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Preparation method of anticoagulation polylactic acid hemodialysis membrane

A technology of hemodialysis and polylactic acid, applied in semi-permeable membrane separation, chemical instruments and methods, membrane technology, etc., can solve the problems of cumbersome process and complex reaction conditions, and achieve the effect of mild reaction conditions

Active Publication Date: 2013-09-25
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method improves the hydrophilicity, it involves melt polycondensation, esterification, oxidation and hydroformylation reactions, and the process is cumbersome and the reaction conditions are complicated.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step (1). GMA in situ polymerization

[0027] At 50°C, dissolve 150g of polylactic acid and 70g of polyethylene glycol in 780g of N-methylpyrrolidone to obtain a polylactic acid mixture; then add 1g of glycidyl methacrylate (GMA) monomer to the polylactic acid mixture, 0.001 g of azobisisobutyronitrile was added after 30 min of nitrogen gas, and free radical polymerization was carried out at 60° C. under nitrogen protection for 20 h to obtain a polylactic acid casting solution mixed with PGMA.

[0028] Step (2). Diamine grafting

[0029] After the reaction, the polylactic acid casting solution obtained in step (1) was defoamed and filtered, poured into the reaction kettle, and spun into polylactic acid hollow fiber membranes by dry / wet induced phase inversion method; the polylactic acid hollow fiber membranes were used Soak in deionized water for 24 hours, remove the residual solvent on the membrane, dry, and prepare a polylactic acid hollow fiber membrane module; diss...

Embodiment 2

[0034] Step (1). GMA in situ polymerization

[0035] At 55°C, 200g of polylactic acid and 30g of polyethylene glycol were dissolved in 770g of dimethyl sulfoxide to obtain a polylactic acid mixture; then 2.6g of glycidyl methacrylate (GMA) was added to the polylactic acid mixture 0.003 g of azobisisoheptanonitrile was added after nitrogen gas was passed for 32 minutes, and free radical polymerization was carried out at 62 °C under nitrogen protection for 18 hours to obtain a polylactic acid casting solution mixed with PGMA.

[0036] Step (2). Diamine grafting

[0037] After the reaction, the polylactic acid casting solution obtained in step (1) was defoamed and filtered, poured into the reaction kettle, and spun into polylactic acid hollow fiber membranes by dry / wet induced phase inversion method; the polylactic acid hollow fiber membranes were used Soak in deionized water for 25 hours, remove the residual solvent on the membrane, dry, and prepare a polylactic acid hollow fib...

Embodiment 3

[0042] Step (1). GMA in situ polymerization

[0043] At 60°C, dissolve 150g of polylactic acid and 50g of polyethylene glycol in 800g of dimethylacetamide to obtain a polylactic acid mixture; then add 10g of glycidyl methacrylate (GMA) monomer to the polylactic acid mixture , 0.02 g of dibenzoyl peroxide was added after nitrogen gas was passed for 35 min, and free radical polymerization was carried out at 65° C. under nitrogen protection for 16 h to obtain a polylactic acid casting solution mixed with PGMA.

[0044] Step (2). Diamine grafting

[0045] After the reaction, the polylactic acid casting solution obtained in step (1) was defoamed and filtered, poured into the reaction kettle, and spun into polylactic acid hollow fiber membranes by dry / wet induced phase inversion method; the polylactic acid hollow fiber membranes were used Soak in deionized water for 30 hours, remove the residual solvent on the membrane, and dry to prepare a polylactic acid hollow fiber membrane mod...

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PUM

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Abstract

The invention discloses a preparation method of an anticoagulation polylactic acid hemodialysis membrane. Cellulose acetate membranes and polysulfone membranes are widely used in current clinical application. Poly lactic acid has a good membrane-forming property, but is inclined to hydrophobicity, and blood contacting materials are often required to have good hydrophilicity, can reduce the protein adsorption on material surfaces and reduce platelet aggregation. In the preparation method, firstly a polylactic acid hollow fiber membrane with epoxy groups is prepared by a one-step method, then diamine activation of the polylactic acid hollow fiber membrane is carried out, finally heparin is introduced into the activated polylactic acid hollow fiber membrane to obtain the anticoagulation polylactic acid hemodialysis membrane. In the preparation method, the polylactic acid is used as a dialysis membrane material, and the novel dialysis membrane is prepared through use of the wet / dry solution spinning method; and through in-situ polymerization of monomers having double bonds and the epoxy groups, groups of high reaction activity are introduced into a polylactic acid matrix, and reaction conditions of subsequent diamine grafting process and heparin fixing process are mild, so the method is a simple and convenient modification method.

Description

technical field [0001] The invention relates to the technical field of polymer medical materials and hemodialysis, in particular to a preparation method of an anticoagulant polylactic acid hemodialysis membrane. Background of the invention [0002] There are currently nearly 250,000 dialysis patients in my country, including nearly 210,000 hemodialysis patients, an increase of nearly 60% compared with the data in 2010. With the increase in the number of hemodialysis patients, the demand for dialyzers will increase significantly, and there will be higher requirements for the effect of dialysis. The dialysis membrane is the main part that determines the performance of the dialyzer. At present, cellulose acetate membrane and polysulfone membrane are widely used clinically. Further improving the hemocompatibility of dialysis membranes has always been an important subject, among which the development of new hemocompatible membrane materials is an important direction. Polylactic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D69/02B01D71/78B01D67/00
Inventor 刘富薛立新高爱林
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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