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Orally disintegrating tablet containing meclofenoxate hydrochloride and preparation method thereof

A technology for meclofen axetil hydrochloride and oral disintegrating tablets, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as lack of

Inactive Publication Date: 2014-01-08
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] One of the objectives of the present invention is to provide a meclofenexate hydrochloride orally disintegrating tablet with a good taste and a simple and easy preparation process, so as to solve the problem of lack of meclofenexate hydrochloride preparations suitable for the elderly, children and patients with dysphagia. question

Method used

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  • Orally disintegrating tablet containing meclofenoxate hydrochloride and preparation method thereof
  • Orally disintegrating tablet containing meclofenoxate hydrochloride and preparation method thereof
  • Orally disintegrating tablet containing meclofenoxate hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Each tablet contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0020]

[0021]

[0022] The preparation process is as follows: Meclofenoxate hydrochloride, mannitol, sucralose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and magnesium stearate are respectively passed through an 80-mesh sieve, and the powder is directly compressed into tablets after mixing evenly. Obtain meclofenoxate hydrochloride orally disintegrating tablet.

[0023] Evaluation: The obtained meclofenoxate hydrochloride orally disintegrating tablets were smooth discs with slow disintegration and bitter taste. The method for measuring the disintegration time is as follows: take six 10ml small beakers, add 2ml of water at a constant temperature to 37°C respectively, put 1 tablet of this product in each, place it statically, and record the disintegration time.

Embodiment 2

[0025] Each tablet contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0026]

[0027] The preparation process is as follows: pass mannitol, sucralose, microcrystalline cellulose, low-substituted hydroxypropyl cellulose, and hydroxypropyl methylcellulose E-15 through an 80-mesh sieve, mix well, add water to make binder granulation , dried at 60°C, granulated; then added meclofenoxate hydrochloride and magnesium stearate, mixed evenly, and then pressed into tablets;

[0028] Evaluation: The appearance of the obtained meclofenoxate hydrochloride orally disintegrating tablet is a smooth round tablet, and the disintegration is improved, and the taste is still bitter after 30-40 seconds. The method for measuring the disintegration time is as follows: take six 10ml small beakers, add 2ml of water at a constant temperature to 37°C respectively, put 1 tablet of this product in each, place it statically, and record the disintegration time.

Embodiment 3

[0030] Each tablet contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0031]

[0032]

[0033] The preparation process is as follows: pass mannitol, sucralose, microcrystalline cellulose, sodium carboxymethyl starch, hydroxypropylmethylcellulose E-15, and citric acid through an 80-mesh sieve, mix well, and then add water to make a binder Granulate, dry at 60°C, and granulate; add meclofenoxate hydrochloride and magnesium stearate, mix evenly, and press into tablets to obtain meclofenoxate hydrochloride orally disintegrating tablets.

[0034] Evaluation: The appearance of the obtained meclofenoxate hydrochloride orally disintegrating tablet is a smooth disc, which disintegrates within 30 seconds, and the taste is improved. The method for measuring the disintegration time is as follows: take six 10ml small beakers, add 2ml of water at a constant temperature to 37°C respectively, put 1 tablet of this product in each, place it statically, and record the d...

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Abstract

The invention belongs to the technical field of medicine and relates to an orally disintegrating tablet containing meclofenoxate hydrochloride and a preparation method thereof. The orally disintegrating tablet containing meclofenoxate hydrochloride is used for treating traumatic coma, alcoholism, neonatal anoxia and nocturia enuresis. The orally disintegrating tablet containing meclofenoxate hydrochloride tastes good and the preparation technology is simple and feasible. Compared with products available in the market at present, the orally disintegrating tablet containing meclofenoxate hydrochloride is quite suitable for the old, children and patients with dysphagia.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a meclofenoxate hydrochloride orally disintegrating tablet and a preparation method thereof, which are used for treating traumatic coma, alcoholism, neonatal hypoxia, and children's enuresis. Background technique [0002] Meclofenoxate hydrochloride is a central nervous system stimulant and brain neurotrophic drug, which can improve the function of the central system, including causing awakening, invigorating the spirit, exciting breathing, improving nerve reflexes and increasing free activities. It can promote protein assimilation, in It can be used as a raw material for the synthesis of choline and acetylcholine in the body, and then synthesize lecithin, thereby changing the content of neurotransmitters in the central nervous system, increasing the amount of acetylcholine in the brain, having anti-hypoxia effects, promoting the oxidation-reduction reaction of brain cells...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/216A61K47/38A61K47/36A61K47/34A61P25/20A61P39/06A61P3/00A61K47/32
Inventor 赵伟康静王红霞李化淋
Owner 天津市聚星康华医药科技有限公司
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