A kind of preparation method of non-steroidal anti-inflammatory drug tolmetine
A non-steroidal anti-inflammatory drug, tolmetin technology, applied in the preparation of non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory drug tolmetin preparation field, can solve the problem of difficult to obtain raw materials, difficult to obtain, total revenue Low efficiency and other problems, to avoid production and operation environment problems, avoid pollution problems and reduce production costs
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[0025] 1) Synthesis of (1-methyl-1H-pyrrol-2-yl)-oxo-acetate sodium (III): In a 2000ml flask, add 600g of toluene, 100g of N-methylpyrrole and 160g of triethylamine, After stirring and mixing for 30 minutes, start to slowly add 190g monoethyl oxalyl chloride dropwise, control the temperature 30±3°C during the dropwise addition, and add the dropwise time for 2 hours. and 375g of water, heated to an internal temperature of 70±5°C, stirred and reacted for 2 hours, then cooled to room temperature and allowed to stand for layering to obtain an aqueous layer solution (toluene layer is distilled to recover toluene).
[0026] 2) Synthesis of N-methylpyrrole-2-acetic acid (IV): in the (1-methyl-1H-pyrrol-2-yl)-oxo-acetate sodium (III) aqueous layer solution obtained in step 1) , add 80% hydrazine hydrate 100g and 60g sodium hydroxide solid, heat to 80±3°C and keep it for 2 hours, then slowly heat up to 100°C within 1 hour, and keep it at 100±2°C for 5 hours; cooling reaction solution ...
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