External medicine composition for treating rheumatoid arthritis, preparation method and application of external medicine composition

Abstract

The invention provides an external medicine composition for treating rheumatoid arthritis, which is an external preparation prepared by the following active ingredients in parts by weight: 15-25 parts of gentiana macrophylla, 15-25 parts of caulis sinomenii, 15-25 parts of radix paeoniae alba, 15-25 parts of Chinese angelica and 10-20 parts of tripterygium wilfordii. The invention further provides a preparation method and an application of the external medicine composition. The external medicine composition is used for treating the rheumatoid arthritis, is obvious and controllable in efficacy, and simple and convenient to use, and provides a new clinical administration choice.

Description

technical field [0001] The invention relates to an external pharmaceutical composition for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is an autoimmune disease, which is characterized by joint synovial inflammation and chronic inflammation accompanied by multi-system involvement. Onset, symmetrical distribution. The pathogenesis is not completely clear yet, infection and autoimmune response are the important factors of pathogenesis and disease migration, endocrine, genetic and environmental factors increase its susceptibility. The incidence of RA in the world is 0.3% to 1%, and in China it is 0.32% to 0.36%, and it can occur in all age groups. The main manifestations are multi-joint chronic non-specific inflammation around the symmetry, joint redness, swelling, heat pain and dysfunction in the early stage of the disease, and varying degrees of joint stiffness and deformity in the late stage, accompanied by bo...

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Problems solved by technology

[0003] In recent years, the number of RA patients in my country has exceeded 4 million. The drugs commonly used in clinical practice include non-steroidal anti-inflammatory drugs, slow-acting drugs, and glucocorticoids, etc., but their therapeutic effects are not good.

Non-steroidal anti-inflammatory drugs (NSAIDs) have always been the main category of drugs used in the treatment of RA. Indomethacin, aspirin, diclofenac, ibuprofen, etc. are commonly used clinically. These preparations mainly inhibit the activity of cyclooxygenase (COX). It can reduce the release of prostaglandin, thromboxane and other inflammatory mediators produced by the metabolism of arachidonic acid, thereby improving inflammatory symptoms, and has a certain effect on pain relief, but it cannot change the pathological process of RA, and has certain gastrointestinal effects. tract reaction; slow-acting antirheumatic drugs are considered to have the possibility of controlling the progression of the disease, acting on different immune components in the course of RA, commonly used drugs include methotrexate, cyclosporine, penicillamine and gold preparations, etc. Drugs often act on immune cells, which can improve the symptoms of RA and prevent joint damage, but their application is limited due to their high price; glucocorticoids can quickly and significantly improve the symptoms of rheumatoid arthritis, However, there is often a rebound phenomenon after drug withdrawal, and adverse reactions such as osteoporosis, high blood pressure, and obesity will occur with the prolongation of the course of treatment.

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