Sarafloxacin hydrochloride clathrate and preparation method thereof

A technology of sarafloxacin hydrochloride and inclusion compound, which is applied in the field of medicine, can solve the problems of no sarafloxacin hydrochloride inclusion compound, etc., and achieve the effect of easy operation and simple preparation method
CN103316003BInactive Publication Date: 2015-04-29SHANDONG LONGHAI BIOLOGICAL TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG LONGHAI BIOLOGICAL TECH
Publication Date
2015-04-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to a medical field, more specifically a sarafloxacin hydrochloride clathrate and a preparation method thereof. The sarafloxacin hydrochloride clathrate is prepared by the following raw materials by weight: 1 part of sarafloxacin hydrochloride, 2-5 parts of CH-beta-CD or HP-beta-CD and 1-5 parts of polymer drug accessory; wherein the polymer drug accessory is one selected from polyvinylpyrrolidone, polyethylene glycol 6000 or hydroxypropyl methyl cellulose. The sarafloxacin hydrochloride clathrate is prepared by the following steps of: weighting sarafloxacin hydrochloride, adding it into a sodium hydroxide solution, adding CH-beta-CD or HP-beta-CD into a sarafloxacin hydrochloride solution, heating, stirring, adding the polymer drug accessory, mechanically grinding, vacuum-filtrating, and then freezing and drying to obtain the product. The sarafloxacin hydrochloride clathrate increases solubility of sarafloxacin hydrochloride, raises drug loading and yield of sarafloxacin hydrochloride, and enhances chemical stability.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to a sarafloxacin hydrochloride inclusion compound and a preparation method thereof. Background technique

[0002] Sarafloxacin hydrochloride is a third-generation fluoroquinolone antibacterial drug specially used for animals. It has a broad antibacterial spectrum and strong antibacterial activity. It has good antibacterial activity against Gram-negative bacteria, Gram-positive bacteria and mycoplasma. Antibacterial effect, especially Escherichia coli, Salmonella, Klebsiella, Proteus, Pasteurella multocida, Campylobacter and other enterobacteria. Sarafloxacin hydrochloride absorbs quickly, metabolizes quickly, has almost no residue, and has no cross-resistance with many antibacterial drugs. It is mainly used for the treatment of digestive system, respiratory system, urinary tract infection and mycoplasma caused by sensitive bacteria. However, because sarafloxacin hydrochloride i...

Claims

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