Memantine hydrochloride slow-release dry suspension and preparation method thereof

A technology of memantine hydrochloride and dry suspension, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, and devices that make medicines into special physical or ingestible forms, and can solve the problem of unsatisfactory slow-release dry suspension. To solve problems such as drug reporting, to achieve the effects of stabilizing blood drug concentration, solving effectiveness, and simple preparation process

Active Publication Date: 2013-12-04
HAINAN PULIN PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The domestic and foreign patents of memantine hydrochloride retrieved above are mainly patents related to ordinary tablets, sustained-release capsules and sustained-release tablets, and there are no reports related to sustained-release dry suspensions

Method used

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  • Memantine hydrochloride slow-release dry suspension and preparation method thereof
  • Memantine hydrochloride slow-release dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: Preparation of memantine hydrochloride sustained-release dry suspension, using the following prescription:

[0023] Raw and auxiliary materials weight (g)

[0024] Memantine Hydrochloride 28

[0025] Styrene weakly acidic cation exchange resin 90

[0026] Polyacrylic resin RS100 18

[0027] Diethyl phthalate 1.5

[0028] Polyethylene glycol 400 1.5

[0029] Lactose 136

[0030] Sucrose 195

[0031] PVP K30 10

[0032] Xanthan Gum 20

[0033] Propylparaben appropriate

[0034] Purified water

[0035] 500 in total.

[0036] Preparation Process:

[0037] (1) Preparation of memantine hydrochloride-ion exchange resin compound: add the prescription amount of styrene weakly acidic cation exchange resin to a mixer filled with deionized water, add memantine hydrochloride under agitated state and stir evenly, and continue Stir for 3 hours at a rotation speed of 600 rpm, then stand still to precipitate and filter the drug resin, remove the precipitate and place it in a tray, and place it ...

Embodiment 2

[0041] Example 2: Preparation of memantine hydrochloride sustained-release dry suspension, using the following prescription:

[0042] Raw and auxiliary materials weight (g)

[0043] Memantine Hydrochloride 28

[0044] Styrene strong acid cation exchange resin 90

[0045] Polyacrylic resin RS100 12

[0046] Dibutyl sebacate 1.5

[0047] Polyethylene glycol 400 1.5

[0048] Mannitol 136

[0049] Sucrose 201

[0050] PVP K30 10

[0051] Xanthan Gum 20

[0052] Propylparaben appropriate

[0053] Purified water

[0054] 500 in total

[0055] The preparation process and the examples are basically the same.

Embodiment 3

[0056] Example 3: Preparation of memantine hydrochloride sustained-release dry suspension, using the following prescription:

[0057] Raw and auxiliary materials weight (g)

[0058] Memantine Hydrochloride 28

[0059] Styrene strong acid cation exchange resin 90

[0060] Polyacrylic resin RS100 18

[0061] Dibutyl sebacate 1.5

[0062] Polyethylene glycol 400 1.5

[0063] Mannitol 136

[0064] Sucrose 195

[0065] PVP K30 10

[0066] Xanthan Gum 20

[0067] Propylparaben appropriate

[0068] Purified water

[0069] 500 in total

[0070] The preparation process and the examples are basically the same.

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PUM

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Abstract

The invention relates to a memantine hydrochloride slow-release dry suspension and a preparation method thereof. The memantine hydrochloride slow-release dry suspension comprises the following materials, by weight: 5-20% of memantine hydrochloride, 10-40% of ion exchange resin, 0.5-10% of a hydrophilic or water-soluble accessory, 5-20% of a dressing material and 10-50% of other accessories. The preparation technology of the memantine hydrochloride slow-release dry suspension is simple, easy for operation and control, and suitable for industrialized large production. The obtained memantine hydrochloride slow-release dry suspension has stable drug release rate and high accumulation drug release rate; after administration, patients can obtain stable plasma concentration level, so as to effectively reduce administration frequency and toxic and side effects; meanwhile, the memantine hydrochloride slow-release dry suspension solves the problems of medication validity, security and compliance for the elderly.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to memantine hydrochloride sustained-release dry suspension for treating Alzheimer's disease and a preparation method thereof. Background technique [0002] Alzheimer's disease is one of the common diseases of the elderly, mainly manifested as memory loss and recognition impairment, etc., and is a progressive neurodegenerative disorder. Alzheimer's disease can be divided into Alzheimer's disease (AD), vascular dementia and mixed dementia. AD is the main type of Alzheimer's disease. With the aging of the world's population and the improvement of people's living standards, the average life expectancy is also extended. In 2002, the elderly over the age of 60 accounted for 20% of the world's total population. By 2050, the number of elderly people It is expected to reach 21% of the world's total population. With the aging of the world's population, senile dementia has become the primary p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/13A61K47/38A61J3/00
Inventor 范敏华王美红刘华
Owner HAINAN PULIN PHARMA
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