Method for preparing 5,6,4'-trihydroxy flavone-7-0-D-glucuronic acid

A technology of glucuronic acid and trihydroxyflavone, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of harsh reaction conditions, expensive reaction reagents, cumbersome process operations, etc., and achieve short synthetic routes , the product is easy to purify, and the effect of shortening the reaction route
CN103374049AActive Publication Date: 2013-10-30KPC PHARM INC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
KPC PHARM INC
Publication Date
2013-10-30

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Abstract

The invention relates to the field of drug synthesis and discloses a method for preparing 5,6,4'-trihydroxy flavone-7-0-D-glucuronic acid. The method is characterized by taking 5,6,7,4'-tetrahydroxy flavone as a raw material, adopting a brand-new synthetic route and carrying out three-step reactions including acylation reaction, glycosylation reaction and acid neutralization reaction after alkaline hydrolysis reaction, thus preparing high-purity 5,6,4'-trihydroxy flavone-7-0-D-glucuronic acid. The preparation method has the advantages of short synthetic route, low cost, high reaction yield and easiness in product purification, and is suitable for industrial production of 5,6,4'-trihydroxy flavone-7-0-D-glucuronic acid.
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Description

technical field

[0001] The invention belongs to the field of drug synthesis, in particular to a method for preparing 5,6,4'-trihydroxyflavone-7-0-D-glucuronic acid. Background technique

[0002] 5,6,4'-trihydroxyflavone-7-0-D-glucuronic acid, also known as scutellarin and scutellarin, is the whole plant of Erigeron breviscapus (Erigeron breviscapus) in the family Asteraceae. The main active ingredient of the flavonoid mixture extracted from Erigeron breviscapus, the molecular formula is C 21 h 18 o 12 , molecular weight is 462.37, and its structural formula is as shown in formula I:

[0003]

[0004] Clinical studies have shown that 5,6,4'-trihydroxyflavone-7-0-D-glucuronic acid has a significant effect on hypertension, cerebral hemorrhage, cerebral thrombosis, cerebral embolism multiple neuritis, chronic arachnoiditis and its sequelae Good curative effect, and also has certain curative effect on rheumatism, coronary heart disease. In addition, a large number of stud...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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