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Phthalocyanine-quantum dot novel photosensitizer and preparation method thereof

A technology of quantum dots and photosensitizers, applied in the field of interdisciplinary, to achieve the effect of avoiding cell tissue, strong photostability, and easy operation

Inactive Publication Date: 2015-05-20
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although infrared light can reduce the absorption and scattering effects of biological tissues, the development of photosensitizers that absorb infrared light efficiently, such as two-photon photosensitizers, remains a challenge

Method used

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  • Phthalocyanine-quantum dot novel photosensitizer and preparation method thereof
  • Phthalocyanine-quantum dot novel photosensitizer and preparation method thereof
  • Phthalocyanine-quantum dot novel photosensitizer and preparation method thereof

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preparation example Construction

[0037] The preparation method of the phthalocyanine solution in following embodiment is as follows: Take 2.833g of copper phthalocyanine powder and dissolve it in 25mL of deionized water to obtain the primary color paste of copper phthalocyanine with a concentration of 4.56279×10 -4 mol / L, dilute the phthalocyanine color paste with deionized water to obtain a concentration of phthalocyanine of 4.5×10 -5 mol / L, 7.5×10-5 mol / L, 1.0×10 -4 mol / L and 1.5×10 -4 mol / L.

[0038] The preparation method of the CdTe quantum dot solution in the following examples is as follows: Take solid CdTe9.14×10 -3 mg was dissolved in 10mL deionized water to obtain a CdTe quantum dot solution with a concentration of 3.807×10 -5 mol / L. Take 20uL CdTe quantum dots, use deionized water as the solvent, and dilute the QDs 5 times to obtain a concentration of CdTe quantum dots of 7.61×10 -6 mol / L.

[0039] Depend on image 3 It can be seen that copper phthalocyanine has two absorption peaks, ...

Embodiment 1

[0041] A new photosensitizer of phthalocyanine-quantum dots, which is a system composed of phthalocyanine solution and CdTe quantum dot solution, and the molar concentration of phthalocyanine is 1.5×10 -4 mol / L, the volume is 3mL, the concentration of CdTe quantum dot solution is 7.61×10 -6 mol / L, the volume is 20 uL.

[0042] The preparation method of the above-mentioned phthalocyanine-quantum dot novel photosensitizer comprises the following steps:

[0043] (1) Dissolve phthalocyanine powder in deionized water, the molar concentration of phthalocyanine is 1.5×10 -4 mol / L, make phthalocyanine solution;

[0044] (2) Dissolve solid CdTe in deionized water, and the concentration of CdTe quantum dot solution is 7.61×10 -6 mol / L;

[0045] (3) Thoroughly mix the phthalocyanine solution and the CdTe quantum dot solution at a volume ratio of 150:1, and ultrasonically oscillate for 30 minutes at 27°C to obtain a solution system, which is the new phthalocyanine-quantum dot photos...

Embodiment 2

[0047] A new photosensitizer of phthalocyanine-quantum dots, which is a system composed of phthalocyanine solution and CdTe quantum dot solution, and the molar concentration of phthalocyanine is 1.0×10 -4 mol / L, the volume is 3mL, the concentration of CdTe quantum dot solution is 7.61×10 -6 mol / L, the volume is 20 uL.

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Abstract

The invention discloses a novel phthalocyanine-quantum dot photosensitizer, which is a system composed of phthalocyanine solution and CdTe quantum dot solution. The photosensitizer of the present invention has the property of fluorescence resonance energy transfer under the condition of two-photon excitation, and finds out the optimal ratio concentration and optimal excitation power to obtain the best efficiency of fluorescence resonance energy transfer. The invention has certain practical significance in the field of life sciences, especially in the application of two-photon photodynamic therapy.

Description

technical field [0001] The invention relates to interdisciplinary fields such as chemistry, physics and material science, and more specifically relates to a novel phthalocyanine-quantum dot photosensitizer and a preparation method thereof. Background technique [0002] With the development of modern science and technology, the demand for functional dyes in the high-tech field is increasing. The application of phthalocyanine and its compounds is not limited to pigments, inks and catalysts. Phthalocyanine compounds have unique properties Due to special properties such as photochemistry, photophysics, and nonlinear optics, "functional dyes" have been developed rapidly. There are many types of phthalocyanine and its compounds, such as zinc phthalocyanine, iron phthalocyanine, magnesium phthalocyanine, copper phthalocyanine and so on. Phthalocyanine dyes have also been widely used in cell labeling, but their fluorescence lifetime is short and they are prone to photobleaching. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
Inventor 李芳何志聪
Owner WUHAN INSTITUTE OF TECHNOLOGY