Traditional Chinese medicine composite for treating headache and preparation method of traditional Chinese medicine composite

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition for treating headache, can solve the problems of difficult control of drug quality, increase in raw material cost, increase in production cost, etc., and achieve stable and controllable product quality, fast drug release speed and convenient taking. Effect

Active Publication Date: 2013-10-16
XIAN XINTONG PHARM RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent 201110003329.X discloses a medicine for treating migraine. The medicine has obvious curative effect and can effectively treat migraine. Chuanxiong, Gastrodia elata, Kochia scoparia, Prunella vulgaris, Shichangpu, rose, cocklebur, cassia, lotus pod, Piper longum and Yizhi kernel, 16 kinds of raw materials, not to mention the increase of raw material cost, so many types of raw materials are not easy Control the quality of medicines during production, resulting in increased production costs and / or unstable efficacy

Method used

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  • Traditional Chinese medicine composite for treating headache and preparation method of traditional Chinese medicine composite
  • Traditional Chinese medicine composite for treating headache and preparation method of traditional Chinese medicine composite
  • Traditional Chinese medicine composite for treating headache and preparation method of traditional Chinese medicine composite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Preparation of Tianxiong Toufeng Tablets

[0063] 1. Prescription:

[0064] Chuanxiong 750g Gastrodia elata 600g Yuanhu 600g

[0065] Angelica dahurica 300g White peony root 300g Scorpion 45g

[0066] 2, the preparation of Chinese medicine composition:

[0067] Take the medicinal materials (except scorpion) according to the prescription ratio, and decoct three times when the amount of water added is 4 times, 3 times and 3 times the weight of the medicinal materials, and decoct for 1.5 hours each time, filter, combine the filtrate, and concentrate under reduced pressure to For the liquid extract with a relative density of 1.20 (measured at 60°C), add ethanol to make the alcohol content 70%, let it stand for 24 hours, take the supernatant, recover the ethanol, concentrate under reduced pressure to a relative density of 1.30-1.35 (60°C Measure) the thick paste, dry under reduced pressure, and pulverize, pass 100 mesh sieves, get dry soaking powder. Weigh the...

Embodiment 2

[0080] Embodiment two: the pharmacodynamic experiment of Chinese medicine composition

[0081] 【Test drug】

[0082] Test drug name: the traditional Chinese medicine composition obtained in the manner described in Example 1——Tianxiong Toufeng Tablets (hereinafter referred to as "Chinese medicinal composition" unless otherwise indicated), wherein each gram of Chinese medicinal composition is equivalent to 9.03 crude drugs.

[0083] 【Positive control drug】

[0084] Sumatriptan succinate tablets, Tianjin Huajin Pharmaceutical Co., Ltd., specification: 100mg / tablet, batch number: 2A6914T. Zhengtian Pills, China Resources Sanjiu Pharmaceutical Co., Ltd., specification: 6g / bag, batch number: 1202034H.

[0085] Ibuprofen tablets, Chongqing Kerui Pharmaceutical (Group) Co., Ltd., specification: 0.1 g / tablet, batch number: 582001. Estazolam tablets, Huazhong Pharmaceutical Co., Ltd., specification: 1mg / tablet, batch number: 20120402.

[0086] 【Experimental animals】

[0087] SD rats...

Embodiment 3

[0177] The acute toxicity experiment of embodiment three Chinese medicine compositions

[0178] The dry cream powder of traditional Chinese medicine composition is based on the maximum dosage of 4.25g crude drug / ml, 40ml / kg / time and 3 times / 24h (510.00g crude drug / kg / 24h), which is approximately equivalent to 983 times the clinical daily dose. Administer KM mice, and observe the symptoms of toxic reactions and recovery time in mice within 14 days after administration.

[0179] Results: After administration, no abnormalities were found in the motor function, reflex, eye examination indications, cardiovascular indications, saliva secretion, muscle tone, and skin of the mice in the administration group and the control group. The feces of the mice in the two groups showed Wet and granular, no toxic reactions such as convulsions, convulsions, piloerection, analgesia or death. During the experimental observation period, the average body weight growth rate and food intake of the mic...

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composite for treating a headache and a preparation method of the traditional Chinese medicine composite. The traditional Chinese medicine composite is prepared by ligusticum wallichii, rhizoma gastrodiae, angelica dahurica, radix paeoniae alba, rhizoma corydalis and scorpion. According to the traditional Chinese medicine composite and the preparation method, the traditional Chinese medicine composite is centralized in effective part, small in dosage and convenient to take, and a modern pharmacology research verifies that the traditional Chinese medicine composite is precise in curative effect, safe, reliable, fewer in adverse effect, and used for treating the headache. The traditional Chinese medicine composite has effects of promoting blood circulation, dispelling wind, dredging collaterals and alleviating a pain, and can be used for prevention and treatment of various headaches such as migraine and a tension headache.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, in particular, the invention relates to a traditional Chinese medicine composition, preparation, preparation method and application thereof for treating headache. Background technique [0002] Headache is a clinically common frequently-occurring disease with a high incidence rate. Frequent headaches can cause vision loss, fatigue, fever, loss of appetite, weight loss, insomnia, irritability, memory loss, abnormal behavior and other symptoms. According to the epidemiological survey data of primary headache in China, among the population aged 18-65, the incidence rate of primary headache is 23.8%, among which the two most common headaches are 10.77% for tension headache and 9.3% for migraine , the per capita treatment cost for migraine patients is 728 yuan / year. It is worth noting that migraine increases the risk of complications, can increase the risk of ischemic stroke by 2....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61P25/00A61P25/06A61P29/02A61P25/20A61P9/10A61K35/64A61K35/646
Inventor 张登科孙文军
Owner XIAN XINTONG PHARM RES CO LTD
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