Amino sugar-containing glucan, method for producing same and use of same

Abstract

The purpose of the present invention is to provide a glucosamine-containing glucan, a modified product of the glucosamine-containing glucan and a conjugate of the glucosamine-containing glucan. This glucosamine-containing glucan is a glucosamine-containing glucan wherein at least one glucosamine residue is bound, by an alpha-1,4 bond, to each of two or more non-reducing terminals among a plurality of non-reducing terminals of a branched alpha-1,4 glucan but no glucosamine residue is present at any position other than non-reducing terminals of the branched alpha-1,4 glucan, and the glucan has a polymerization degree from 15 to 4*10<5> (inclusive). This glucosamine-containing glucan can be provided by having alpha-glucan phosphorylase act on an aqueous solution that contains a branched alpha-1,4 glucan and glucosamine-1-phosphate.

Description

technical field

[0001] The present invention relates to dextran having at least 1 (preferably 2 or more) amino monosaccharide residues on each of at least 1 non-reducing end, its modified products and conjugates, as well as its preparation method and its use. More preferably, the present invention relates to glucans having at least 1 (preferably 2 or more) glucosamine residues on each of at least 1 non-reducing end, modified products and conjugates thereof, and their Preparation method and its use. The dextran, modified products and conjugates thereof of the present invention may have the function of non-covalently binding to nucleic acid to increase the apparent molecular weight of nucleic acid. Background technique

[0002] The active ingredients of drugs are rapidly changing from chemically synthesized stable low-molecular-weight compounds to unstable substances that are easily degraded in the blood, such as proteins, antibodies, and nucleic acids. Therefore, it is nec...

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