Dextran-MLDH-fluorouracil super-molecular skeleton magnetic liposome

A magnetic liposome, fluorouracil technology, applied in the directions of liposome delivery, medical preparations with inactive ingredients, anti-tumor drugs, etc. Spatial distribution and other issues, to achieve significant magnetic targeting specificity, stable plasma concentration effect
CN103356483BActive Publication Date: 2015-06-03NINGXIA MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NINGXIA MEDICAL UNIV
Publication Date
2015-06-03

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Abstract

The invention relates to a processing technology for dextran-MLDH-fluorouracil super-molecular skeleton magnetic liposome. The magnetic liposome takes dextran-MLDH-fluorouracil DMF three-grade super-molecular as the core skeleton, soya lecithin and cholesterol as the lipid raw materials, and is prepared by the reverse evaporating method. The DMF magnetic liposome has a typical in-vitro control release ability, a sensitive magnetic responding ability, an excellent cancer cell proliferation inhibiting ability and a special and durable in-vitro drug process. DMF magnetic liposome is prepared through combination of convention liposome technology and DMF, a novel inorganic nano drug delivery system, and a new approach is provided for magnetic target chemotherapy of fluorouracil, a wide-spectrum anti-cancer drug. The dextran-MLDH-fluorouracil super-molecular skeleton magnetic liposome is suitable for the preparation of magnetic drug liposome, which takes magnetic layered composite hydroxide MLDH as the carrier, has the processing advantages of low cost and simple preparation, and has the characteristics of integration of magnetic-target and control-release functions, durable effect, stable curative effect, and little toxic and side effects.
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Description

technical field

[0001] The invention belongs to the field of development of modern drug delivery systems and preparations thereof, and specifically relates to a magnetic liposome DMFL with the "dextran-MLDH-fluorouracil" supramolecular drug delivery system DMF as the core skeleton, which is suitable for anticancer drug magnetically targeted chemotherapy. Processing and production of magnetic liposomes are required. Background technique

[0002] Fluorouracil is a broad-spectrum antineoplastic drug, which is often used in the treatment of gastrointestinal tumors, breast cancer, ovarian cancer and other diseases. Side effects such as bone marrow suppression.

[0003] Liposome is a phospholipid bilayer microcapsule similar in structure to the cell membrane. It has the advantages of slow release, low toxicity, biocompatibility, good drug solubility, etc., and the possibility of targeted transformation and comprehensive processing. Therefore, it has become In recent years, the r...

Claims

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