Hydrogel with micro-flow passage, as well as preparation method and application thereof

A technology of microfluidic channels and hydrogels, which is applied in biochemical equipment and methods, microbial measurement/inspection, medical science, etc., can solve problems such as high cost, cell damage, and complicated preparation methods, and achieve good mechanical strength, High controllability, support adhesion effect
CN103357072AInactive Publication Date: 2013-10-23THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2013-10-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides hydrogel with a micro-flow passage, as well as a preparation method and an application thereof. The hydrogel comprises a hydrogel base layer, and a hydrogel structural layer bonded with the hydrogel base layer. The surface which is bonded with the hydrogel base layer, of the hydrogel structural layer is provided with a groove structure; the groove structure, together with the hydrogel base layer, forms a micro-flow passage for allowing a fluid to flow in; the other surface of the hydrogel structural layer or the hydrogel base layer which deviates from bonding is respectively provided with through holes corresponding to two ports of the micro-flow passage to form a passage inlet and a passage outlet of the micro-flow passage; the hydrogel base layer and the hydrogel structural layer are both prepared from hydrogel containing sodium alginate and fibrous protein; and the hydrogel base layer and the hydrogel structural layer are bonded by protein fibers formed by the fibrous protein. The hydrogel with the micro-flow passage can be applied to a vascular system in a simulated living body or applied to preparation of kits for biological detection.
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Description

technical field

[0001] The invention relates to a hydrogel with a microfluidic channel, a preparation method and application thereof, and belongs to the technical field of tissue engineering. Background technique

[0002] Hydrogels with microchannel structures can play a very important role in the preparation of functional materials, as well as in the simulation and reconstruction of vascularized tissues in vitro. By fabricating suitable microchannel structures in hydrogels, it is possible to simulate the vasculature in organisms (such as blood vessels, lymphatic vessels, renal tubules, and plant ducts). This is also the basis for mimicking tissue function in vivo in vitro. In addition, microchannels in hydrogels can also be used to control the local physical and chemical properties of hydrogels. However, hydrogel is a kind of hydrophilic polymer material, and its unique physical and chemical properties determine that it is extremely difficult to construct the required mic...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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