of salicylic acid are respectively 19.1% and 21.5%.

[0021] Accurately weigh and prepare according to the ratio of: 0.125 mg salicylic acid, 16 mg tea tree essential oil and 1 g cream, stir and mix well to obtain the compound inhibitor.

Embodiment 2

[0023] Accurately weigh 2g of salicylic acid, dissolve it in 50ml of 20% ethanol solution; then accurately weigh 2g of water-soluble chitosan oligosaccharide with a molecular weight of 2000Da~30000Da (market purchase), dissolve it in 50ml of water at 60°C; Add the sylic acid ethanol solution into the above chitosan oligosaccharide solution, stir and mix evenly. After the obtained mixed solution is homogenized by the colloid mill, the drying conditions are as follows: the air inlet temperature is 190°C, the tuyere temperature is 90°C, and the feed Quantity is dried under the condition of 10.6ml / min, obtains the oligochitosaccharide / salicylic acid microcapsule of 2.2g, productive rate is 55%, and the loading capacity and inclusion rate of salicylic acid are respectively 19.8% and 21.8%.

[0024] Accurately weigh and prepare according to the ratio of: 0.25 mg salicylic acid, 48 mg tea tree essential oil and 1 g cream, stir and mix well to obtain the compound inhibitor.

Embodiment 3

[0026] Accurately weigh 2g of salicylic acid, dissolve it in 50ml of 40% ethanol solution; then accurately weigh 3g of water-soluble chitosan oligosaccharide with a molecular weight of 2000Da~30000Da (purchased in the market), dissolve it in 50ml of water at 60°C; Add the sylic acid ethanol solution into the above chitosan oligosaccharide solution, stir and mix evenly. After the obtained mixed solution is homogenized by the colloid mill, the drying conditions are as follows: the air inlet temperature is 200°C, the tuyere temperature is 80°C, and the feed Quantity is dried under the condition of 13.6ml / min, obtains the oligochitosaccharide / salicylic acid microcapsule of 3.3g, and productive rate is 56%, and the loading capacity and inclusion rate of salicylic acid are respectively 15.3% and 17.7%.

[0027] Accurately weigh and prepare according to the ratio of: 0.375 mg salicylic acid, 32 mg tea tree essential oil and 1 g cream, stir and mix well to obtain the compound inhibitor...

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Abstract

The invention discloses a composite bacteriostatic agent for reducing irritation. The composite bacteriostatic agent comprises a microcapsule, tea tree essential oil and a cream, wherein the microcapsule is prepared by taking salicylic acid as a core material and chitosan oligosaccharide as a wall material. Each gram of bacteriostatic agent contains 0.5-5mg of salicylic acid, 16-320mg of tea tree essential oil and the balance of cream. A chitosan oligosaccharide solution is used as a wall material solution, the salicylic acid is dissolved in an ethanol solution to form a core material solution, and then, the wall material solution and the core material solution are mixed, stirred and blended uniformly, sprayed and dried to obtain the composite bacteriostatic agent. The composite bacteriostatic agent prepared by the invention has a remarkable bacteriostatic effect on staphylococcus aureus, staphylococcus epidermidis and propionibacterium acnes, and achieves the same bacteriostatic effect even if the usage amount of the salicylic acid is reduced. The composite bacteriostatic agent has the advantages of simple preparation process, remarkable bacteriostatic effect, small usage amount, remarkable controlled / slow-release effect, short production period, low production cost and the like.

Description

technical field [0001] The invention belongs to the field of medicine and cosmetics, and in particular relates to a compound antibacterial agent for reducing irritation. Background technique [0002] Acne is a common skin disease with a chronic course and easy recurrence, mostly in adolescents aged 18-24. The disease can seriously affect the physical and mental health of adolescents. Although there are many treatment methods, a generally accepted and ideal treatment plan has not been found so far. The etiology is generally believed to be that hormones induce sebaceous glands to secrete too much oil, and at the same time, hyperkeratosis of hair follicles forms fat plugs. Under anaerobic environment, anaerobic bacteria proliferate in large numbers, produce lipolytic enzymes, separate sebum to produce free acid, stimulate hair follicles and cause inflammation And the mixed infection of other acne-causing bacteria eventually causes inflammation around the hair follicle. Staph...

Claims

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Application Information

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IPC IPC(8): A61K36/61A61K9/50A61K47/36A61K8/97A61K8/73A61K8/36A61K8/11A61P17/10A61P31/04A61Q19/00A61K31/60
Inventor 纪红兵赵明月杨祖金
Owner 惠州市绿亚生物材料有限公司
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