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Cataplasm used for treating skin scars, and preparation method thereof

A cataplasm and scar technology, applied in the field of transdermal drug delivery system, can solve the problems of low oil content, low adhesion of cataplasm, slow drug release speed, etc.

Active Publication Date: 2013-11-27
上海美宝生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There have been many literature reports on the technology of preparing cataplasms by inclusion of volatile oil with β-cyclodextrin, but the oil content contained in them is relatively low
[0006] Chinese invention patent (authorization number CN1754532A) discloses a poultice matrix containing an emulsifier and a preparation method, which uses an emulsifier acrylate / C10-30 alkyl acrylate cross-linked copolymer as an emulsifier, and uses this special The cataplasm base prepared by emulsifier can contain oil-soluble active ingredients or oil-based active ingredients; this method has low drug loading rate, low adhesion of cataplasm, and the emulsifier is a carbomer homologue, so the drug release rate is too slow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve 3g of tartaric acid in 350mL of water, add 10g of carbomer and stir to swell, continue to add 10g of polyvinyl alcohol and 1.5g of disodium ethylenediaminetetraacetic acid solution and stir to obtain a mixed solution I; mix 70g of sodium polyacrylate, 5g of polyvinylpyrrolidone, 5g sodium carboxymethylcellulose, 1.5g aluminum glycolate, 5g titanium dioxide, put in 50g glycerin, stir well to get the glycerin phase; dissolve 15g β-cyclodextrin in 100mL boiling water, add 50g sesame oil and 5g cactus The juice mixture was clathrated, then added 20 g Tween and 3.5 g Span mixed liquid dissolved with 1.5 g menthol, stirred evenly, slowly added glycerin phase to the clathrated liquid, and stirred well to obtain the mixed liquid II. Slowly add the mixed solution II to the mixed solution I, add 100g of glycerin, stir well to obtain a paste, spread it by rolling method, and leave it to cross-link to form a poultice.

Embodiment 2

[0021] Dissolve 5g of tartaric acid in 300mL of water, add 10g of carbomer and stir to swell, continue to add 10g of polyvinyl alcohol and 1.5g of disodium ethylenediaminetetraacetic acid solution and stir to obtain a mixed solution I; mix 80g of sodium polyacrylate, 5g of polyvinylpyrrolidone, 5g sodium carboxymethyl cellulose, 1.5g aluminum glycolate, 0.5g titanium dioxide, put in 40g glycerin, stir well to get the glycerin phase; dissolve 15g β-cyclodextrin in 150mL boiling water, add 100g sesame oil and 5g The cactus juice mixture is clathrated, and then 30 g of Tween and 5 g of Span mixed with 1.5 g of menthol are added, stirred evenly, and the glycerin phase is slowly added to the clathrated liquid, and stirred to obtain a mixed liquid II. Slowly add the mixed solution II to the mixed solution I, add 100g of glycerin, stir well to obtain a paste, spread it by rolling method, and leave it to cross-link to form a poultice.

Embodiment 3

[0023] Dissolve 7g of tartaric acid in 350mL of water, add 10g of carbomer and stir to swell, continue to add 5g of polyvinyl alcohol and 1.5g of disodium ethylenediaminetetraacetic acid solution and stir to obtain a mixture I; 30g of sodium polyacrylate, 5g of polyvinylpyrrolidone, 5g sodium carboxymethylcellulose, 2.5g aluminum glycolate, 0.5g titanium dioxide, put in 50g glycerin, stir well to get the glycerin phase; dissolve 10g β-cyclodextrin in 100mL boiling water, add 200g dropwise under the condition of 50℃ water bath The mixture of sesame oil and 10g of cactus juice is clathrated, then 30g of Tween and 5g of Span mixed with 1.5g of menthol are added, stirred evenly, and the glycerin phase is slowly added to the clathrate, stirred well to obtain the mixed liquid II. Slowly add the mixed solution II to the mixed solution I, add 100g of glycerin, stir well to obtain a paste, spread it by rolling method, and leave it to cross-link to form a poultice.

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PUM

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Abstract

The invention relates to cataplasm used for treating skin scars, and a preparation method thereof. The cataplasm is composed of, by weight: 1-50 parts of sesame oil, 1-10 parts of cactus juice, 0.1-10 parts of carbomer, 0.05-5 parts of tartaric acid, 0.05-10 parts of polyvinyl alcohol, 0.05-10 parts of sodium carboxymethyl cellulose, 0.01-10 parts of disodium ethylenediamine tetraacetate, 0.5-10 parts of sodium polyacrylate, 0.1-10 parts of polyvinyl pyrrolidone, 5-50 parts of glycerin, 0.005-1 part of aluminum glycinate, 0.005-1 part of menthol, 0.05-5 parts of titanium dioxide, 0.1-5 parts of an emulsifier, 0.1-10 parts of beta-cyclodextrin, and 40-70 parts of water. With the cataplasm, defects of low fat-soluble content and low adhesion of traditional cataplasm are overcome, and scars can be treated by using a mixture of sesame oil and cactus juice through a transdermal administration approach.

Description

technical field [0001] The invention relates to a transdermal drug delivery system, in particular to a cataplasm for treating skin scars and a preparation method thereof. Background technique [0002] One of the principles of sesame oil for scar removal is that sesame oil contains more vitamin E, which can maintain the permeability of blood vessels, improve peripheral circulation, maintain epithelial tissue well, promote local blood circulation, and repair scarred skin. At the same time, the unsaturated fatty acids contained in sesame oil can participate in the metabolism of phospholipids and the synthesis of cell membranes, which have protective and anti-aging effects on the skin. Moreover, sesame oil is lubricating and non-volatile, and has a good moisturizing effect, which is beneficial to the regeneration of injured skin and reduces the invasion of germs. [0003] Cactus juice is rich in tyramine, trace elements, vitamins, polysaccharides, plant collagen and other nutri...

Claims

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Application Information

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IPC IPC(8): A61K36/33A61K9/70A61K47/48A61K47/34A61K47/32A61P17/02
Inventor 商庆新魏敏成立萍闫闳
Owner 上海美宝生命科技有限公司
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