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53 results about "Alpha glucan" patented technology
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Α-Glucans (alpha-glucans) are polysaccharides of D-glucose monomers linked with glycosidic bonds of the alpha form. α-Glucans use cofactors in a cofactor site in order to activate a glucan phosphorylase enzyme. This enzyme causes a reaction that transfers a glucosyl portion between orthophosphate and α-I,4-glucan. The position of the cofoactors to the active sites on the enzyme are critical to the overall reaction rate thus, any alteration to the cofactor site leads to the disruption of the glucan binding site.
Medical-use two part reactive adhesive and medical-use resin having self-degradation property
Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.
Owner:BERTELSMANN MUSIC GROUP
Branched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses
ActiveUS20100120710A1High yieldA large amountOrganic active ingredientsCosmetic preparationsD-GlucoseGlucose polymers
The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows:
- (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4;
- (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates;
- (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and
- (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
Owner:HAYASHIBARA CO LTD
Medical-use two part reactive adhesive and medical-use resin having self-degradation property
Medical-use two-part adhesive comprising; first part comprised of an aqueous solution or a powder of aldehyde-groups-introduced alpha-glucan; and second part comprised of an aqueous solution or a powder of amino-groups-containing polymer that is formed of a polymer chain of amino-group-containing units and has a molecular weight in a range of 1000 to 20,000; as well as medical-use hydrogel resin obtained by curing the adhesive. A mixture of the first and second parts, at a time of mixing them to form the hydrogel has pH in a range of 5.0 to 8.0. In a preferred embodiment, the amino-groups-containing polymer is epsilon-poly-L-lysine produced by microorganism or by enzyme.
Owner:BERTELSMANN MUSIC GROUP
Personal Care Compositions Comprising Alpha-Glucans and/or Beta-Glucans
Personal care compositions containing at an alpha-glucan and / or beta-glucan; at least one additional skin and / or hair care active selected from the group consisting of sugar amine, vitamin B3, retinoids, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), menthyl anthranilate, cetyl pyridinium chloride, ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, tetrahydrocurcumin, their derivatives, their precursors, and combinations thereof; and a dermatologically acceptable carrier.
Owner:THE PROCTER & GAMBLE COMPANY
Method for extracting water soluble beta glucan from fruiting bodies of hericium erinaceus and product thereof
The invention discloses a method for extracting water soluble beta glucan from fruit bodies of hericium erinaceus, which comprises the steps of: adopting the fruit bodies of the hericium erinaceus as an extraction raw material; performing alkali extraction, ethanol deposition, alpha amylase hydrolysis and acid hydrolysis; and drying a precipitate after the ethanol deposition to obtain the water soluble beta glucan. The method also solves the problem of poor water solubility of beta glucan when alpha glucan is removed; polysaccharide obtained by the method is soluble beta glucan, the polysaccharide, namely the beta glucan of the fruit bodies of the hericium erinaceus has high content, and the average molecular weights are between 2,000 and 200, 000 daltons; and the water soluble beta glucan has excellent water solubility and can be used as a raw material for preparing medicaments, health care products and food.Owner:中科优术(黑龙江)科技产业有限公司
Chlamydomonus nivalis cream and preparing method thereof
ActiveCN104940121AEasy to useCosmetic preparationsToilet preparationsMicrocrystalline waxProtection Skin
The invention discloses chlamydomonus nivalis cream and a preparing method thereof. The chlamydomonus nivalis cream is prepared from carbomer, chlamydomonus nivalis extracts, alpha-glucan, chicory fructo-oligosaccharide, jellyfish collagen, Algisium C, phenoxyethanol, 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, triethanolamine, ethanol, microcrystalline wax, base emulgator, texture agent and water. The chlamydomonus nivalis cream is composed of oil capsules and aqua gel. Water and oil double films are formed when the cream is used, oil gel and hydrogel interact, the white oil capsules dissolve after the product is applied to skin, and the functions of protecting skin and delivering oil particles and nutrients to skin are realized through the formation of the water film peculiarly formed by the hydrogel and the formation of the oil film. Meanwhile, the comprehensive nursing type chlamydomonus nivalis cream is easy and convenient to use.
Owner:广州丽丰化妆品制造有限公司
Cosmetic composition for relieving senescence, as well as preparation method and application thereof
InactiveCN105687059ANon-irritatingNo greasy feelingCosmetic preparationsToilet preparationsPolyethylene glycolOperability
The invention discloses a cosmetic composition for relieving senescence. The composition is prepared from the following components: rock rose extract, fructus evodiae extract, achillea millefolium extract, saussurea involucrata extract, bamboo leaf flavonoid, alpha-glucan, rhamnogalacturonan, glutamic acid, sweet almond oil, metallothionein, caffeine, pitaya enzyme, ursolic acid, fermiskin, vitamin E, lecithin, caprylyl / capryl polyethylene glycol glucoside, 1,2-propylene glycol, isopropyl myristate and deionized water. The cosmetic composition has the advantages of application safety, stability, attractive appearance, small skin irritation and no greasy feeling, and can quickly infiltrate skin to achieve the effect of relieving senescence since the effective ingredients are reasonably mixed and synergized jointly. The invention further discloses a method for preparing the cosmetic composition. The method has simple process steps, strong operability, no special requirement for equipment and low preparation cost. The product prepared by the method has good stability and attractive appearance.
Owner:余云丰
Regulation of mammalian keratinous tissue using personal care compositions comprising cetyl pyridinium chloride
InactiveUS20070020221A1Tactile feel is improvedImprove efficiencyCosmetic preparationsCationic surface-active compoundsDehydroacetic acidRetinoid
Personal care composition including a first skin and/or hair care active cetyl pyridinium chloride; and at least one additional skin and/or hair care active selected from the group consisting of tetrahydrocurcumin, sugar amine, vitamin B3, retinoids, hydroquinone, peptides, phytosterol, dialkanoyl hydroxyproline, hexamidine, salicylic acid, n-acyl amino acid compounds, sunscreen actives, water soluble vitamins, oil soluble vitamins, hesperedin, mustard seed extract, glycyrrhizic acid, glycyrrhetinic acid, carnosine, Butylated Hydroxytoluene (BHT) and Butylated Hydroxyanisole (BHA), ergothioneine, vanillin or its derivatives, diethylhexyl syrinylidene malonate, melanostatine, sterol esters, idebenone, dehydroacetic acid, Licohalcone A, creatine, creatinine, feverfew extract, yeast extract, beta glucans, alpha glucans, their salts, their derivatives, their precursors, and/or combinations thereof; and a dermatologically acceptable carrier. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the personal care composition of the invention.
Owner:THE PROCTER & GAMBLE COMPANY
Enzymatic synthesis of soluble glucan fiber
ActiveUS20170198324A1Reduce glycemic indexGood for healthCosmetic preparationsOrganic active ingredientsEnzymatic synthesisDigestion
An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
Owner:NUTRITION & BIOSCIENCES USA 4 INC
Enzymatic synthesis of soluble glucan fiber
InactiveUS20170198322A1Lowering indexGood for healthCosmetic preparationsHydroxy compound active ingredientsEnzymatic synthesisAdditive ingredient
An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
Owner:EI DU PONT DE NEMOURS & CO
Process for obtaining an active ingredient with an immediate tensor effect on the skin, active ingredient and compositions
ActiveUS20130150322A1Smoothing of cutaneous microreliefImprove mechanical propertiesBiocideOrganic active ingredientsAdditive ingredientActive ingredient
The invention relates to a method for obtaining an active ingredient having an immediate anti-wrinkle and skin-tensioning effect, by extracting and purifying high molecular weight polysaccharides from oat bran, fibers and/or grains, and solubilizing and stabilizing the polysaccharides in water. The invention also relates to the product thus obtained, to uses thereof, and to cosmetic compositions containing this active ingredient. The oat bran polysaccharides include alpha-glucans having a molecular weight of between 25 kDa and 300 kDa.
Owner:SOC IND LIMOUSINE DAPPL BIOLOGIQUE SILAB
Enzymatic synthesis of soluble glucan fiber
InactiveUS20170204442A1Good for healthDecreasing glycemic indexMilk preparationOrganic active ingredientsEnzymatic synthesisAdditive ingredient
An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
Owner:EI DU PONT DE NEMOURS & CO
Enzymatic synthesis of soluble glucan fiber
ActiveUS10351633B2Reduce glycemic indexGood for healthOrganic active ingredientsMilk preparationEnzymatic synthesisDigestion
An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
Owner:NUTRITION & BIOSCIENCES USA 4 INC
Kit for quantitatively detecting alpha-glucan by monoclonal antibody immunonephelometry
InactiveCN103698520ASimple and fast operationGood repeatabilityMaterial analysis by observing effect on chemical indicatorImmune complex depositionFreeze-drying
The invention discloses a kit for quantitatively detecting alpha-glucan by monoclonal antibody immunonephelometry. The kit comprises alpha-glucan antibody freeze-drying powder, an antibody diluent, a sample diluent and a standard substance, wherein the alpha-glucan antibody freeze-drying powder is freeze-drying powder of IgM type monoclonal antibody purified in mouse ascites where a hybridoma cell strain D9 with a preservation number of CCTCCC2010107 (China Center for Type Culture Collection C2010107) is injected. The quantitative detection kit provided by the invention has the characteristics of simpliness and convenience in operation, good repeatability, high sensitivity and simple test conditions, is suitable for detection of an alpha-glucan immune complex separated out from a determination reaction system, and is suitable for sugaring processes of cane juice, raw sugar, white granulated sugar, brown granulated sugar, syrup, molasses and the like.
Owner:GUANGZHOU SUGARCANE IND RES INST +1
Method Of Producing Glycogen
ActiveUS20080131941A1Low production costHigh puritySugar derivativesBacteriaWeight decreasingGlucoside
A method of producing glycogen comprising a step of: allowing a branching enzyme having the ability to synthesize glycogen to act on a substrate in a solution to produce a glycogen, wherein the substrate is an α-glucan being linked mainly with α-1,4-glucosidic bonds and having a degree of polymerization of 4 or more, and the number-average molecular weight of saccharides in the solution before initiation of the reaction is more than 180 but not more than 150,000. (The branching enzyme activity of the branching enzyme)/(the molecular-weight-decreasing activity of the branching enzyme) can be 500 or less. The branching enzyme can be a thermostable branching enzyme.
Owner:EZAKI GLICO CO LTD
Amino sugar-containing glucan, method for producing same, and use thereof
InactiveUS20130302405A1Broad utilityImprove securityBiocidePeptide/protein ingredientsCrystallographyPhosphate
An object of the present invention is to provide a glucosamine-containing glucan, a modified product and a conjugate thereof. The glucosamine-containing glucan of the present invention is a glucosamine-containing glucan wherein the glucan has a plurality of non-reducing ends and at least one glucosamine residue is bound via an α-1,4-bond to each of two or more non-reducing ends of the branched α-1,4-glucan, but no glucosamine residue is present at a position other than the non-reducing ends of the branched α-1,4-glucan, wherein the degree of polymerization of the glucan is 15 or more and 4×105 or less. The glucosamine-containing glucan of the present invention can be provided by allowing an α-glucan phosphorylase to act on an aqueous solution comprising a branched α-1,4-glucan and glucosamine-1-phosphate.
Owner:EZAKI GLICO CO LTD
Method of converting beta-1,4-glucan to alpha-glucan
InactiveUS20070092949A1Valid conversionNon-digestibleSugar derivativesFermentationCellobiose phosphorylaseGreek letter beta
A method for production of an α-glucan from a β-1,4-glucan is provided, comprising: reacting a solution containing β-1,4-glucan, a primer, a source of phosphoric acid, β-1,4-glucan phosphorylase, and α-1,4-glucan phosphorylase to produce an α-glucan. In this method, said β-1,4-glucan may be cellobiose, and said β-1,4-glucan phosphorylase may be cellobiose phosphorylase.
Owner:EZAKI GLICO CO LTD +1
Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses
ActiveUS8324375B2Easy to solveReducing lipidCosmetic preparationsOrganic active ingredientsAcetic acidDietary fiber
The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows:(1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4;(2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates;(3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and(4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
Owner:HAYASHIBARA BIOCHEMICAL LAB INC
Amino sugar-containing glucan, method for producing same and use of same
ActiveCN103298947AChange physical and chemical propertiesActive ingredient retentionOther foreign material introduction processesDrug compositionsAlpha-glucan phosphorylasePhosphoric acid
The purpose of the present invention is to provide a glucosamine-containing glucan, a modified product of the glucosamine-containing glucan and a conjugate of the glucosamine-containing glucan. This glucosamine-containing glucan is a glucosamine-containing glucan wherein at least one glucosamine residue is bound, by an alpha-1,4 bond, to each of two or more non-reducing terminals among a plurality of non-reducing terminals of a branched alpha-1,4 glucan but no glucosamine residue is present at any position other than non-reducing terminals of the branched alpha-1,4 glucan, and the glucan has a polymerization degree from 15 to 4*10<5> (inclusive). This glucosamine-containing glucan can be provided by having alpha-glucan phosphorylase act on an aqueous solution that contains a branched alpha-1,4 glucan and glucosamine-1-phosphate.
Owner:EZAKI GLICO CO LTD
Natural tooth cleaning mousse foam composition and preparation method thereof
InactiveCN106236640AEffective cleaning functionPrevent tooth decayCosmetic preparationsToilet preparationsNatural toothGlycerol
The invention discloses a natural tooth cleaning mousse foam composition, which comprises: acerola cherry fruit powder, a green tea extract, a peony root extract, a panax notoginseng extract, an aloe extract, a peppermint extract, a honeysuckle extract, a rice husk extract, a lemon extract, a clove extract, a lotus extract, a Korean angelica sinensis extract, a zanthoxylum nitidum extract, a natural foaming agent, edible glycerol, erythritol, sodium alpha-glucan, xylitol, fructooligosaccharide, and water. According to the present invention, the product is foam-like, and the active ingredients can be rapidly and uniformly attached to the teeth and penetrate into the spaces between the teeth, such that the cleaning function can be effectively provided, and the functions of tooth decay prevention, tooth whitening, gingiva strengthening, tartar clearing and the like can be comprehensively provided.
Owner:马南行
Plants with modified starch metabolism
InactiveCN101970668AExpand production potentialImprove digestibilityTransferasesPlant peptidesSucroseSaccharum
The specification provides methods of obtaining a genetically modified plant which has increased production potential compared to a control plant, the method comprising the steps of i) obtaining a plurality of plants at least one of which comprises in its genome a heterologous polynucleotide, ii) identifying from the plurality of plants a plant which has increased production potential relative to the control plant and comprises the heterologous polynucleotide, and iii) selecting the genetically modified plant, wherein the polynucleotide comprises a transcriptional control sequence operably linked to a nucleic acid sequence which encodes an agent that modifies endogenous starch phosphorylation and / or starch degradation in the plant. In some embodiments, the plant has increased endogenous glycosylase or increased digestibility compared to a control plant. In some specific embodiments, the endogenous starch phosphorylation and / or starch degradation is modified by modifying expression or activity of one or more enzymes selected from the group consisting of alpha-amylase (EC 3.2.1.1), beta-amylase (EC 3.2.1.2), glucoamylase (EC 3.2.1.3), starch phosphorylase (EC2.4.1.1), glycosylase (EC 3.1.33), sucrase-isomaltase (EC 3.2.10), amylomaltase (EC 2.4.1.25), maltase (EC 3.2.1.20), isoamylase, and a-glucan, water dikinase (GWD, EC 2.7.9.4).
Owner:COMMONWEALTH SCI & IND RES ORG +1
High-efficiency adsorption material for flue gas purification
InactiveCN109364892AImprove adsorption capacityHighly selective adsorptionCombination devicesOther chemical processesPolyvinyl alcoholSorbent
The invention relates to the technical field of environmentally friendly adsorption materials, in particular to a high-efficiency adsorption material for flue gas purification. The adsorption materialis composed of a catalytic adsorption carrier and an absorption layer attached to the surface of the catalytic adsorption carrier. The catalytic adsorption carrier includes activated carbon, siliconnitride, zeolite powder, titanium dioxide, aluminum sulfate, nano zinc oxide, polyvinyl alcohol and water. The absorption layer includes pregelatinized starch, glucan, ethylene urea, diethylenetriamine, histidine, nano silver glue, dicumyl peroxide and deionized water. The titanium dioxide is anatase type titanium dioxide or rutile titanium dioxide. The glucan is dextran type alpha-glucan. The adsorption material has a very good cleaning effect on gas pollutants, organic volatile pollutants and heavy metal pollutants and the like in the flue gas.
Owner:合肥易美特建材有限公司
Pediatric fiber mixture
The present invention relates to a liquid nutritional composition for paediatric patients comprising beta-galacto-oligosaccharides, fructan, non-digestible alpha-glucan and hemicellulose.Owner:NV NUTRICIA
A composition capable of promoting skin microecological balance and its preparation method
ActiveCN103462881BPromote proliferationPromote Microecological BalanceCosmetic preparationsToilet preparationsSide effectReaction temperature
The invention discloses a composition capable of promoting skin micro-ecological balance and a preparation method thereof. The composition is composed of skin prebiotics α-glucan oligosaccharide, fructooligosaccharide, β-glucan, plant extract, yeast Extract and natural antibacterial agent Leuconostococcus / radish root ferment filtrate are the main ingredients. The composition of the invention fundamentally regulates the micro-ecological balance of the skin, maintains the health of the skin, overcomes the defects of traditional cosmetics / skin care products that treat the symptoms but not the root cause and are prone to side effects, and has multiple repairing effects of moisturizing, softness and firmness. Skin problems provide new ideas. The preparation method is simple and easy, and the active ingredients of each functional component are kept to the greatest extent by rationally controlling the reaction steps and mixing temperature.
Owner:SHENZHEN GENE BIOLOGICAL TECH
Method for preparing alpha-glucanase by vitue of chaetomium gracile fermentation under ultrasonic condition
InactiveCN103865906AIncrease enzyme activityIncrease growth rateMicroorganism based processesElectrical/wave energy microorganism treatmentBiotechnologyGlucanase
The invention discloses a method for preparing an alpha-glucanase by virtue of chaetomium gracile fermentation under an ultrasonic condition. The method is characterized in that when the chaetomium gracile is cultured in a culture medium, an ultrasonic action having the frequency of 20-40KHZ and the power of 80-120W is applied by the frequency of 40-80 minutes each time for 40-80 seconds each time. Beyond the expectation of the technicist in the field, the method for preparing the alpha-glucanase by virtue of chaetomium gracile fermentation under the low-frequency and low-power ultrasonic condition increases the growth rate of cells, and meanwhile, the enzyme activity of the glucanase is improved by 215%.
Owner:GUANGXI UNIV
Alpha glucans
The present invention relates to the field of poly- and oligosaccharides and their dietary effects. In particular it relates to a method of producing an alpha-glucan containing (alpha 1-> 3) linked D-glucose units. The invention also provides a branched alpha-glucan comprising alternating (alpha1-> 4) and (alpha1-> 3) glucosidic linkages and having (alpha1-> 3,4) branching points, a food composition, and the use of an alpha-glucanotransferase enzyme for reducing the digestible carbohydrates of a starch containing food material. Further aspects of the invention are a bacteria, an enzyme and anexpression vector.
Owner:SOC DES PROD NESTLE SA
Ocentyl succinic short-chain alpha-glucan flavor capsule and preparation method thereof
The invention discloses an ocentyl succinic short-chain alpha-glucan flavor capsule, which is of a nuclear shell structure. A flavor substance is adopted as a nucleus, and ocentyl succinic short-chainalpha-glucan is adopted as a shell. The polymerization degree of the short-chain alpha-glucan obtained in the mode that pullulanase conducts enzymolysis on waxy maize starch is 17-20, and the prepared short-chain alpha-glucan has better flexibility and higher embedding rate for the flavor substance than those of long-chain starch.Owner:CHINA TOBACCO YUNNAN IND
Highly effective production method for recombinant alpha-glucanase fusion protein and related expression carrier and bacterial strain
InactiveCN101139556BHigh expressionHigh purityFungiMicroorganism based processesBiotechnologyBacterial strain
The invention provides a high efficient production method for a recombined alpha-glucanase fused protein. Gene sequence of coded grease yeast alpha-glucanase is obtained by a Polymerase Chain Reaction (PCR) method, and is constructed in a Pichia yeast secretory expression vector with His Tag, and the Pichia yeast is transformed to obtain high expression bacterial strain, and alpha-glucanase fused protein with His Tag in high purity is obtained by an optimal high density fermentation and purifying process. The alpha-glucanase fused protein has high alpha-glucanase activity. The method has simple process, highly expresses alpha-glucanase fused protein, and the obtained alpha-glucanase fused protein has high purity, good activity and low production cost.
Owner:EAST CHINA UNIV OF SCI & TECH
Polysaccharide fermentation composition capable of resisting cancer, virus and inflammation, promoting osteoblast proliferation and promoting intestinal stem cell proliferation and preparation method
The composition provided by the invention contains polysaccharide vegetables, mushrooms and algae as raw material substances, polysaccharide molecules (beta glucan and alpha glucan) are converted andsegmented into small molecular form saccharides through a special fermentation preparation method, and the composition is a polysaccharide fermentation composition with the molecular weight of about 300 Daltons, has a structure different from that of common polysaccharide molecules, is in an organic form, and can be used for preparing polysaccharide products. After the composition is fermented, redundant glucose structures on branched chains are metabolized by thalli, redundant glucose molecules are removed, the sugar molecules can have affinity, and the polysaccharide fermentation compositionwith the coating material has the effects of resisting cancers, viruses and inflammation, promoting osteoblast proliferation and promoting intestinal stem cell proliferation.
Owner:BIOZYME BIOBTECH CORP
Acetaminophen adducts and methods of use thereof
The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.Owner:BIOVENTURES LLC +1
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