External medicine composition for treating rheumatoid arthritis, preparation method and application of external medicine composition

A topical drug, rheumatoid technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems such as damage, gastrointestinal reactions, cannot change the pathological process, etc. obvious effect

Inactive Publication Date: 2013-12-11
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In recent years, the number of RA patients in my country has exceeded 4 million. The drugs commonly used in clinical practice include non-steroidal anti-inflammatory drugs, slow-acting drugs, and glucocorticoids, etc., but their therapeutic effects are not good.
Non-steroidal anti-inflammatory drugs (NSAIDs) have always been the main category of drugs used in the treatment of RA. Indomethacin, aspirin, diclofenac, ibuprofen, etc. are commonly used clinically. These preparations mainly inhibit the activity of cyclooxygenase (COX). It can reduce the release of prostaglandin, thromboxane and other inflammatory mediators produced by the metabolism of arachidonic acid, thereby improving inflammatory symptoms, and has a certain effect on pain relief, but it cannot change the pathological p

Method used

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  • External medicine composition for treating rheumatoid arthritis, preparation method and application of external medicine composition
  • External medicine composition for treating rheumatoid arthritis, preparation method and application of external medicine composition
  • External medicine composition for treating rheumatoid arthritis, preparation method and application of external medicine composition

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Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 pharmaceutical crude drug extraction of the present invention

[0035] Raw material prescription: Gentiana 20g, Qingfengteng 20g, Baishao 20g, Angelica 20g, Tripterygium 15g

[0036] The volatile oil of Angelica sinensis was extracted by steam distillation, the medicinal materials were crushed into 10 meshes, 10 times the amount of water was added, soaked for 3 hours, extracted for 8 hours, and the volatile oil and extract were collected separately for later use. Gentiana chinensis, Qingfengteng, and Radix Paeoniae Alba are soaked for 1 hour, heated and refluxed three times with 9 times, 8 times, and 8 times the amount of 50% ethanol, each time for 1 hour. The ethanol is recovered from the extract until it has no alcohol smell, and it is combined with the mother liquor after extraction of the volatile oil and concentrated.

Embodiment 2

[0037] The preparation of embodiment 2 medicament gel ointment of the present invention

[0038] Raw materials: Gentiana 455g, Qingfengteng 455g, Paeoniae Alba 455g, Angelica 455g, Tripterygium wilfordii 340g, sodium polyacrylate 66g, carbomer 25g, aluminum glycinate 1.8g, citric acid 2.8g, glycerin 100g, castor oil 25g, borneol 32g , water 1000g; a total of 100 stickers.

[0039]Preparation method: the above five herbs are crushed through a 10-mesh sieve, add 10 times the amount of water, soak for 3 hours, steam distillation for 8 hours, collect the volatile oil and extract for later use, soak the remaining 4 herbs for 1 hour, and use 9 times the amount respectively , 8 times the amount, and 8 times the amount of 50% ethanol are heated and refluxed three times, each time for 1 hour, the extract is recovered from the ethanol until it has no alcohol smell, and the mother liquor after the extraction of the volatile oil is combined and concentrated to a relative density of 1.25~ ...

Embodiment 3

[0051] Embodiment 3 screening test of pharmaceutical raw material process parameters of the present invention

[0052] 1. Research on the extraction process of volatile oil in Angelica sinensis

[0053] 1.1 Instruments and reagents

[0054] SB500 gram pulverizer (Shanghai Guangsha Industry and Trade Co., Ltd.); volatile oil extractor (Shanghai Instrument Manufacturing Factory); YP202N electronic balance (Shanghai Precision Scientific Instrument Co., Ltd.); water is deionized water.

[0055] 1.2 Methods and Results

[0056] 1.2.1 Extraction of Angelica volatile oil

[0057] Referring to Appendix X D of the 2010 edition of "Chinese Pharmacopoeia" (Part One), take 100g of Angelica sinensis, put it in a round bottom flask, add a few grains of zeolite and several times the amount of water, connect the volatile oil extractor and the condenser tube, soak for a certain period of time, and slowly heat to Boil, and keep boiling slightly for several hours, then stop heating, let it st...

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Abstract

The invention provides an external medicine composition for treating rheumatoid arthritis, which is an external preparation prepared by the following active ingredients in parts by weight: 15-25 parts of gentiana macrophylla, 15-25 parts of caulis sinomenii, 15-25 parts of radix paeoniae alba, 15-25 parts of Chinese angelica and 10-20 parts of tripterygium wilfordii. The invention further provides a preparation method and an application of the external medicine composition. The external medicine composition is used for treating the rheumatoid arthritis, is obvious and controllable in efficacy, and simple and convenient to use, and provides a new clinical administration choice.

Description

technical field [0001] The invention relates to an external pharmaceutical composition for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (Rheumatoid Arthritis, RA) is an autoimmune disease, which is characterized by joint synovial inflammation and chronic inflammation accompanied by multi-system involvement. Onset, symmetrical distribution. The pathogenesis is not completely clear yet, infection and autoimmune response are the important factors of pathogenesis and disease migration, endocrine, genetic and environmental factors increase its susceptibility. The incidence of RA in the world is 0.3% to 1%, and in China it is 0.32% to 0.36%, and it can occur in all age groups. The main manifestations are multi-joint chronic non-specific inflammation around the symmetry, joint redness, swelling, heat pain and dysfunction in the early stage of the disease, and varying degrees of joint stiffness and deformity in the late stage, accompanied by bo...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P19/02A61P29/00
Inventor 杨荣平秦剑严倩茹王云红张小梅励娜胡荣徐月
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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